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Mathematical studies on cell aggregates

Research Project

Project/Area Number 16K05523
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionNihon University

Principal Investigator

NOSE (NONOMURA) Makiko  日本大学, 生産工学部, 教授 (20333320)

Project Period (FY) 2016-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsフェーズフィールド法 / 細胞集団 / 形態形成 / 細胞運動 / フェーズフィールドモデル / 細胞分裂 / 細胞 / 数理モデル / 細胞移動 / 数理生物
Outline of Final Research Achievements

In order to construct a mathematical model of cell shape that takes into account the internal state of the cell and molecular localization, numerical calculations were performed for oocytes and cysts, incorporating the calculation of division planes that take into account molecular localization. To develop a mathematical model of cell population dynamics, we analyzed experimental images of cell populations using particle image velocimetry (PIV) and machine learning to quantify the characteristics of cell population dynamics. We also devised a new method for extracting cell contours. In the future, we intend to use the findings of this study to conduct mathematical research to further our understanding of cell morphogenesis and functional expression.

Academic Significance and Societal Importance of the Research Achievements

本研究では細胞集団を表すフェーズフィールドモデルに細胞分裂や分子の局在を汲み込み,さらにそれを用いて卵割や嚢胞などの数値計算を行った.また,PIVや粒子法,機械学習などのさまざまな手法を用いて,細胞集団運動の特性を数値化し,今後の細胞集団運動の数理モデル開発への道筋をつけた.本研究成果は,個々の細胞が形態形成や機能発現に与える影響の解明に向けた数理的研究への展開が期待できる.

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2023 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results)

  • [Int'l Joint Research] Strasbourg University(フランス)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Copenhagen(デンマーク)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] MPI(ドイツ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Strasbourg University(フランス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Copenhagen(デンマーク)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] MPI(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] A Facile Assay of Epithelial-mesenchymal Transition Based on Cooperativity Quantification of Cellular Autonomous Motions2020

    • Author(s)
      YAMAMOTO Shota、MIYAMA Tatsuya、KOMODA Takafumi、SUGAWARA Michiko、NONOMURA Makiko、NAKANISHI Jun
    • Journal Title

      Analytical Sciences

      Volume: 36 Issue: 2 Pages: 263-268

    • DOI

      10.2116/analsci.19P233

    • NAID

      130007796068

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2020-02-10
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical study on spindle positioning using phase field method2019

    • Author(s)
      Akiyama, M. Nonomura, M. Tero, A. Kobayashi, R.
    • Journal Title

      Physical Biology

      Volume: 16 Issue: 1 Pages: 016005-016005

    • DOI

      10.1088/1478-3975/aaee45

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 粒子画像流速測定法を用いた創傷治癒における集団細胞運動解析2023

    • Author(s)
      宇田川 武大,松本 直弥, 野々村 真規子,菅原 路子
    • Organizer
      関東学生会第 62 回学生員卒業研究発表講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of collective cell migration on geometrically constrained circular region using Particle Image Velocimetry2019

    • Author(s)
      Takumi Hanzawa, Tatsuya Miyama, Makiko Nonomura, Jun Nakanishi, Michiko Sugawara
    • Organizer
      3rd International Symposium on Nanoarchitectonics for Mechanobiology
    • Related Report
      2018 Research-status Report
  • [Presentation] The Study of Polymerization and Depolymerization of Actin Filaments and Its Effect to Shape of Cell Membrane2018

    • Author(s)
      Arifumi Fushimi, Michiko Sugawara, Makiko Nonomura
    • Organizer
      3rd International Symposium on Nanoarchitectonics for Mechanobiology
    • Related Report
      2018 Research-status Report
  • [Presentation] The study of polymerization and depolymerization of actin filament2018

    • Author(s)
      Arifumi Fushimi, Makiko Nonomura, Michiko Sugawara
    • Organizer
      International concerence on APEF 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 上皮間葉転換阻害剤のスクリーニングに向けた細胞集団性の定量化法2017

    • Author(s)
      深山達也, 野々村真規子, 菰田貴文, 菅原路子, 中西淳
    • Organizer
      日本分析化学年会第66年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 光応答基板と数理解析に基づく細胞集団性の評価2017

    • Author(s)
      深山達也, 野々村真規子, 菰田貴文, 菅原路子, 中西淳
    • Organizer
      つくば医工連携フォーラム2017
    • Place of Presentation
      国立研究開発法人物質・材料研究機構
    • Related Report
      2016 Research-status Report
  • [Presentation] 光応答基板と画像流速解析を用いた細胞集団移動現象定量化法2016

    • Author(s)
      深山達也, 菰田貴文, 菅原路子, A.Abdellatef Shimaa, 山口和夫, 野々村真規子, 中西淳
    • Organizer
      日本分析化学会第65年会
    • Place of Presentation
      北海道大学工学部(札幌市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantification of epithelial-mesenchymal transition by using photoactivatable substrates and particle image velocimetry2016

    • Author(s)
      Tatsuya Miyama, Makiko Nonomura, Takafumi Komoda, Michiko Sugawara, Jun Nakanishi
    • Organizer
      RSC Tokyo International Conference 2016
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Improved Particle Image Velocimetry for Collective Cell Migration Studies2016

    • Author(s)
      Takafumi Komoda, Michiko Sugawara, Tatsuya Miyama, Makiko Nonomura, Jun Nakanishi
    • Organizer
      International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      国立研究開発法人物質・材料研究機構
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantification of epithelial-mesenchymal transition on photoactivatable substrates by means of particle image velocimetry2016

    • Author(s)
      Tatsuya Miyama, Makiko Nonomura, Takafumi Komoda, Michiko Sugawara, Jun Nakanishi
    • Organizer
      International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      国立研究開発法人物質・材料研究機構
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2024-01-30  

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