Effect of lactic acid bacteria intake on the helth of dam and infant during pregnancy and lactation

• Project/Area Number: 16K00919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Seitoku University
• Principal Investigator: Komatsuzaki Noriko 聖徳大学, 人間栄養学部, 准教授 (20536312)
• Co-Investigator(Kenkyū-buntansha): 藤原 しのぶ 聖徳大学, 人間栄養学部, 准教授 (10279672) ; 佐藤 明恵 聖徳大学, 人間栄養学部, 助手 (20774003)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 乳酸菌 / プロバイオティクス / 妊娠・授乳期 / コレステロール低下作用 / 人工胃液耐性 / 胆汁酸耐性 / 低カルシウム食 / カルシウム代謝 / 高脂肪食 / 腸内細菌叢 / 肥満 / カルシウム不足

Outline of Final Research Achievements

We examined the effects of Lactobacillus paracasei during pregnancy and lactation on in mice fed a high-fat diet. Lb. paracasei reduces the content of liver lipids in pups of high-fat diets. It is thought that ingesting Lb. paracasei affects the formation of bacterial flora in dams.
The probiotic of Lb. paracasei was examined. Lactobacillus casei was used as a control. Lb. paracasei showed high tolerance for the gastric juice although the tolerance for bile acid was low. Cholesterol and bile acid binding abilities of Lb. paracasei was higher than L. casei. Therefore, it was suggested that Lb. paracasei may be effectively applied as probiotics Lactobaillus.

Academic Significance and Societal Importance of the Research Achievements

Lactobacillus paracasei NFRI 7415は、生きたまま腸に到達し、腸内細菌叢の改善に役立つと同時に、乳酸菌のコレステロール低下作用が脂質代謝や腸管免疫に影響を与えていることが示唆された。本研究の成果は、妊娠・授乳期の母親と乳児の生活習慣病予防と健康増進に寄与する新規なプロバイオティクス効果を有する食品素材となり得ると考える。

Research Products

• [Presentation] Effect of lactic acid bacteria intake on the health of dam and infant mice (2018)
  • Author(s): Abe A, Fujihara S, Komatsuzaki N
  • Organizer: 12th International Conference on Childhood Obesity and Nutrition
  • Int'l Joint Research
• [Presentation] Effect of lactic acid bacteria during pregnancy and lactation in mice fed a high-fat diet. (2017)
  • Author(s): Akie Sato, Mizuho Endo, Shinobu Fujihara, Noriko Komatsuzaki
  • Organizer: 10th EFAD(European Federation of the Associations of Dietitians) conference
  • Int'l Joint Research