Resistance to cognitive behavioral therapy for obsessive-compulsive disorder comorbid with autism spectrum disorder

• Project/Area Number: 16K04344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical psychology
• Research Institution: Chiba University
• Principal Investigator: Hirano Yoshiyuki 千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843)
• Co-Investigator(Kenkyū-buntansha): 大島 郁葉 千葉大学, 子どものこころの発達教育研究センター, 講師 (40625472) ; 中川 彰子 千葉大学, 子どものこころの発達教育研究センター, 教授 (70253424) ; 土屋垣内 晶 千葉大学, 子どものこころの発達教育研究センター, 特任助教 (30778452) ; 大渓 俊幸 千葉大学, 総合安全衛生管理機構, 准教授 (60456118)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 認知行動療法 / 自閉スペクトラム症 / 強迫症 / MRI / 認知機能検査 / 治療抵抗性 / fMRI / 拡散テンソル / 安静時fMRI / 神経心理検査 / 脳画像

Outline of Final Research Achievements

Resistance to cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) has been reported as seen in cases of secondary disorder of autism spectrum disorder (ASD), although CBT is effective in OCD. In this study, we collected MRI (anatomical imaging, diffusion tensor imaging, resting-state functional MRI), clinical and neuropsychological data from patients with OCD who intend to CBT and investigated brain regions and microstructure characteristics in white matter tracts which related with treatment resistance to elucidate the causes of treatment resistance of CBT for patients with OCD with ASD. In the results, we reported that the fractional anisotropy in the left uncinated fasciculus in the white matter showed negative correlations with autistic tendencies and also suggested that the volume in the dorsolateral prefrontal cortex can be the candidate for a predictor of the treatment outcome.

Academic Significance and Societal Importance of the Research Achievements

強迫症は、意志とは無関係に繰り返し頭に浮かび、不快感を生じさせる強迫観念と、繰り返し行われる強迫行為からなる精神疾患である。認知行動療法が有効な疾患であるが、自閉スペクトラム症に併存する強迫症患者には認知行動療法の効果が低いことが知られている。本研究では、強迫症患者の脳の灰白質体積および白質神経線維束の性状を解析した結果、実行機能や社会情動発達に関係する脳部位の形態や機能が認知行動療法の治療効果と関係している可能性を報告した。これらの結果が認知行動療法の治療効果予測指標の同定に役立つことで、強迫症の治療選択に役立つ可能性がある。

