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A study on elucidation of mechanism and clinical application of transcranial magnetic stimulation with maximum voluntary muscle contraction.

Research Project

Project/Area Number 16K01454
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKagawa University

Principal Investigator

TOUGE TETSUO  香川大学, 医学部, 教授 (80197839)

Co-Investigator(Kenkyū-buntansha) 丸山 敦夫  鹿児島大学, 医歯学総合研究科, 客員研究員 (80117548)
Research Collaborator Takada Tadayuki  
Kume Kodai  
Urai Yoshiteru  
John Rothwell  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords高齢者 / 脳卒中 / 上肢運動麻痺 / 最大筋収縮 / 経頭蓋磁気刺激 / 運動機能訓練法 / 脳磁気刺激 / リハビリテーション / 筋力増強 / 運動麻痺 / 運動機能障害 / 上肢筋力低下 / 神経科学 / 脳神経疾患 / 老化
Outline of Final Research Achievements

We observed that double transcranial magnetic stimulation with maximum voluntary muscle contraction (TMS with MVC) tended to increase amplitudes of motor evoked potentials (MEPs) compared with single TMS with MVC in healthy adults. Based on this result, we carried out a placebo controlled crossover trial to aim to verify the efficacy of double TMS with MVC in patients with chronic hand paresis caused by stroke. As a result, the real stimulation significantly increased maximum pinching force from the first day of stimulation. MEP amplitudes or areas, and scores of pegboard test did not significantly differ between the conditions. Therefore, we think that double TMS with MVC is useful to increase muscle power in patients with chronic hand paresis caused by stroke.

Academic Significance and Societal Importance of the Research Achievements

今回の研究において、最大筋収縮磁気刺激が正常者や脳卒中による慢性的上肢運動麻痺患者の運動機能訓練法として有用であることが示された。また磁気刺激の方法としては単発刺激よりも二連発刺激の有用性が示唆された。この結果に基づき、高齢者の筋力低下や神経疾患による運動麻痺の機能訓練法として、二連発刺激による最大筋収縮時磁気刺激を応用することが可能となり、高齢化社会における要介護者の予防の観点から、研究的意義は極めて高いと思われる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: A case report.2019

    • Author(s)
      Aoe S, Kume K, Takata T, Touge T, Kaneko K, Nakashima I, Deguchi K, Masaki T.
    • Journal Title

      Mult Scler Relat Disord.

      Volume: 28 Pages: 165-166

    • DOI

      10.1016/j.jocn.2019.03.066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexin secretion abnormality involved in excessive somnolence in CNS lymphoma without hypothalamic lesions.2019

    • Author(s)
      Hamada Y, Takata T, Kawakita R, Kobara H, Okada M, Tamiya T, Kanbayashi T, Touge T, Deguchi K, Masaki T.
    • Journal Title

      J Clin Neurosci

      Volume: S0967-5868 Pages: 30421-30427

    • DOI

      10.1016/j.msard.2018.12.035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kume K, Iwama H, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, Fujikawa K, Hirose K, Masugata H, Touge T, Masaki T. Serum microRNA expression profiling in patients with multiple system atrophy.2018

    • Author(s)
      Kume K, Iwama H, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, Fujikawa K, Hirose K, Masugata H, Touge T, Masaki T.
    • Journal Title

      Mol Med Rep

      Volume: 17 Pages: 852-860

    • DOI

      10.3892/mmr.2017.7995

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum microRNA expression profiling in patients with multiple system atrophy.2018

    • Author(s)
      Kume K, Iwama H, Deguchi K, Ikeda K, Takata T, Kokudo Y, Kamada M, Fujikawa K, Hirose K, Masugata H, Touge T, Masaki T.
    • Journal Title

      Mol Med Rep.

      Volume: 17 Pages: 852-860

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute Intermittent Porphyria Presenting with Posterior Reversible Encephalopathy Syndrome, Accompanied by Prolonged Vasoconstriction2017

    • Author(s)
      Takata T, Kume K, Kokudo Y, Ikeda K, Kamada M, Touge T, Deguchi K, Masaki T.
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 6 Pages: 713-717

    • DOI

      10.2169/internalmedicine.56.7654

    • NAID

      130005450342

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Hydrogenation of Unprotected Indoles Catalyzed by η6-Arene/N-Me-sulfonyldiamine-Ru(II) Complexes.2016

    • Author(s)
      Touge, T.; Arai T.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Issue: 35 Pages: 11299-11305

    • DOI

      10.1021/jacs.6b06295

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dialysis-induced Subdural Hematoma in an Arachnoid Cyst Associated with Autosomal Dominant Polycystic Kidney Disease2016

    • Author(s)
      Takata T, Kokudo Y, Kume K, Ikeda K, Kamada M, Touge T, Deguchi K, Masaki T.
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 15 Pages: 2065-2067

    • DOI

      10.2169/internalmedicine.55.6295

    • NAID

      130005254827

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 最大筋収縮時磁気刺激が運動・認知機能に及ぼす影響について2018

    • Author(s)
      峠哲男、土居智彦、出口一志、國土曜平、鎌田正紀
    • Organizer
      第36回日本神経治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 各種芳香刺激が記憶と安静時脳波に及ぼす影響について2018

    • Author(s)
      峠哲男、筒井邦彦、山本麻里奈、清水裕子、
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of transcranial magnetic stimulation with maximum voluntary muscle contraction on somatosensory-auditory event related potentials2018

    • Author(s)
      Touge T, Kokudo Y, Deguchi K, Kamada M, Kume K, Tang, X, Jing-long Wu
    • Organizer
      2018ICME International Conference on Complex Medical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単発刺激と二連発刺激による最大筋収縮時磁気刺激が手指筋の運動誘発電位と摘まみ筋力に及ぼす影響2018

    • Author(s)
      菅原健太郎、土居智和、青江真吾、高田忠幸、出口一志、國土曜平、鎌田正紀、筒井邦彦、峠 哲男
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 最大筋収縮磁気刺激が体性感覚‐聴覚事象関連脳電位に及ぼす影響.2017

    • Author(s)
      峠哲男、出口一志、國土曜平、鎌田正紀、久米広大、糖暁雨、呉景龍.
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of transcranial magnetic brain stimulation with the maximum voluntary muscle contraction (TMS with MVC) on cognitive and motor function in normal subjects.2017

    • Author(s)
      Tetsuo Touge, Yohei Kokudo, Tadayuki Takada, Kodai Kume, Masaki Kamada, Kazushi Deguchi,
    • Organizer
      WCN2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] An evaluation for effects of magnetic brain stimulation with the maximum voluntary muscle contraction (TMS with MVC) on cognitive function in normal subjects2016

    • Author(s)
      TETSUO TOUGE
    • Organizer
      2016 ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      Tochigi
    • Year and Date
      2016-08-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 最大筋収縮時脳磁気刺激による運動・認知機能の変化に関する研究2016

    • Author(s)
      峠哲男
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Book] 今日の治療指針:ミオクローヌス2019

    • Author(s)
      峠 哲男
    • Total Pages
      1
    • Publisher
      医学書院
    • ISBN
      4260036513
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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