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The effect of different time and method of consuming test meal on plasma glucose and hormone levels

Research Project

Project/Area Number 16K01801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKyoto Women's University

Principal Investigator

Saeko Imai  京都女子大学, 家政学部, 教授 (00438235)

Co-Investigator(Kenkyū-buntansha) 福井 道明  京都府立医科大学, 医学(系)研究科(研究院), 教授 (30247829)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords食事療法 / 食事時刻 / 夕食 / 間食 / 血糖値 / インスリン / 糖尿病 / 血糖変動 / 栄養指導
Outline of Final Research Achievements

Our aim was to explore the acute effect of the late-night-dinner and the divided-dinner on people with and without type 2 diabetes. Each participant wore a continuous glucose monitor for 5 days and consumed identical test meals. Each participant consumed the dinner at 21:00 (D21), 18:00 (D18), and divided dinner (DD: vegetable and rice at 18:00, and vegetable and the main dish at 21:00) in 3 days in cross-over. D21 demonstrated higher incremental glucose peak (IGP) than D18. On the other hand, DD ameliorated the mean amplitude of glycemic excursion (MAGE) than D21. Consuming dinner dividedly could be a practical strategy for reduction of postprandial glucose levels in both people with and without diabetes. We also explored the effect of consuming snacks at different time on glucose excursions in people with type 2 diabetes. Consuming snacks at mid-afternoon demonstrated significantly lower MAGE compared to those at just after lunch or after dinner.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病患者だけでなく健常者においても、食事の摂取時間の違いが血糖変動及びインスリンに影響を与えたことは、糖尿病の重症化予防だけでなく、健常者に対する健康維持増進、生活習慣病予防のためにも意義があると考える。遅い時刻の夕食や菓子類摂取が避けられないときは、本研究結果が具体的な対処方法のエビデンスとして、生活習慣病予防に役立てることができると考える。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 6 results,  Invited: 9 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Late-night-dinner deteriorates postprandial glucose and insulin whereas consuming dinner dividedly ameliorates them in patients with type 2 diabetes: A randomized crossover clinical trial2020

    • Author(s)
      Saeko Imai, Yuuki Saito, Shizuo Kajiyama, Ayasa Nitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto Michiaki Fukui
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 29 Pages: 68-76

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 時間栄養学の最新エビデンスー食事の質とリズムと健康のかかわり 夕食時間と健康2020

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      臨床栄養136(3)313-318, 2020

      Volume: 136 Pages: 313-318

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血糖値が気になる人向けの栄養情報 食べ方と食べる時間(解説/特集)2020

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      産業保健と看護

      Volume: 12 Pages: 145-147

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Impact of different timing of consuming sweet snack on postprandial glucose excursions in healthy women2019

    • Author(s)
      Nitta A, Imai S, Kajiyama S, Miyawaki T, Matsumoto S, Ozasa N, Kajiyama S, Hashimoto Y, Tanaka M, Fukui M
    • Journal Title

      Diabetes & Metabolism

      Volume: in press Issue: 4 Pages: 369-374

    • DOI

      10.1016/j.diabet.2018.10.004

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食事の質と量だけでなく食べ方と食べる時刻も血糖指標に影響を与える2019

    • Author(s)
      今井佐恵子、梶山静夫
    • Journal Title

      京都女子大学食物学会誌

      Volume: 74 Pages: 1-9

    • NAID

      120006848631

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Consuming snacks at mid-afternoon improves the mean amplitude of glycaemic excursions compared with consuming snacks just after lunch in people with type 2 diabetes: A randomized cross-over clinical trial2018

    • Author(s)
      Imai S, Kajiyama S, Hashimoto Y, Nitta A, Miyawaki T, Matsumoto S, Ozasa N, Tanaka M, Kajiyama S, Fukui M.
    • Journal Title

      Diabetes & Metabolism

      Volume: 44 Issue: 6 Pages: 482-487

    • DOI

      10.1016/j.diabet.2018.07.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 食べ方と食べる時間が血糖変動に影響を与える2018

