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Nutritional methods to accelerate gastric emptying of carbohydrate solution in healthy subjects - Perspective of prevention of gastrointestinal dysfunction during exercise

Research Project

Project/Area Number 16K01728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionPrefectural University of Hiroshima

Principal Investigator

Yamaoka Endo Masako  県立広島大学, 人間文化学部, 教授 (30336911)

Project Period (FY) 2016-10-21 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords胃内容排出 / 糖質飲料 / 胃腸障害 / 味覚 / 腸トレーニング / 運動 / 高グルコース補給 / 糖質の種類 / 大腿動脈血流量 / 糖質の濃度 / 消化吸収
Outline of Final Research Achievements

This study examined the effects of taste sensations and sweet intensity, sugar type, and gut training on gastric emptying (GE) of carbohydrate solutions. The oral taste sensations were provided by five taste solutions after maltodextrin ingestion. GE was significantly accelerated only by a sweet taste sensation in the oral cavity. In addition, GE was promoted by glucose and fructose of sweetening substances, and the intensity of sweetness was not intensity-dependent, but was the preferred intensity. GE was faster in glucose + fructose solution than a single solution, and the blood flow to active limbs was increased in multiple carbohydrates. Short-term dietary supplementation with glucose accelerated GE of a glucose and prevented GI problem during heavy cycling exercise. These differences of GE in this study may not be related to the autonomic nerve activity and GLP-1.

Academic Significance and Societal Importance of the Research Achievements

本研究では,運動中に摂取する糖質飲料について,胃内容排出(GE)の促進・遅延ならびに胃腸障害という観点からみた,具体的な味の種類・強度,糖質の種類を探索し,腸トレーニングの効果の有無について検討した。また,GE調節因子と推定される自律神経活動,消化管ホルモン,消化管血流量等を測定し,GE調節メカニズムの解明を試みた。本研究成果は,未だ不明な点が多いGE調節因子に関する新たな知見の提供につながり,運動時の胃腸障害の予防・改善によるスポーツ競技力向上のための糖質飲料の新たな提案,GEの遅延が原因で慢性的に食後に胃もたれ等の症状を訴える機能的ディスペプシア患者への栄養学的治療法の提案を期待させた。

Report

(7 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article (12 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 12 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) Remarks (3 results)

  • [Journal Article] Heated Corn Oil and 2,4-Decadienal Suppress Gastric Emptying and Energy Intake in Humans2021

    • Author(s)
      Kashima Hideaki、Honma Ayumi、Kamimura Saori、Nishimura Saki、Sano Takashi、Matsumoto Shoji、Endo Masako、Fukuba Yoshiyuki
    • Journal Title

      Nutrients

      Volume: 13 Issue: 4 Pages: 1304-1304

    • DOI

      10.3390/nu13041304

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carotid baroreflex control of central and peripheral hemodynamics during recovery after moderate leg cycling exercise2020

    • Author(s)
      Kanda Masako、Kajimoto Chie、Kashima Hideaki、Ogino Ai、Miura Akira、Fukuba Yoshiyuki、Endo Masako Yamaoka
    • Journal Title

      Journal of Applied Physiology

      Volume: 128 Issue: 6 Pages: 1477-1486

    • DOI

      10.1152/japplphysiol.00023.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of Oral Sweet Sensations during Consumption of Sweet Food in Humans: Effects on Gastric Emptying Rate, Glycemic Response, Appetite, Food Satisfaction and Desire for Basic Tastes2020

    • Author(s)
      Naomi Kashima, Kanako Kimura, Natsumi Nishitani, Masako Yamaoka Endo, Yoshiyuki Fukuba and Hideaki Kashima
    • Journal Title

      Nutrients

      Volume: 12 Issue: 5 Pages: 1249-1249

    • DOI

      10.3390/nu12051249

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Timing of Nutrient Ingestion after Mild to Moderate Cycling Exercise Does Not Affect Gastric Emptying Rate in Humans2020

    • Author(s)
      Kashima Hideaki、Kamimura Saori、Honma Ayumi、Endo Masako Yamaoka、Miura Akira、Kobayashi Toshio、Fukuba Yoshiyuki
    • Journal Title

      Nutrients

      Volume: 12 Issue: 7 Pages: 2118-2118

    • DOI

      10.3390/nu12072118

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response2019

    • Author(s)
      Kashima Hideaki、Taniyama Kana、Sugimura Kana、Endo Masako Yamaoka、Kobayashi Toshio、Fukuba Yoshiyuki
    • Journal Title

