Primary prevention of lifestyle-related diseases based on the food-entrainable circadian pacemaker

• Project/Area Number: 16K00912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Fukushima Medical University
• Principal Investigator: Ohtsuru Akira 福島県立医科大学, 医学部, 教授 (00233198)
• Co-Investigator(Kenkyū-buntansha): 緑川 早苗 福島県立医科大学, 医学部, 准教授 (10325962)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 生活習慣病 / 一次予防 / メタボリック症候群 / 食事時間 / 睡眠 / 体内時計 / 肥満 / 概日リズム / グレリン / レプチン

Outline of Final Research Achievements

Like lifestyle parameters such as obesity, evacuation was shown in a significant risk factor of developing metabolic syndrome, diabetes, hypertension in the survey of lifestyle-related diseases in disaster-affected areas. Focusing on the primary prevention strategy, it was found that eating three times a day without skipping breakfast and exercise significantly contributed to the improvement of liver dysfunction. On the other hand, no relation was observed between factors such as snacks eating habit, midnight meals, meal speed, alcohol consumption, sleep and general mental health status. It was also shown that traumatic stress is associated with the onset of metabolic syndrome. In addition, some research plan could not be carried out.

Academic Significance and Societal Importance of the Research Achievements

震災後1－2年以内にメタボリック症候群や糖尿病、その他の生活習慣病を、新規に発症するケースは、避難生活を送る人が、そうでない人と比べて1.4倍～2倍程度多かった。特に避難の影響は急な生活習慣病の発症に関連していた。一次予防において運動や睡眠などによる改善の寄与が不十分であり、より複合的な要因が疑われた。トラウマスコアとの関連がある病態もあることより、発症の多様性に交感神経系が関連してる可能性が示唆された。ゆっくりと発症してくる一般的な生活習慣病と、災害後の生活習慣病発症様式の違いに着目した一次予防の戦略の重要性が示唆された。

