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Search and application of novel functional food and its components that prevent thrombosis caused by modern lifestyle

Research Project

Project/Area Number 16K00920
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionTeikyo University

Principal Investigator

Naoki Ohkura  帝京大学, 薬学部, 准教授 (60349256)

Co-Investigator(Kenkyū-buntansha) 谷口 雅彦  大阪薬科大学, 薬学部, 教授 (00278590)
忍足 鉄太  帝京大学, 薬学部, 教授 (00279043)
大石 勝隆  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 (50338688)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords食品機能 / 血栓症 / 生活習慣 / 健康食品 / 保健機能食品
Outline of Final Research Achievements

In this study, we used a mouse model that is prone to thrombosis due to obesity, aging, and sleep disorders, and found a new food functional component that improves the thrombotic tendency caused by the modern disturbed lifestyle. The aim of this study is to apply these components to prevent thrombosis. By using various model mice, it was found that intake of ashitaba and kurozu may improve the thrombotic tendency. Our study showed that ashitaba and kurozu may be applicable to the prevention of thrombosis from the diet.

Academic Significance and Societal Importance of the Research Achievements

本研究により、現代の生活習慣が引き起こす血栓症を食生活から予防できる食品やその食品成分の候補を見出すことができた。これらの食品を食生活に取り入れたり、食品成分を利用して新たな保健機能食品を開発すれば、血栓症の予防という面から国民の健康な生活の維持に貢献できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016

All Journal Article (17 results) (of which Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Ashitaba (Angelica keiskei) Exerts Possible Beneficial Effects on Metabolic Syndrome.2019

    • Author(s)
      Ohkura N, Atsumi G, Uehara S, Ohkta M, Taniguchi M.
    • Journal Title

      OBM Integrative and Complementary Medicine

      Volume: 4(1) Issue: 1 Pages: 1-1

    • DOI

      10.21926/obm.icm.1901005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible antithrombotic effects of Angelica keiskei (Ashitaba).2018

    • Author(s)
      Ohkura N, Atsumi G, Ohnishi K, Baba K, Taniguchi M.
    • Journal Title

      Die Pharmazie

      Volume: 73(6) Pages: 315-317

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice2018

    • Author(s)
      Ohta M, Fujinami A, Oishi K, Kobayashi N, Ohnishi K, Ohkura N.
    • Journal Title

      Journal of Dietary Supplements

      Volume: 16 Issue: 3 Pages: 331

    • DOI

      10.1080/19390211.2018.1458366

    • URL

      https://localhost/en/publications/c474480d-df85-4aa2-853e-6028dae5d4e3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of fermented rice vinegar Kurozu and its sediment on inflammation-induced plasminogen activator inhibitor 1 (PAI-1) increase2018

    • Author(s)
      Naoki Ohkura, Fumiko Kihara-Negishi, Akira Fujii, Hiroaki Kanouchi, Katsutaka Oishi, Gen-ichi Atsumi, Masanobu Nagano
    • Journal Title

      Food and Nutrition Sciences

      Volume: 9(3) Issue: 03 Pages: 235-246

    • DOI

      10.4236/fns.2018.93018

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An in vitro screening study of food functions among vegetable cultivars consumed in Japan2018

    • Author(s)
      Ohkura N, Fujita R, Kanai R, Ishibashi K, Ueda H, Atsumi G.
    • Journal Title

      Am J Res Med Sci

      Volume: 3(1) Pages: 1-6

    • DOI

      10.5455/ajrms.20180126090406

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positions of Hydroxyl Groups in Chrysin are Critical for Inhibiting Plasminogen Activator Inhibitor-1 Release from Human Umbilical Vein Endothelial Cells2017

    • Author(s)
      Naoki Ohkura, Kumiko Ando, Yuko Takata, Shiho Kanai, Kenichi Ishibashi, Masahiko Taniguch, Tomoki Tatefuji and Gen-ichi Atsumi
    • Journal Title

      Nat Prod Commun.

