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Effects of electrical stimulation on neural mechanisms involved in cognitive function

Research Project

Project/Area Number 16K04443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Watanabe Yumiko  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (20425739)

Project Period (FY) 2016-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords脳 / 認知機能 / 認知症 / 電気刺激 / 可塑性 / 長期増強 / 経頭蓋電気刺激 / 記憶
Outline of Final Research Achievements

Transcranial electrical stimulation, a noninvasive method of applying weak electric currents to the brain, has attracted attention for its effectiveness in improving cognitive dysfunction. However, there are many unknowns regarding the effects of stimulation on brain activity and neural circuits. In order to effectively utilize this method, it is necessary to clarify the above points. Therefore, in order to clarify how transcranial electrical stimulation affects neural circuits involved in cognitive functions, we focused on neural pathways important for higher cognitive functions and memory, and investigated the effects of transcranial electrical stimulation. The results revealed that transcranial electrical stimulation of the frontal lobes produces long-term potentiation-like plastic changes.

Academic Significance and Societal Importance of the Research Achievements

非侵襲的に脳に微弱な電流を流す経頭蓋電気刺激という方法が、認知機能障害の改善に有効ではないかと注目されているものの、刺激による脳活動や神経回路への影響など不明な点も多い。本研究で、刺激により認知機能に関わる神経回路に可塑的な変化が生じることが明らかになった。本研究の成果は認知機能低下の改善などで刺激のタイミングなどを検討する際の基礎的データとして重要な結果となった。

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2023 2021 2020 2019 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (10 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Hippocampal-prefrontal long-term potentiation-like plasticity with transcranial direct current stimulation in rats2023

    • Author(s)
      Yumiko Watanabe, Shinnosuke Dezawa, Hiroyuki Takei, Kazuaki Nagasaka, Ichiro Takashima
    • Journal Title

      Neurobiology of Learning and Memory

      Volume: 201 Pages: 107750-107750

    • DOI

      10.1016/j.nlm.2023.107750

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats2021

    • Author(s)
      Dezawa Shinnosuke、Nagasaka Kazuaki、Watanabe Yumiko、Takashima Ichiro
    • Journal Title

      Experimental Neurology

      Volume: 335 Pages: 113493-113493

    • DOI

      10.1016/j.expneurol.2020.113493

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change of information represented by thalamic mediodorsal neurons during the delay period2018

    • Author(s)
      Watanabe Yumiko、Funahashi Shintaro
    • Journal Title

      NeuroReport

      Volume: 29 Issue: 6 Pages: 466-471

    • DOI

      10.1097/wnr.0000000000000998

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Topographical projections from the nucleus basalis magnocellularis (Meynert) to the frontal cortex: A voltage-sensitive dye imaging study in rats2017

    • Author(s)
      Nagasaka Kazuaki、Watanabe Yumiko、Takashima Ichiro
    • Journal Title

      Brain Stimulation

      Volume: 10 Issue: 5 Pages: 977-980

    • DOI

      10.1016/j.brs.2017.06.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood-brain barrier derangement after electrical brain stimulation2017

    • Author(s)
      Watanabe Yumiko、Nik-Mohd-Afizan N.A.R.、Takashima Ichiro
    • Journal Title

      Journal of Neurology and Neuromedicine

      Volume: 2 Issue: 10 Pages: 1-5

    • DOI

      10.29245/2572.942x/2017/10.1162

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety of anodal transcranial direct current stimulation with respect to blood-brain barrier pearmeability in the rat2017

    • Author(s)
      Nik-Mohd-Afizan N.A.R.、Watanabe Yumiko、Takashima Ichiro
    • Journal Title

      Curr Neurobiology

      Volume: 8 Pages: 34-39

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The nucleus basalis of Meynert modulates somatosensory neural activity and tactile sensitivity in rats2020

    • Author(s)
      出澤 真乃介、長坂和明、渡辺 由美子、高島 一郎
    • Organizer
      第43回日本神 科学大会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modulation of somatosensory evoked potential by cholinergic basal forebrain in rat2019

    • Author(s)
      出澤 真乃介、長坂和明、渡辺 由美子、高島 一郎
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 前脳基底部刺激による感覚皮質神経応答の調節2019

    • Author(s)
      出澤 真乃介、長坂和明、渡辺 由美子、高島 一郎
    • Organizer
      第56回日本リハビリテーション医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Hippocampal-prefrontal plasticity with transcranial direct current stimulation2019

    • Author(s)
      Yumiko Watanabe, Hiroyuki Takei, Kazuaki Nagasaka, Ichiro Takashima
    • Organizer
      9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットマイネルト核への電気刺激直後の前肢刺激が前頭皮質に誘発する神経活動2018

    • Author(s)
      出澤 真乃介、長坂和明、渡辺由美子、高島一郎
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットマイネルト核への連発電気刺激が誘発する前頭葉の神経活動解析2018

    • Author(s)
      出澤 真乃介、長坂和明、渡辺由美子、高島一郎
    • Organizer
      脳機能とリハビリテーション研究会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 物体再認課題を用いた経頭蓋電気刺激法の評価2017

    • Author(s)
      渡辺由美子、武井宙人、高島一郎
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Modulating neural plasticity with transcranial direct current stimulation2017

    • Author(s)
      Takei H、Watanabe Y、Takashima I
    • Organizer
      SICEライフエンジニアリング部門シンポジウム (第32回生体・生理工学シンポジウム)
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of neural responses in rat frontal cortex evoked by single or burst stimulation of the nucleus basalis of Meynert2017

    • Author(s)
      Dezawa S、Nagasaka K、Watanabe Y、Takashima I
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Assessment of brain stimulations using the novel object recognition task in rats2016

    • Author(s)
      Takei H, Watanabe Y, Kunori N, Takashima I
    • Organizer
      第31回生体・生理工学シンポジウム
    • Place of Presentation
      大阪国際交流センター(大阪市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2024-01-30  

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