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A PET study on association between neuroendocrine system and personality traits/character.

Research Project

Project/Area Number 16K01956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Takahashi Kayo  国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (90462697)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsPET / オキシトシン / estrogen / 霊長類 / ヒト / エストロジェン / 社会性 / oxytocin / 性ホルモン
Outline of Final Research Achievements

To study the association between neuroendocrine systems and the personality traits and character of human, we are developing novel PET probes which allow us quantitative measurement of molecules in living human body. In the present study, we develop novel PET probes for oxytocin receptor and estrogen receptor imaging. One of the candidate compounds for oxytocin-receptor-imaging PET probe was revealed to bind oxytocin receptor partially, however, there were species differences. A candidate compound for estrogen-receptor-imaging PET probe showed specific binding to estrogen receptor. We continue to work for better compounds as PET probes for oxytocin receptor and estrogen receptor in the brain.

Academic Significance and Societal Importance of the Research Achievements

ヒトは社会的な動物であり、他者と協力しあって生きていくことが求められる。しかし、パーソナリティ障害や発達障害など、社会生活がうまく遂行できない障害がある。今回の研究は、パーソナリティ障害や発達障害に関わるとされるオキシトシン系やestrogen系を生体内で直接観察することを可能とするPETプローブの開発である。この技術を用いて今後パーソナリティ障害や発達障害における脳内メカニズムを明らかにすることが可能になれば、症状の緩和や治療法の探索に結びつけることができる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Int'l Joint Research] Uppsala University(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Uppsala Univ.(スウェーデン)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ウプサラ大学(スウェーデン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ウプサラ大学(スウェーデン)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Association between aromatase in human brains and personality traits2018

    • Author(s)
      Takahashi Kayo、Hosoya Takamitsu、Onoe Kayo、Takashima Tadayuki、Tanaka Masaaki、Ishii Akira、Nakatomi Yasuhito、Tazawa Shusaku、Takahashi Kazuhiro、Doi Hisashi、Wada Yasuhiro、Watanabe Yasuyoshi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-018-35065-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.2018

    • Author(s)
      Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.
    • Journal Title

      Anal Biochem

      Volume: 549 Pages: 174-183

    • DOI

      10.1016/j.ab.2018.04.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.2017

    • Author(s)
      1.Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 32 Issue: 6 Pages: 293-300

    • DOI

      10.1016/j.dmpk.2017.09.003

    • NAID

      210000187599

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] A challenge to PET imaging of oxytocin receptor distribution in the brain.2019

    • Author(s)
      Takahashi K, Yokoyama C, Hirahara-Owada S, Niwa T, Suezaki Y, Ose T, Kawasaki A, Takeda C, Hayashinaka E, Wada Y, Kii I, Hayashi T, Hosoya T, Watanabe Y.
    • Organizer
      A3 Foresight Program Symposium 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Brain aromatase imaging and human personality.2019

    • Author(s)
      Takahashi K, Hosoya T, Onoe K, Doi H, Wada Y, Watanabe Y.
    • Organizer
      Brain & Brain PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aromatase in the brain and human personality -A PET study.2019

    • Author(s)
      Takahashi K, Hosoya T, Onoe K, Doi H, Wada Y, Watanabe Y
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] A challenge to PET imaging of oxytocin receptor distribution in the brain.2018

    • Author(s)
      1.Takahashi K, Yokoyama C, Hirahara-Owada S, Niwa T, Suezaki Y, Ose T, Kawasaki A, Takeda C, Hori Y, Hayashinaka E, Wada Y, Kii I, Hayashi T, Hosoya T, Watanabe Y
    • Organizer
      11th World Molecular Imaging Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sex difference and indifference in brain aromatase expression by clinical PET study2016

    • Author(s)
      Kayo Takahashi
    • Organizer
      2016 Northeeastern Asian Conference on Molecular Imaging-based Precision Medicine
    • Place of Presentation
      Eastern Cloud Hotel, Hanzhou, China
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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