    • Author(s)
      今井佐恵子,梶山静夫
    • Journal Title

      化学と生物

      Volume: 56 Pages: 483-489

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 遅い時刻の食事摂取による食後高血糖とその改善へのアプローチ2018

    • Author(s)
      今井佐恵子,梶山静夫
    • Journal Title

      Calm Approach to Glycemic Variation

      Volume: 5 Pages: 25-29

    • Related Report
      2018 Research-status Report
  • [Journal Article] Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in young healthy women: A Randomized Cross-over Clinical Trial2018

    • Author(s)
      Kajiyama S, Imai,S Hashimoto Y, Yamane C, Miyawaki T, Matsumoto S, Ozasa N, Tanaka M, Fukui M.
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 136 Pages: 78-84

    • DOI

      10.1016/j.diabres.2017.11.033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in Patients with Type 2 Diabetes: A Randomized Cross-over Clinical Trial2017

    • Author(s)
      Imai S Kajiyama S, Hashimoto Y, Yamane C, Miyawaki T, Ozasa N, Tanaka M, Fukui M.
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 129 Pages: 206-212

    • DOI

      10.1016/j.diabres.2017.05.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Divided consumption of late-night-dinner improves postprandial glucose, insulin, and the mean amplitude of glycemic excursion in patients with type 2 diabetes.2016

    • Author(s)
      Imai,S Kajiyama S, Hashimoto Y, Yamane C, Miyawaki T, Ozasa N, Tanaka M, Fukui M.
    • Journal Title

      Endocrine Practice

      Volume: 22 Pages: 2-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 遅い時刻の食事は血糖値だけでなくインスリンも増加させる2020

    • Author(s)
      今井佐恵子, 齋藤宥希, 梶山静夫, 新田綺咲,宮脇尚志, 小笹寧子, 梶山真太郎, 橋本善隆, 福井道明
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食べる順番と時間から血糖値を考えるー生活習慣病の栄養指導の理論と実際ー2019

    • Author(s)
      今井佐恵子
    • Organizer
      大阪健康医療部 健康推進室
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 食べる順番と時間から血糖値を考えよう~生活習慣病予防の理論と実際~2019

    • Author(s)
      今井佐恵子
    • Organizer
      第64回大阪産業医学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 夕食の摂取時刻の違いがホルモンに与える影響2019

    • Author(s)
      今井佐恵子, 齋藤 優希 , 梶山静夫 , ,新田綺咲,宮脇尚志, 小笹寧子, 梶山真太郎
    • Organizer
      時間栄養科学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外来2型糖尿病患者に対する食べる順番を主とした栄養指導は5年後の血糖コントロールを改善する2019

    • Author(s)
      新田綺咲、梶山静夫、松田美久子、藤本さおり、宮脇尚志、梶山真太郎、橋本善隆、福井道明、今井佐恵子
    • Organizer
      第22回日本病態栄養学会年次学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] The new dietary approach for patients with diabetes: How and When to eat2018

    • Author(s)
      Saeko Imai, Shizuo Kajiyam, Yoshitaka Hashimoto, Ayasa Nitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Muhei Tanaka, Shintaro Kajiyama, Michiaki Fukui
    • Organizer
      World Congress on Diabetes and Endocrinology 2018.8.22-23.in Rome
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Snacks at post-dinner increases the mean amplitude of glycaemic excursion whereas snacks at mid-afternoon decreases it in young healthy women2018

    • Author(s)
      Saeko Imai, Shizuo Kajiyama, Ayasa Nitta, Takashi Miyawaki, Shinya Matsumoto, Yoshitaka Hashimoto, Neiko Ozasa, Muhei Tanaka, Shintaro Kajiyama, Michiaki Fukui
    • Organizer
      EASD (European Association for the Study of Diabetes) 2018 Berlin, Germany
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 健康長寿をめざす食べ方と食べる時間2018