      Nutrition Research

      Volume: 68 Pages: 62-69

    • DOI

      10.1016/j.nutres.2019.06.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Timing of post-resistance exercise nutrient ingestion: effects on gastric emptying and glucose and amino acid responses in humans2018

    • Author(s)
      Kashima H, Sugimura K, Taniyama K, Kondo R, Endo MY, Tanimoto S, Kobayashi T, Miura A, Fukuba Y
    • Journal Title

      British Journal of Nutrition

      Volume: 120 Issue: 9 Pages: 995-1005

    • DOI

      10.1017/s0007114518002398

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Brachial artery blood flow dynamics during sinusoidal leg cycling exercise in humans2017

    • Author(s)
      Fukuba Y, Endo MY, Kondo A, Kikugawa Y, Miura K, Kashima H, Fujimoto M, Hayashi N, Fukuoka Y, Koga S
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 19 Pages: 1-12

    • DOI

      10.14814/phy2.13456

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Timing of postexercise carbohydrate-protein supplementation: roles of gastrointestinal blood flow and mucosal cell damage on gastric emptying in humans2017

    • Author(s)
      Kashima H, Harada N, Miyamoto K, Fujimoto M, Fujita C, Endo MY, Kobayashi T, Miura A, Fukuba Y
    • Journal Title

      Journal of Applied Physiology

      Volume: 23 Issue: 3 Pages: 606-613

    • DOI

      10.1152/japplphysiol.00247.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppression of oral sweet taste sensation with Gymnema sylvestre affects postprandial gastrointestinal blood flow and gastric emptying in humans.2017

    • Author(s)
      Kashima H, Eguchi K, Miyamoto K, Fujimoto M, Endo MY, Aso-Someya N, Kobayashi T, Hayashi N, Fukuba Y.
    • Journal Title

      Chemical Senses

      Volume: 印刷中 Issue: 4 Pages: 295-302

    • DOI

      10.1093/chemse/bjw126

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of soy protein isolate preload on postprandial glycemic control in healthy humans.2016

    • Author(s)
      Kashima H, Uemoto S, Eguchi K, Endo MY, Miura A, Kobayashi T, Fukuba Y.
    • Journal Title

      Nutrition

      Volume: inpress Issue: 9 Pages: 965-969

    • DOI

      10.1016/j.nut.2016.02.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of meal ingestion on blood pressure and regional hemodynamic responses after exercise.2016

    • Author(s)
      Endo MY, Fujihara C, Miura A, Kashima H, Fukuba Y.
    • Journal Title

      Journal of Applied Physiology

      Volume: inpress Issue: 11 Pages: 1343-1348

    • DOI

      10.1152/japplphysiol.00842.2015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Acute effect of oral sensation of sweetness on celiac artery blood flow and gastric myoelectrical activity in humans.2016

    • Author(s)
      Eguchi K, Kashima H, Yokota A, Miura K, Yamaoka Endo M, Hirano H, Tsuji T, Fukuba Y.
    • Journal Title

      Autonomic Neuroscience; Basic & Clinical

      Volume: inpress Pages: 41-5

    • DOI

      10.1016/j.autneu.2016.03.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] グルコースとフルクトース混合飲料が大腿動脈血流量に及ぼす影響2020

    • Author(s)
      山岡(遠藤)雅子,大畑はるな,近藤奈緒,鍛島秀明,三浦朗,福場良之
    • Organizer
      第75回日本体力医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 1)短期間の高グルコース補給は運動時に摂取するグルコース飲料の消化吸収を促進するのか2019

    • Author(s)
      山岡(遠藤)雅子,若槻 鈴華,瀬納 菜見,鍛島 秀明,三浦 朗,福場 良之
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Research-status Report
  • [Remarks] 県立広島大学 研究者紹介 地域創生学部地域創生学科健康科学コース

    • URL

      https://www.pu-hiroshima.ac.jp/uploaded/attachment/16037.pdf

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Remarks] 県立広島大学 研究者紹介 人間文化学部健康科学科

    • URL

      https://www.pu-hiroshima.ac.jp/uploaded/attachment/13959.pdf

    • Related Report
      2019 Research-status Report
  • [Remarks] 県立広島大学 研究者紹介 人間文化学部 健康科学科 山岡(遠藤)雅子

    • URL

      http://www.pu-hiroshima.ac.jp/uploaded/attachment/7873.pdf

    • Related Report
      2016 Research-status Report

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Published: 2016-10-24   Modified: 2023-01-30  

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