| Project/Area Number |
16K01801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
Saeko Imai 京都女子大学, 家政学部, 教授 (00438235)
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| Co-Investigator(Kenkyū-buntansha) |
福井 道明 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30247829)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 食事療法 / 食事時刻 / 夕食 / 間食 / 血糖値 / インスリン / 糖尿病 / 血糖変動 / 栄養指導 |
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| Outline of Final Research Achievements |
Our aim was to explore the acute effect of the late-night-dinner and the divided-dinner on people with and without type 2 diabetes. Each participant wore a continuous glucose monitor for 5 days and consumed identical test meals. Each participant consumed the dinner at 21:00 (D21), 18:00 (D18), and divided dinner (DD: vegetable and rice at 18:00, and vegetable and the main dish at 21:00) in 3 days in cross-over. D21 demonstrated higher incremental glucose peak (IGP) than D18. On the other hand, DD ameliorated the mean amplitude of glycemic excursion (MAGE) than D21. Consuming dinner dividedly could be a practical strategy for reduction of postprandial glucose levels in both people with and without diabetes. We also explored the effect of consuming snacks at different time on glucose excursions in people with type 2 diabetes. Consuming snacks at mid-afternoon demonstrated significantly lower MAGE compared to those at just after lunch or after dinner.
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| Academic Significance and Societal Importance of the Research Achievements |
2型糖尿病患者だけでなく健常者においても、食事の摂取時間の違いが血糖変動及びインスリンに影響を与えたことは、糖尿病の重症化予防だけでなく、健常者に対する健康維持増進、生活習慣病予防のためにも意義があると考える。遅い時刻の夕食や菓子類摂取が避けられないときは、本研究結果が具体的な対処方法のエビデンスとして、生活習慣病予防に役立てることができると考える。
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