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Elucidation of the central neuronal mechanisms of analgesic action of physiotherapy on musculoskeletal pain.

Research Project

Project/Area Number 16K01499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionUniversity of Toyama

Principal Investigator

Takamoto Kouichi  富山大学, 大学院医学薬学研究部(医学), 特命助教 (00553116)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords理学療法 / 筋骨格系疼痛 / 近赤外分光法 / 電気刺激療法 / 理学療法学 / 電気刺激慮法
Outline of Final Research Achievements

We investigated the effects of sine-wave electrical stimulation with three different frequencies (2000, 250, and 5Hz), which selectively stimulate afferent fibers (Aβ、Aδ, and C), at myofascial trigger point in patients with musculoskeletal pain on analgesic effects and cerebral hemodynamic response using near-infrared spectroscopy (NIRS). Sine-wave transcutaneous and needle electrical stimulation with 250 and 5 Hz significantly decreased the subjective feeling of pain after stimulation and Oxy-Hb concentration in the prefrontal region during stimulation compared with 2000Hz.

Academic Significance and Societal Importance of the Research Achievements

慢性筋骨格系疼痛に対する治療法の一つに経皮的電気刺激療法(TENS)、徒手、温熱、鍼等の理学療法がある。これまで多くの臨床試験により理学療法の有効性が報告されており、現代医学において理学療法の重要性が高まっている。しかし、理学療法の共通の問題点として、刺激部位、刺激強度、刺激時間等の様々な刺激パラメーターが存在するが、有効な至適刺激条件が未だ確立されていない。本研究成果により上位中枢性鎮痛効果をもたらす理学療法の有効な刺激パラメーターの設定につながると示唆される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Simultaneous acquisition of magnetic resonance elastography of the supraspinatus and the trapezius muscles.2019

    • Author(s)
      Ito D, Numano T, Takamoto K, Ueki T, Habe T, Igarashi K, Mizuhara K, Nishijo H.
    • Journal Title

      Magn Reson Imaging

      Volume: 57 Pages: 95-102

    • DOI

      10.1016/j.mri.2018.11.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area.2018

    • Author(s)
      Nakamichi N, Takamoto K, Nishimaru H, Fujiwara K, Takamura Y, Matsumoto J, Noguchi M, Nishijo H.
    • Journal Title

      Front Neurol

      Volume: 9 Pages: 939-939

    • DOI

      10.3389/fneur.2018.00939

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compression at myofascial trigger point on chronic neck pain provides pain relief through the prefrontal cortex and autonomic nervous system: a pilot study2017

    • Author(s)
      Morikawa Y, Takamoto K, Nishimaru H, Taguchi T, Urakawa S, Sakai S, Ono T, Nishijo H
    • Journal Title

      Frontiers in Neuroscience

      Volume: 11 Pages: 1-13

    • DOI

      10.3389/fnins.2017.00186

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lip closure training improves eating behaviors and prefrontal cortical hemodynamic activity and decreases daytime sleep in elderly persons.2017

    • Author(s)
      Takamoto K, Saitoh T, Taguchi T, Nishimaru H, Urakawa S, Sakai S, Ono T, Nishijo H.
    • Journal Title

      Journal of Bodywork and Movement Therapies.

      Volume: 印刷中 Issue: 3 Pages: 810-816

    • DOI

      10.1016/j.jbmt.2017.09.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Development of Vibration System for Applying Magnetic Resonance Elastography (MRE) to the Supraspinatus Muscle.2016

    • Author(s)
      Ito D, Numano T, Mizuhara K, Takamoto K, Onishi T, Nishijo H.
    • Journal Title

      Nihon Hoshasen Gijutsu Gakkai Zasshi

      Volume: 72 Issue: 12 Pages: 1222-1229

    • DOI

      10.6009/jjrt.2016_jsrt_72.12.1222

    • NAID

      130005251247

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new technique for MR elastography of the supraspinatus muscle: A gradient-echo type multi-echo sequence.2016

    • Author(s)
      Ito D, Numano T, Mizuhara K, Takamoto K, Onishi T, Nishijo H.
    • Journal Title

      Magn Reson Imaging

      Volume: 34 Issue: 8 Pages: 1181-1188

    • DOI

      10.1016/j.mri.2016.06.003

    • NAID

      120006627270

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 頸部トリガーポイントへの経皮正弦波電気刺激が脳血行動態に及ぼす影響2018

    • Author(s)
      山根裕介、高本考一、酒井大地、酒井重数、小野武年、西条寿夫
    • Organizer
      第48回日本臨床神経生理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 急性期頸部痛及び腰痛患者におけるトリガーポイント発生頻度の検討2018