Research Products

• [Journal Article] Effects of Psychological and Lifestyle Factors on Metabolic Syndrome Following the Fukushima Daiichi Nuclear Power Plant Accident (2020)
  • Author(s): Takahashi A, Ohira T, Okazaki K, Yasumura S, Sakai A, Maeda M, Yabe H, Hosoya M, Ohtsuru A, Kawasaki Y, Shimabukuro M, Kazama J, Hashimoto S, Watanabe K, Nakano H, Hayashi F, Ohto H, Kamiya K, Ohira H.
  • Journal Title: J Atheroscler Thromb Volume: - Issue: 9 Pages: 1010-1018
  • DOI: 10.5551/jat.52225
  • NAID: 130007894650
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Association Between Self-Reported Sleep Dissatisfaction After the Great East Japan Earthquake, and a Deteriorated Socioeconomic Status in the Evacuation Area (2020)
  • Author(s): Zhang W, Ohira T, Maeda M, Nakano H, Iwasa H, Yasumura S, Ohtsuru A, Harigane M, Suzuki Y, Horikoshi N, Takase K, Takahashi A, Yabe H, Kamiya K
  • Journal Title: Sleep Med Volume: 68 Pages: 63-70
  • DOI: 10.1016/j.sleep.2019.09.004
  • Peer Reviewed
• [Journal Article] Influence of Post-Disaster Evacuation on Childhood Obesity and Hyperlipidemia (2020)
  • Author(s): Kawasaki Y, Nakano H, Hosoya M, Yasumura S, Ohira T, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Takahashi A, Kobashi G, Kamiya K.
  • Journal Title: Pediatr Int Volume: - Issue: 6 Pages: 669-676
  • DOI: 10.1111/ped.14162
  • NAID: 120007118663
  • Peer Reviewed
• [Journal Article] Effects of lifestyle on hepatobiliary enzyme abnormalities following the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey. (2018)
  • Author(s): Takahashi A, Ohira T, Okazaki K, Yasumura S, Sakai A, Maeda M, Yabe H, Hosoya M, Ohtsuru A, Kawasaki Y, Suzuki H, Shimabukuro M, Sugiura Y, Shishido H, Hayashi Y, Nakano H, Kobashi G, Kamiya K, Ohira H.
  • Journal Title: Medicine (Baltimore) Volume: 97 Issue: 42 Pages: e12890-e12890
  • DOI: 10.1097/md.0000000000012890
  • Peer Reviewed / Open Access
• [Journal Article] Associations of disaster-related and psychosocial factors with changes in smoking status after a disaster: a cross-sectional survey after the Great East Japan Earthquake. (2018)
  • Author(s): Nakano H, Ohira T, Maeda M, Yabe H, Ohtsuru A, Suzuki Y, Harigane M, Horikoshi N, Nagai M, Zhang W, Takahashi H, Yasumura S, Iso H, Kamiya K
  • Journal Title: BMJ Open Volume: 8 Issue: 6 Pages: e018943-e018943
  • DOI: 10.1136/bmjopen-2017-018943
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey (2017)
  • Author(s): Takahashi A, Ohira T, Uemura M, Hosoya M, Yasumura S, Hashimoto, Ohira H, Sakai A, Ohtsuru A, Satoh H, Kawasaki Y, Suzuki H, Sugiura Y, Shishido H, Hayashi Y, Takahashi H, Nakano H, Kobashi G, Ozasa K, Ohto H, Abe M.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 776-776
  • DOI: 10.1038/s41598-017-00776-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evacuation is a risk factor for diabetes development among evacuees of the Great East Japan earthquake: A 4-year follow-up of the Fukushima Health Management Survey (2017)
  • Author(s): Satoh H, Ohira T, Nagai M, Hosoya M, Sakai A, Yasumura S, Ohtsuru A, Kawasaki Y, Suzuki H, Takahashi A, Sugiura Y, Shishido H, Hayashi Y, Takahashi H, Kobashi G, Ozasa K, Hashimoto S, Ohto H, Abe M, Kamiya K.
  • Journal Title: Diabetes & Metabolism Volume: 17 Issue: 3 Pages: 30517-30517
  • DOI: 10.1016/j.diabet.2017.09.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of socioeconomic factors on cardiovascular-related symptoms among residents in Fukushima after the Great East Japan Earthquake: a cross-sectional study using data from the Fukushima Health Management Survey (2017)
  • Author(s): Zhang W, Ohira T, Yasumura S, Maeda M, Otsuru A, Harigane M, Horikoshi N, Suzuki Y, Yabe H, Nagai M, Nakano H, Hirosaki M, Uemura M, Takahashi H, Kamiya K, Yamashita S, Abe M.
  • Journal Title: BMJ Open Volume: 7 Issue: 6 Pages: e014077-e014077
  • DOI: 10.1136/bmjopen-2016-014077
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The impact of evacuation on the incidence of chronic kidney disease after the Great East Japan Earthquake: The Fukushima Health Management Survey. (2017)
  • Author(s): Hayashi Y, Nagai M, Ohira T, Satoh H, Sakai A, Ohtsuru A, Hosoya M, Kawasaki Y, Suzuki H, Takahashi A, Sugiura Y, Shishido H, Takahashi H, Yasumura S, Kazama JJ, Hashimoto S, Kobashi G, Ozasa K, Abe M.
  • Journal Title: Clin Exp Nephrol Volume: 印刷中 Issue: 6 Pages: 995-1002
  • DOI: 10.1007/s10157-017-1395-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome (2017)
  • Author(s): Hashimoto S, Nagai M, Fukuma S, Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Kamiya K, Yamashita S, Fukuhara SI, Ohto H, Abe M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 3 Pages: 327-337
  • DOI: 10.5551/jat.35824
  • NAID: 130005397946
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evacuation after the Great East Japan Earthquake was associated with poor dietary intake: The Fukushima Health Management Survey (2017)
  • Author(s): Zhang W, Ohira T, Abe M, Kamiya K, Yamashita S, Yasumura S, Ohtsuru A, Masaharu M, Harigane M, Horikoshi N, Suzuki Y, Yabe H, Yuuki M, Nagai M, Takahashi H, Nakano H
  • Journal Title: Journal of Epidemiology Volume: 27 Issue: 1 Pages: 14-23
  • DOI: 10.1016/j.je.2016.08.002
  • NAID: 130005316510
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Presentation] Difficulties of communication for survey and decision aids in the responses after nuclear disaster (2018)
  • Author(s): Ohtsuru A, Midorikawa S, Ohba T, Miyazaki M.
  • Organizer: Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster The 7th International Symposium
  • Int'l Joint Research / Invited