A PET study on association between neuroendocrine system and personality traits/character.

• Project/Area Number: 16K01956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Takahashi Kayo 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (90462697)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: PET / オキシトシン / estrogen / 霊長類 / ヒト / エストロジェン / 社会性 / oxytocin / 性ホルモン

Outline of Final Research Achievements

To study the association between neuroendocrine systems and the personality traits and character of human, we are developing novel PET probes which allow us quantitative measurement of molecules in living human body. In the present study, we develop novel PET probes for oxytocin receptor and estrogen receptor imaging. One of the candidate compounds for oxytocin-receptor-imaging PET probe was revealed to bind oxytocin receptor partially, however, there were species differences. A candidate compound for estrogen-receptor-imaging PET probe showed specific binding to estrogen receptor. We continue to work for better compounds as PET probes for oxytocin receptor and estrogen receptor in the brain.

Academic Significance and Societal Importance of the Research Achievements

ヒトは社会的な動物であり、他者と協力しあって生きていくことが求められる。しかし、パーソナリティ障害や発達障害など、社会生活がうまく遂行できない障害がある。今回の研究は、パーソナリティ障害や発達障害に関わるとされるオキシトシン系やestrogen系を生体内で直接観察することを可能とするPETプローブの開発である。この技術を用いて今後パーソナリティ障害や発達障害における脳内メカニズムを明らかにすることが可能になれば、症状の緩和や治療法の探索に結びつけることができる。

Research Products

• [Int'l Joint Research] Uppsala University(スウェーデン)
• [Int'l Joint Research] Uppsala Univ.(スウェーデン)
• [Int'l Joint Research] ウプサラ大学(スウェーデン)
• [Int'l Joint Research] ウプサラ大学(スウェーデン)
• [Journal Article] Association between aromatase in human brains and personality traits (2018)
  • Author(s): Takahashi Kayo、Hosoya Takamitsu、Onoe Kayo、Takashima Tadayuki、Tanaka Masaaki、Ishii Akira、Nakatomi Yasuhito、Tazawa Shusaku、Takahashi Kazuhiro、Doi Hisashi、Wada Yasuhiro、Watanabe Yasuyoshi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41598-018-35065-4
  • Peer Reviewed / Open Access
• [Journal Article] Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ. (2018)
  • Author(s): Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.
  • Journal Title: Anal Biochem Volume: 549 Pages: 174-183
  • DOI: 10.1016/j.ab.2018.04.001
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects. (2017)
  • Author(s): 1.Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 32 Issue: 6 Pages: 293-300
  • DOI: 10.1016/j.dmpk.2017.09.003
  • NAID: 210000187599
  • Peer Reviewed
• [Presentation] A challenge to PET imaging of oxytocin receptor distribution in the brain. (2019)
  • Author(s): Takahashi K, Yokoyama C, Hirahara-Owada S, Niwa T, Suezaki Y, Ose T, Kawasaki A, Takeda C, Hayashinaka E, Wada Y, Kii I, Hayashi T, Hosoya T, Watanabe Y.
  • Organizer: A3 Foresight Program Symposium 2019
  • Int'l Joint Research / Invited
• [Presentation] Brain aromatase imaging and human personality. (2019)
  • Author(s): Takahashi K, Hosoya T, Onoe K, Doi H, Wada Y, Watanabe Y.
  • Organizer: Brain & Brain PET 2019
  • Int'l Joint Research
• [Presentation] Aromatase in the brain and human personality -A PET study. (2019)
  • Author(s): Takahashi K, Hosoya T, Onoe K, Doi H, Wada Y, Watanabe Y
  • Organizer: NEURO2019
• [Presentation] A challenge to PET imaging of oxytocin receptor distribution in the brain. (2018)
  • Author(s): 1.Takahashi K, Yokoyama C, Hirahara-Owada S, Niwa T, Suezaki Y, Ose T, Kawasaki A, Takeda C, Hori Y, Hayashinaka E, Wada Y, Kii I, Hayashi T, Hosoya T, Watanabe Y
  • Organizer: 11th World Molecular Imaging Congress 2018
  • Int'l Joint Research
• [Presentation] Sex difference and indifference in brain aromatase expression by clinical PET study (2016)
  • Author(s): Kayo Takahashi
  • Organizer: 2016 Northeeastern Asian Conference on Molecular Imaging-based Precision Medicine
  • Place of Presentation: Eastern Cloud Hotel, Hanzhou, China
  • Year and Date: 2016-11-10
  • Int'l Joint Research / Invited