    • Author(s)
      今井佐恵子
    • Organizer
      兵庫県立大学 食未来エクステンション講座
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in both individuals with and without type 2 diabetes2018

    • Author(s)
      Imai s, Kajiyama S
    • Organizer
      17th Global Diabetes Conference & Nursing Care in Paris France Keynote Forum
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 患者さんが実践しやすい食事療法とは?食べ方の順序による食後高血糖抑制2017

    • Author(s)
      今井佐恵子、梶山静夫
    • Organizer
      第39回日本臨床栄養学会総会ランチョンセミナー 於:千葉県幕張メッセ
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Effect of clinical nutrition in patients with and without diabetes Evidence based research and practice of clinical nutrition2017

    • Author(s)
      Imai S, Kajiyama S
    • Organizer
      5th VINEP Workshop in Hanoi Vietnam
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of clinical nutrition in patients with and without diabetes Evidence based research and practice of clinical nutrition2017

    • Author(s)
      Imai S, Kajiyama S
    • Organizer
      6th VINEP Workshop in Danan Vietnam
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Eating Vegetable Before Carbohydrate Improves Postprandial blood Glucose in Both patients with Type 2 Diabetes and healthy people2017

    • Author(s)
      Imai S
    • Organizer
      韓国国立大学江原大学校
    • Place of Presentation
      韓国国立大学江原大学校 於:春川 韓国
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Eating Vegetable Before Carbohydrate Improves Postprandial blood Glucose in Both patients with Type 2 Diabetes and healthy people2017

    • Author(s)
      Imai S
    • Organizer
      韓国農村振興庁
    • Place of Presentation
      韓国農村振興庁 於:全州 韓国
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Divided consumption of late-night-dinner improves postprandial glucose, insulin, and the mean amplitude of glycemic excursion in patients with type 2 diabetes2016

    • Author(s)
      Imai,S Kajiyama S, Hashimoto Y, Yamane C, Miyawaki T, Ozasa N, Tanaka M, Fukui M
    • Organizer
      The 9th World Congress on Prevention of Diabetes and its complications
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遅い時刻の夕食は分割して摂取すると食後血糖値および血糖変動を抑制する2016

    • Author(s)
      今井佐恵子、梶山静夫、橋本善隆、山根央子、宮脇尚志、小笹寧子、田中武兵、福井道明
    • Organizer
      日本糖尿病学会近畿地方会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report
  • [Book] 時間栄養学2020

    • Author(s)
      柴田重信、田原優、青山晋也、今井佐恵子ほか
    • Publisher
      化学同人
    • Related Report
      2019 Annual Research Report
  • [Book] スペシャリスト直伝!その気にさせる糖尿病療養指導のコツ 夕食を2回に分割すると夜間の血糖値を抑制できる2019

    • Author(s)
      今井佐恵子,梶山静夫
    • Total Pages
      144
    • Publisher
      モダンフィジシャン 新興医学出版社
    • Related Report
      2018 Research-status Report
  • [Book] 食べ方と食べる時間が血糖変動に影響を与える 遅い時刻の夕食に対するアプローチ2018

    • Author(s)
      今井佐恵子, 梶山静夫
    • Total Pages
      8
    • Publisher
      メディカルビューポイント
    • Related Report
      2018 Research-status Report
  • [Book] 糖尿病ケア、秋季増刊 糖尿病の自覚がなく食事療法への意欲がみられない患者2018

    • Author(s)
      今井佐恵子, 梶山静夫
    • Total Pages
      237
    • Publisher
      メディカ出版
    • Related Report
      2018 Research-status Report
  • [Book] 臨床栄養、別冊栄養指導・管理のためのスキルアップシリーズ2018

    • Author(s)
      今井佐恵子、梶山静夫
    • Total Pages
      152
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Remarks] 京都女子大学 教員紹介

    • URL

      http://gyouseki-db.kyoto-wu.ac.jp/Profiles/5/0000427/profile.html

    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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