      Volume: 12(4) Pages: 499-502

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of PPARγ at an Early Stage of Differentiation Enhances Adipocyte Differentiation of MEFs Derived from Type II Diabetic TSOD Mice and Alters Lipid Droplet Morphology2017

    • Author(s)
      Kenichi Ishibashi, Yoshihiro Takeda, Eriko Nakatani, Kana Sugawara, Ryo Imai, Mayu Sekiguchi, Risa Takahama, Naoki Ohkura, Gen-ichi Atsumi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 6 Pages: 852-859

    • DOI

      10.1248/bpb.b17-00030

    • NAID

      130005688069

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 明日葉に抗血栓作用があるのか2017

    • Author(s)
      大藏直樹
    • Journal Title

      フードスタイル21

      Volume: 2017年5月号 Pages: 24-27

    • NAID

      40021207985

    • Related Report
      2017 Research-status Report
  • [Journal Article] Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects2017

    • Author(s)
      Oishi K, Yasumoto Y, Higo-Yamamoto S, Yamamoto S, Ohkura N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 483 Issue: 1 Pages: 165

    • DOI

      10.1016/j.bbrc.2016.12.173

    • URL

      https://pure.teikyo.jp/en/publications/928da7d7-94b1-430a-8534-472716651c45

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cinnamic acid shortens the period of the circadian clock in mice2017

    • Author(s)
      Oishi K, Yamamoto S, Oike H, Ohkura N, Taniguchi M
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 9 Pages: 232-237

    • DOI

      10.1016/j.bbrep.2016.12.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous Determination of Catechins and Caffeine in Green Tea-Based Beverages and Foods for Specified Health Uses2017

    • Author(s)
      Maruyama K, Kihara-Negishi F, Ohkura N, Nakamura Y, Nasui M, Saito M
    • Journal Title

      Food and Nutrition Sciences

      Volume: 8 Issue: 03 Pages: 316-325

    • DOI

      10.4236/fns.2017.83021

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positions of Hydroxyl Groups in Chrysin are Critical for Inhibiting Plasminogen Activator Inhibitor-1 Release from Human Umbilical Vein Endothelial Cells2017

    • Author(s)
      Ohkura N, Ando K, Takata Y, Kanai S,Ishibashi K, Taniguchi M, Tatefuji T, Atsumi G
    • Journal Title

      Natural Product Communications

      Volume: 4 Pages: 499-502

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 止血作用を持つ植物由来物質2017

    • Author(s)
      大藏直樹
    • Journal Title

      THE CHEMICAL TIMES

      Volume: 1 Pages: 22-27

    • Related Report
      2016 Research-status Report
  • [Journal Article] 明日葉に抗血栓作用があるのか2017

    • Author(s)
      大藏直樹
    • Journal Title

      フードスタイル21

      Volume: 21

    • NAID

      40021207985

    • Related Report
      2016 Research-status Report
  • [Journal Article] Effects of a diet containing Brazilian propolis on lipopolysaccharideinduced increases in plasma plasminogen activator inhibitor-1 levels in mice2016

    • Author(s)
      Ohkura N, Oishi K, Kihara-Negishi F, Atsumi GI, Tatefuji T.
    • Journal Title

      J Intercult Ethnopharmacol.

      Volume: 5 Issue: 4 Pages: 439

    • DOI

      10.5455/jice.20160814112735

    • URL

      https://pure.teikyo.jp/en/publications/b6d6b3e7-48ba-47b8-a371-61cfd2bb239a

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-platelet effects of chalcones from Angelica keiskei Koidzumi (Ashitaba) in vivo2016

    • Author(s)
      Ohkura N, Ohnishi K, Taniguchi M, Nakayama A, Usuba Y, Fujita M, Fujii A, Ishibashi K, Baba K, Atsumi G.
    • Journal Title

      Die Pharmazie

      Volume: 71 Pages: 651-654

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice2016

    • Author(s)
      Oishi K, Ohkura N, Yasumoto Y, Yamamoto S.
    • Journal Title

      Chronobiol Int.

