Development of cell-penetrating nanotube with hydrophilic and hydrophobic patterned surface for antigen delivery
Project/Area Number |
16K01391
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Kyoto Institute of Technology |
Principal Investigator |
WAKU TOMONORI 京都工芸繊維大学, 分子化学系, 助教 (30548699)
|
Project Period (FY) |
2016-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | ペプチド / ナノチューブ / 自己組織化 / ドッグデリバリーシステム / ドラッグデリバリーシステム / ナノ会合体 / ドラックデリバリーシステム / 両親媒性 / 環状ペプチド / 免疫 |
Outline of Final Research Achievements |
The cyclic peptides consisting of eight amino acid residues with alternating sequence of hydrophilic and hydrophobic groups were synthesized. The cyclic peptides formed fibrous nanostructures in water/organic mixed solvents. The exchange of dispersant to water induced morphological change to sphere. These nanostructures had hydrophobic region on their surface and were taken up by dendritic cells.
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Academic Significance and Societal Importance of the Research Achievements |
ナノ材料は、薬物および遺伝子のデリバリーなどの生医学分野において利用されている。ナノ材料表面の親疎水性バランスは、細胞との相互作用に影響を与える。本研究で作製した親水部と疎水部を表面に併せ持つナノ会合体は、新たなデリバリーキャリアとして有用であり、医療の発展に貢献しうるものと考えられれる。
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Report
(5 results)
Research Products
(10 results)