Research Products

• [Int'l Joint Research] Vrije Universteit Amsterdam/Radboud University/Max Planck Institute for Psycholinguist(オランダ)
• [Int'l Joint Research] University of Southern California/University of California/Harvard Medical School(米国)
• [Int'l Joint Research] Stellenbosch University/University of Cape Town(南アフリカ)
• [Int'l Joint Research] University of Barcelona/CIBERSAM/IDIBAPS(スペイン)
• [Int'l Joint Research] University of Toronto/University of Calgary/Joseph’s Healthcare(カナダ)
• [Int'l Joint Research]
• [Journal Article] Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD); findings from the ENIGMA-ADHD, -ASD, and -OCD working groups (2020)
  • Author(s): Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Hirano Y, Kuno M, Nakagawa A, Tsuchiyagaito A, Thompson PM, Stein DJ, Buitelaar J, Franke B, van den Heuvel OA et al.
  • Journal Title: American Journal of Psychiatry Volume: In press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration. (2020)
  • Author(s): van den Heuvel OA, Boedhoe PSW, Hirano Y, Thompson PM, Stein DJ et al.
  • Journal Title: Human Brain Mapping Volume: In press Issue: 1 Pages: 23-36
  • DOI: 10.1002/hbm.24972
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study. (2020)
  • Author(s): Fujioka T, Tsuchiya KJ, Saito M, Hirano Y, Matsuo M, Kikuchi M, Maegaki Y, Choi D, Kato S, Yoshida T, Yoshimura Y, Ooba S, Mizuno Y, Takiguchi S, Matsuzaki H, Tomoda A, Shudo K, Ninomiya M, Katayama T, Kosaka H.
  • Journal Title: Molecular Autism Volume: 11 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s13229-020-00321-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings from the ENIGMA Consortium (2019)
  • Author(s): Kong XZ, Boedhoe PSW, Hirano Y, Kuno M, Nakagawa A, Tsuchiyagaito A, Thompson PM, Stein DJ, van den Heuvel OA, Francks C et al.
  • Journal Title: Biological Psychiatry Volume: In press Issue: 12 Pages: 1022-1034
  • DOI: 10.1016/j.biopsych.2019.04.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognosis Prediction Using Therapeutic Agreement of Video Conference?Delivered Cognitive Behavioral Therapy: Retrospective Secondary Analysis of a Single-Arm Pilot Trial (2019)
  • Author(s): Matsumoto Kazuki、Yoshida Tokiko、Hamatani Sayo、Sutoh Chihiro、Hirano Yoshiyuki、Shimizu Eiji
  • Journal Title: JMIR Mental Health Volume: 6 Issue: 11 Pages: e15747-e15747
  • DOI: 10.2196/15747
  • Peer Reviewed / Open Access
• [Journal Article] Insensitivity of the auditory mismatch negativity (MMN) in human classical fear conditioning and extinction (2019)
  • Author(s): Kurayama T, Matsuzawa D, Hirano Y, Shimizu E
  • Journal Title: Neuroreport Volume: 30 Issue: 7 Pages: 468-472
  • DOI: 10.1097/wnr.0000000000001221
  • Peer Reviewed
• [Journal Article] 認知行動療法と脳科学 (2019)
  • Author(s): 平野好幸
  • Journal Title: 行動科学 Volume: 57 Pages: 89-95
  • NAID: 40022319402
  • Peer Reviewed
• [Journal Article] Internet-Based Cognitive Behavioral Therapy via Videoconference for Patients With Bulimia Nervosa and Binge-Eating Disorder: Pilot Prospective Single-Arm Feasibility Trial (2019)
  • Author(s): Hamatani Sayo、Numata Noriko、Matsumoto Kazuki、Sutoh Chihiro、Ibuki Hanae、Oshiro Keiko、Tanaka Mari、Setsu Rikukage、Kawasaki Yohei、Hirano Yoshiyuki、Shimizu Eiji
  • Journal Title: JMIR Formative Research Volume: 3 Issue: 4 Pages: e15738-e15738
  • DOI: 10.2196/15738
  • Peer Reviewed / Open Access
• [Journal Article] Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study. (2018)
  • Author(s): Numata N, Hirano Y, Sutoh C, Matsuzawa D, Takeda K, Setsu R, Shimizu E, Nakazato M.
  • Journal Title: Eat Weight Disord, in press Volume: - Issue: 1 Pages: 1-9
  • DOI: 10.1007/s40519-018-0500-7
  • Peer Reviewed
• [Journal Article] White matter features associated with autistic traits in obsessive-compulsive disorder. (2018)
  • Author(s): Kuno M, Hirano Y, Nakagawa A, Asano K, Oshima F, Nagaoka S, Matsumoto K, Masuda Y, Iyo M, Shimizu E.
  • Journal Title: Frontiers in Psychiatry Volume: 9 Pages: 216-216
  • DOI: 10.3389/fpsyt.2018.00216
  • Peer Reviewed / Open Access
• [Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R). (2018)
  • Author(s): Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
  • Journal Title: Curr Psychol Volume: In press Issue: 1 Pages: 1-7
  • DOI: 10.1007/s12144-017-9741-2
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome. (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Front Psychiatry Volume: 8 Pages: 143-143
  • DOI: 10.3389/fpsyt.2017.00143
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder (2017)
  • Author(s): Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Brain Imaging and Behavior Volume: 印刷中 Issue: 5 Pages: 1326-33
  • DOI: 10.1007/s11682-016-9611-9
  • Peer Reviewed