    • Author(s)
      岩間雄大、高本考一、児玉香菜絵、高坂 忠志、鈴木信幸、滝口幸三、中田人之、阪本仁司、河井好照、酒井重数、西条寿夫
    • Organizer
      第27回日本柔道整復接骨医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頸部トリガーポイントへの経皮電気刺激療法が脳血行動態に及ぼす影響2018

    • Author(s)
      海老名翔平、高本考一、児玉香菜絵、酒井重数、西条寿夫
    • Organizer
      第27回日本柔道整復接骨医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] トリガーポイントに対する筋内正弦波電気刺激における脳血行動態変化2018

    • Author(s)
      山根裕介、高本考一、酒井重数、西条寿夫
    • Organizer
      第27回日本柔道整復接骨医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 汎用MR elastography技術とDixon法の融合2017

    • Author(s)
      沼野智一, 伊東大輝, 大西孝明, 水原和行, 高本考一, 西条寿夫, 三澤雅樹.
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 大西孝明, 沼野智一, 伊東大輝, 水原和行, 高本考一, 波部哲史, 西条寿夫.2017

    • Author(s)
      MR Elastography (MRE)による大腰筋の弾性率測定
    • Organizer
      第73回日本放射線技術学会総会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Integration of MR Elastography and Fat/Water Separation Imaging.2017

    • Author(s)
      Numano T, Ito D, Onishi T, Mizuhara K, Takamoto K, Nishijyo H, Misawa M, Nitta N.
    • Organizer
      International Society for Magnetic Resonance in Medicine ISMRM 25th Annual Meeting & Exhibition.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimal Excitation Location for Magnetic Resonance Elastography of the Supraspinatus Muscle.2017

    • Author(s)
      Ito D, Numano T, Mizuhara T, Takamoto K, Onishi T, Nishijo H.
    • Organizer
      International Society for Magnetic Resonance in Medicine ISMRM 25th Annual Meeting & Exhibition.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性・亜急性腰痛を対象とした腸腰筋に対する腹部手技圧迫療法の効果.2017

    • Author(s)
      小川大貴、長山順太、高本考一、西条寿夫、尾藤何時夢.
    • Organizer
      第26回日本柔道整復接骨医学会.
    • Related Report
      2017 Research-status Report
  • [Presentation] 腰部痛に対するトリガーポイント手技圧迫が脳血行動態に及ぼす影響.2016

    • Author(s)
      児玉香菜絵,高本考一,酒井重数,小野武年,西条寿夫.
    • Organizer
      第25回日本柔道整復接骨医学会学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 伸張性収縮によるラット腓腹筋の筋損傷に対する温熱・徒手療法の効果:組織学的検討.2016

    • Author(s)
      阿部浩明,浦川将,坪島功幸,高本考一,酒井重数,小野武年,西条寿夫.
    • Organizer
      第25回日本柔道整復接骨医学会学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 器具による口唇閉鎖機能訓練が高齢者の口腔機能ならびに日周リズムに及ぼす影響.2016

    • Author(s)
      斉藤剛,高本考一,児玉香菜絵,酒井重数,小野武年,西条寿夫.
    • Organizer
      第25回日本柔道整復接骨医学会学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 頸部痛患者におけるトリガーポイント発生要因の検討2016

    • Author(s)
      永山明日華,馬場優紀子,宇都宮秀美,松下優樹,稲葉将太,高本考一,西条寿夫,尾藤何時夢.
    • Organizer
      第25回日本柔道整復接骨医学会学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性期腰痛患者におけるトリガーポイント発生頻度及び発生要因の検討.2016

    • Author(s)
      山﨑大,大樂純也,中島大輔,篠崎智史,高本考一,西条寿夫,尾藤何時夢.
    • Organizer
      第25回日本柔道整復接骨医学会学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット腓腹筋伸張性収縮後の温熱・徒手療法によるPGC-1α発現量の変化.2016

    • Author(s)
      宮原謙一郎,浦川将,高本考一,田口徹,小野武年,西条寿夫.
    • Organizer
      第21回富山県理学療法学術大会
    • Place of Presentation
      富山大学
    • Related Report
      2016 Research-status Report
  • [Presentation] ロボットスーツHAL (Hybrid Assistive Limb) 装着による下肢運動時の脳血行動態と装着者主観の影響.2016

    • Author(s)
      大田裕也,浦川将,高本考一,石川亮宏,安永好宏,田口徹,小野武年,西条寿夫.
    • Organizer
      第21回富山県理学療法学術大会
    • Place of Presentation
      富山大学
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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