| Project/Area Number |
16K01941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kawatani Makoto 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (50391925)
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|---|
| Research Collaborator |
Hayashida Marina
Nogawa Toshihiko
Muroi Makoto
Futamura Yushi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がん / 代謝 / 阻害剤 |
|---|
| Outline of Final Research Achievements |
Cancer-specific metabolic pathways are expected to be promising therapeutic targets, but the detailed mechanisms of cancer metabolism remain unclear. We found that human osteosarcoma MG-63 cells can grow without glucose, and thus explored small-molecule inhibitors targeting glucose-independent cancer metabolism using MG-63 cells. By cell-based screening, we found that bikaverin, compound 1, NPL40330 and RCOP8154 from NPDepo chemical library and microbial broth library inhibit glucose-independent growth of MG-63 cells. Moreover, we revealed a part of the mechanism of action of those compounds using chemical biological technique.
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| Academic Significance and Societal Importance of the Research Achievements |
がんの代謝機構は多様性や適応性、不均一性を有しており、詳しいメカニズムは未だ不明な点が多いのが現状である。本研究で得られた化合物は、このような複雑ながん代謝制御機構を理解する有用な化学ツールになる。さらに、今後抗がん剤としての有用性を示せれば、がん特異的な代謝機構を標的とした新たな治療法の確立にもつながる。このように、学術的にも社会的にも本研究の意義は大きいと思われる。
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