      Volume: 34 Issue: 2 Pages: 254

    • DOI

      10.1080/07420528.2016.1256299

    • URL

      https://pure.teikyo.jp/en/publications/c89aa125-9726-4f98-b53e-cc19b7457a94

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 明日葉黄汁粉末摂取による肥満マウスの皮下脂肪層に対する組織学的検討2018

    • Author(s)
      赤瀬智子、伊藤瑞季、大藏直樹、槇原弘子、福田真佑、矢野道子、伊吹愛
    • Organizer
      第25回日本未病システム学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血液凝固を阻害するポリフェノールの探索2018

    • Author(s)
      大藏直樹、金子広実、厚味厳一、谷口雅彦
    • Organizer
      日本生薬学会第65年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 黒酢もろみ末エタノール抽出物および分画物の食品機能の評価2018

    • Author(s)
      大藏直樹、植木翔吾、原実之莉、西村魁人、石橋賢一、叶内宏明、藤井暁、長野正信、谷口雅彦、厚味厳一
    • Organizer
      第23回日本フードファクター学会、第12回日本ポリフェノール学会、第15回日本カテキン学会 合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 黒酢もろみ末エタノール抽出物に含まれる機能性物質の探索2018

    • Author(s)
      西村魁人、植木翔吾、藤井暁、長野正信、叶内宏明、厚味厳一、大藏直樹
    • Organizer
      第5回時間栄養科学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 黒酢もろみ末エタノール抽出物に含まれる機能性物質の探索2018

    • Author(s)
      西村魁人、植木翔吾、原実之莉、石橋賢一、藤井暁、長野正信、谷口雅彦、大藏直樹、厚味厳一
    • Organizer
      第19回 Pharmaco-hematologyシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 機能性食品の開発へのTSOD マウス応用の検討2018

    • Author(s)
      大藏直樹
    • Organizer
      第12 回TSOD(肥満・糖尿病)マウス研究会情報交換会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロファージ共培養下での脂肪細胞由来マイクロパーティクルの血液凝固亢進2018

    • Author(s)
      外川弘大、武田剛寛、中谷絵理子、石橋賢一、大藏直樹、板部洋之、厚味厳一
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 黒酢および黒酢もろみ末による血栓症予防の可能性についての基礎的検討2017

    • Author(s)
      大藏直樹、藤井暁、叶内宏明、根岸文子、大石勝隆、厚味厳一、長野正信
    • Organizer
      第39回日本血栓止血学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 黒酢および黒酢もろみによる血栓症予防の可能性の検討2017

    • Author(s)
      大藏直樹
    • Organizer
      第4回日本黒酢研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] アシタバ黄汁を長期摂取させて飼育した高齢マウスを用いた検討2016

    • Author(s)
      大藏直樹、大西克典、大石勝隆、厚味厳一、馬場きみ江、谷口雅彦
    • Organizer
      日本生薬学会第63年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] LPSおよび高脂肪食摂取による負荷が睡眠障害マウスの血液凝固線溶系に与える影響2016

    • Author(s)
      大藏直樹、肥後(山本)明花、大石勝隆
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 明日葉カルコンのマウスモデルにおけるPAI-1上昇抑制効果2016

    • Author(s)
      大藏直樹、厚味厳一、大石勝隆、藤波 綾、谷口雅彦、太田光熙、大西克典
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 黒酢および黒酢もろみ末による血栓症予防の可能性についての基礎的検討2016

    • Author(s)
      大藏直樹、藤井 暁、叶内宏明、根岸文子、大石勝隆、厚味厳一、長野正信
    • Organizer
      第39回日本血栓止血学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Presentation] ノビレチンとその構造類似体の血小板凝集抑制作用と構造との関係2016

    • Author(s)
      藤井文音、株本恵梨、藤田真緒、石橋賢一、忍足鉄太、大藏直樹、厚味厳一
    • Organizer
      第17回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 種々の野菜由来抽出物を用いた野菜の新たな機能の探索2016

    • Author(s)
      藤田理子、金井瑠璃、原実之莉、石橋賢一、上田浩史、大藏直樹、厚味厳一
    • Organizer
      第17回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 特許権2018

    • Inventor(s)
      大藏直樹、長野正信、橋口和典、藤井暁
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2018-118930
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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