• [Journal Article] Relationship between symptom dimensions and white matter alterations in OCD (2017)
  • Author(s): Yagi M, Hirano Y, Nakazato M, Nemoto K, Ishikawa K, Sutoh C, Miyata H, Matsumoto J, Matsumoto K, Masuda Y, Obata T, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Acta Neuropsychiatrica Volume: 印刷中 Issue: 3 Pages: 153-163
  • DOI: 10.1017/neu.2016.45
  • Peer Reviewed
• [Presentation] Prefrontal cortical thickness is associated with response to cognitive-behavioral therapy in children with obsessive-compulsive disorder (2019)
  • Author(s): Soriano-Mas C, Bertolin S, Martinez-Zalacain I, Boedhoe PSW, Hirano Y, Thompson P, Menchon JM, Stein DJ, van den Heuve OA
  • Organizer: The First European Congress on Clinical Psychology and Psychological Treatment of EACLIPT
  • Int'l Joint Research
• [Presentation] Prefrontal cortical thickness is associated with response to cognitive-behavioural therapy in children and adolescents with OCD (2019)
  • Author(s): Bertolin Triquell S, Martinez-Zalacain I, Boedhoe PSW, Alonso P, Brennan BP, Fitzgerald KD, Hirano Y et al.
  • Organizer: 32nd European College of Neuropsychopharmacology
  • Int'l Joint Research
• [Presentation] Comparison of Neuropsychological Function in Social Anxiety Disorder and Healthy Controls (2019)
  • Author(s): Okawa S, Hamatani S, Arai H, Nihei M, Yoshida T, Takahashi J, Hirano Y
  • Organizer: 9th World Congress of Behavioural & Cognitive Therapies
  • Int'l Joint Research
• [Presentation] Correlations between the Clinical Profiles and the Profile of the Wechsler Adult Intelligence Scale-III in Obsessive Compulsive Disorder (2019)
  • Author(s): Hamatani S, Nihei M, Hayashi Y, Tsuchiyagaito A, Nakagawa A, Shimizu E, Hirano Y
  • Organizer: 9th World Congress of Behavioural and Cognitive Therapies
  • Int'l Joint Research
• [Presentation] Dependence of slice selection on cerebral blood flow signals during visual stimulation: a study using simultaneous ASL and bold measurement (2019)
  • Author(s): Ikoma Y, Hirano Y, Tachibana A, Tachibana Y, Murata K, Higashi T, Obata T
  • Organizer: 29th International Symposium on Cerebral Blood Flow, Metablism and Function and 14th International Symporium Conference on Quantification of Brain Function with PET
  • Int'l Joint Research
• [Presentation] ディープ ラーニングを用いた課題時fMRIの高精度化に向けた初期的検討 (2019)
  • Author(s): 大田淳子、立花泰彦、平野好幸、梅原健輔、影山肇、生駒洋子、大場久照、小畠隆行
  • Organizer: 第47回日本放射線技術学会秋季学術大会
• [Presentation] T2*WIを代替訓練データとして安静時fMRIを深層学習により高解像度化する手法の初期検討 (2019)
  • Author(s): 影山肇、立花泰彦、大田淳子、梅原健輔、平野好幸、小畠隆行、近藤啓介、志村一男
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] 視覚刺激時fMRI信号と脳血流変化の空間的時間的差異 (2019)
  • Author(s): 城谷良太、生駒洋子、平野好幸、立花泰彦、村田勝俊、東達也、小畠隆行、粟井和夫
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] 強迫症・不安症の認知行動療法の作用機序と治療効果予測：脳画像による検討 (2019)
  • Author(s): 平野好幸
  • Organizer: 第23回日本精神保健・予防学会学術集会
• [Presentation] 認知行動療法の治療効果予測に向けて：脳画像研究からの検討 (2018)
  • Author(s): 平野好幸
  • Organizer: 日本認知・行動療法学会第44回大会
• [Presentation] 認知行動療法と脳画像 (2018)
  • Author(s): 平野好幸
  • Organizer: 第34回日本行動科学会ウィンターカンファレンス
  • Invited
• [Presentation] 症状次元を考慮した強迫症の脳画像研究 (2017)
  • Author(s): 平野好幸
  • Organizer: 第9回日本不安症学会学術大会抄録集
  • Place of Presentation: 九州大学医学部百年講堂（福岡県福岡市）
  • Year and Date: 2017-03-10
  • Invited
• [Presentation] Neurostructural predictors of cognitive behavioral therapy (CBT) for obsessive-compulsive disorder: implications for the integration of neurofeedback training and CBT (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Tazaki M, Nakagawa A
  • Organizer: 2017 ISNR Annual Conference
  • Int'l Joint Research
• [Presentation] OCD with and without ASD: Do differential brain alternative predict CBT outcomes? (2017)
  • Author(s): Tsuchiyagaito A, Hirano Y, Shimizu E, Nakagawa A
  • Organizer: 24th Annual OCD Conference
  • Int'l Joint Research
• [Presentation] より良い治療効果を得るために―自閉スペクトラム症を併存する強迫症に対する認知行動療法の効果と関連する脳部位を用いたモデル検討― (2017)
  • Author(s): 土屋垣内晶、平野好幸、竹林由武、清水栄司、中川彰子
  • Organizer: 第44回日本脳科学学会
• [Presentation] Reliability and validity of the Japanese version of OCI-R (2016)
  • Author(s): 3.Koike H, Oshima F, Asano K, Nishinaka H, Hirano Y, Shimizu E, Nakagawa A
  • Organizer: 2016 International Symposium on Neurodegenerative Diseases & the 43rd Annual Conference of Japan Brain Science Society
  • Place of Presentation: Xi'an, China
  • Year and Date: 2016-11-10
  • Int'l Joint Research / Invited
• [Presentation] Do neuropsychological tests give a clue for ASD tendency in adult OCD patients? (2016)
  • Author(s): 2.Miyata H, Hirano Y, Asano K, Oshima F, Matsumoto J, Nagaoka M, Koike H, Shimizu E, Nakagawa A
  • Organizer: 46th annual Congress of the European Association for Behavioural and Cognitive Therapies
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター: