• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of sono-activatable photosensitizer for photodynamic therapy of cancer

Research Project

Project/Area Number 16K05741
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional solid state chemistry
Research InstitutionGunma University

Principal Investigator

Horiuchi Hiroaki  群馬大学, 大学院理工学府, 准教授 (00334136)

Co-Investigator(Kenkyū-buntansha) 奥津 哲夫  群馬大学, 大学院理工学府, 教授 (20261860)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords光線力学療法 / 一重項酸素 / 光増感剤 / 超音波 / 活性制御 / ON/OFFスイッチング / 会合体 / 自己消光 / 光線力学的療法
Outline of Final Research Achievements

Photodynamic therapy is one of a non-invasive cancer treatment using photosensitization of singlet oxygen. However, it is difficult to reduce the distribution of photosensitizer to normal tissue to zero, and singlet oxygen is also produced even in normal tissue to induce side effects.
In order to solve this problem, we will introduce an ON / OFF switching mechanism to photosensitizers, and aim to develop drugs that do not function in normal tissues and function only in cancer tissues. Moreover, we tried to induce the ON / OFF switching by sonication, which is one of a low invasive trigger. Specifically, aggregates of photosensitizers will be prepared to produce the OFF state by intramolecular self-quenching. The OFF to ON switching will be induced by the disaggregation by sonocation.

Academic Significance and Societal Importance of the Research Achievements

現在の主力のガン治療法は強力である反面、副作用も大きく、患者の生活の質の改善は重要である。光と薬剤を組み合わせた光線力学療法は非侵襲的なガン治療法として期待されているものの、明所においては副作用が生じ、患者は治療後に暗所で長期間過ごす必要があるなどの問題を抱えている。本課題では光線力学療法の非侵襲性を飛躍的に向上させることを目指しており、将来的に本課題のメカニズムを導入できれば、日帰り治療が可能な、手軽なガン治療法として普及できる可能性を有する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (49 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (41 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Adsorption Behavior of Curcumin onto Cetyltrimethylammonium Chloride Reverse Micelles Immobilized on a Glass Surface As Studied by Polarized Visible Attenuated Total Reflection Spectrometry with a Glass Slab Optical Waveguide2019

    • Author(s)
      T. Nishiwaki, K. Sato, K Tsunoda, H. Horiuchi, T. Fujiwara
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 4 Pages: 465-469

    • DOI

      10.2116/analsci.18N016

    • NAID

      130007629978

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-04-10
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of the ON/OFF switching performance of a pH-activatable porphyrin derivative by the introduction of phosphorus(V)2019

    • Author(s)
      Hiroaki Horiuchi、Masataka Isogai、Kazutaka Hirakawa、Tetsuo Okutsu
    • Journal Title

      ChemPhotoChem

      Volume: 3 Issue: 3 Pages: 138-144

    • DOI

      10.1002/cptc.201800248

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of the Orthogonal Structure Between Porphyrin and Aniline Moieties on the pH-Activatable Porphyrin Derivative for Photodynamic Therapy2018

    • Author(s)
      H. Horiuchi, A. Hirabara, T. Okutsu
    • Journal Title

      J. Photochem. Photobiol. A

      Volume: 365 Pages: 60-66

    • DOI

      10.1016/j.jphotochem.2018.07.034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Unique Optical Properties of Selenophenyl BODIPYs and Their Linear Oligomers2018

    • Author(s)
      Taguchi Daisuke、Nakamura Takashi、Horiuchi Hiroaki、Saikawa Makoto、Nabeshima Tatsuya
    • Journal Title

      The Journal of Organic Chemistry

      Volume: in press Issue: 9 Pages: 5331-5337

    • DOI

      10.1021/acs.joc.8b00782

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photo sensitization reaction-induced crystallization of lysozyme2017

    • Author(s)
      Utsumi Maiko、Horiuchi Hiroaki、Okutsu Tetsuo
    • Journal Title

      Journal of Photochemistry and Photobiology A: Chemistry

      Volume: 344 Pages: 223-227

    • DOI

      10.1016/j.jphotochem.2017.05.027

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extension of pai-System of Silylated Porphyrin Derivative for Photodynamic Therapy2016

    • Author(s)
      Hiroaki Horiuchi, Asumi Sakai, Shingo Akiyama, Remi Ikeda, Satoshi Ito, Masaru Furuya, Yuta Gomibuchi, Muneki Ichikawa, Toshitada Yoshihara, Seiji Tobita, Tetsuo Okutsu
    • Journal Title

      Journal of Photochemistry and Photobiology A: Chemistry

      Volume: 339 Pages: 19-24

    • DOI

      10.1016/j.jphotochem.2017.02.015

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] pH-Response Optimization of Amino-Substituted Tetraphenylporphyrin Derivatives as pH-Activatable Photosensitizers2016

    • Author(s)
      Horiuchi, Hiroaki; Kuribara, Ryota; Hirabara, Atsuki; Okutsu, Tetsuo
    • Journal Title

      The Journal of Physical Chemistry

      Volume: 120 Issue: 28 Pages: 5554-5561

    • DOI

      10.1021/acs.jpca.6b05019

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] ポルフィリン誘導体による一重項酸素生成のトリプルpH応答特性2019

    • Author(s)
      堀内宏明・田島和哉・奥津哲夫
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Protein crystallization induced by gap mode surface plasmon resonance with liner polarized light2018

    • Author(s)
      Tetsuo Okutsu, Taku Yasue, Remina Ohtsuka, Hiroaki Horiuch
    • Organizer
      10th Asian Photochemistry Conference (APC)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Triple pH-Activatable Photosensitizer for Photodynamic Theray2018

    • Author(s)
      H. Horiuchi, K. Tajima, S. Torii, T. Okutsu
    • Organizer
      GUMI 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金ナノ粒子の表面プラズモン共鳴により誘起される結晶化機構の解明2018

    • Author(s)
      村上未来・安江琢・山越美季・堀内宏明・奥津哲夫
    • Organizer
      第47回結晶成長国内会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 銀ナノ粒子の表面プラズモン共鳴を用いたタンパク質の結晶化2018

    • Author(s)
      伊藤明日香・堀内宏明・奥津哲夫
    • Organizer
      第47回結晶成長国内会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金薄膜により誘起される有機化合物の結晶化機構の解明2018

    • Author(s)
      山越美季・横川拓哉・堀内宏明・天野一幸・奥津哲夫
    • Organizer
      第47回結晶成長国内会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金薄膜を用いた有機化合物の結晶化誘起の機構解明2018

    • Author(s)
      山越美季・横川拓哉・堀内宏明・天野一幸・奥津哲夫
    • Organizer
      第27回有機結晶シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腫瘍に高発現する還元型グルタチオンにより活性制御可能なシリルポルフィリンの研究2018

    • Author(s)
      武藤 槙吾・堀内 宏明・久保田 諒・奥津 哲夫
    • Organizer
      2018年光化学討論
    • Related Report
      2018 Annual Research Report
  • [Presentation] アミノインドールを消光剤として用いたpH応答性光増感剤の開発2018

    • Author(s)
      田島 和哉・堀内 宏明・奥津哲夫
    • Organizer
      2018年光化学討論
    • Related Report
      2018 Annual Research Report
  • [Presentation] pH応答性ポルフィリン誘導体のON/OFFスイッチング特性の改良2018

    • Author(s)
      堀内 宏明・磯貝 将孝・田島 和哉・平川 和貴・奥津 哲夫
    • Organizer
      2018年光化学討論
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光線力学療法への応用を志向したpH応答性 リン(V)ポルフィリンの開発2018

    • Author(s)
      堀内 宏明・磯貝 将孝・平川 和貴・奥津 哲夫
    • Organizer
      第40回日本光医学・光生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 銀ナノ粒子および金ナノ粒子の表面プラズモン共鳴を用いたタンパク質の結晶化2018

    • Author(s)
      伊藤明日香・安江琢・堀内宏明・奥津哲夫
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Water Soluble pH-Activatable Photosensitizing Drug for Photodynamic Therapy of Cancer2018

    • Author(s)
      H. Horiuchi, M. Isogai, K. Hirakawa, T. Okutsu
    • Organizer
      Gunma International Symposium 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of intramolecular orthogonality of acid-responsive photosensitizer on ON/OFF switching of singlet oxygen generation2018

    • Author(s)
      M. Hamano, H. Horiuchi, A. Hirabara, R. Kuribara, T. Okutsu
    • Organizer
      Gunma International Symposium 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Delelopment of the glycosylated photosensitiser for the application to photoimmunotherapy2018

    • Author(s)
      R. Kubota, H. Horiuchi, N. Ishii, K. Sano, I. Matsuo, T. Okutsu
    • Organizer
      Gunma International Symposium 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of Nanodrop as oxygen carrier for photodynamic therapy2018

    • Author(s)
      R. Hoshino, H. Horiuchi, T. Okutsu
    • Organizer
      Gunma International Symposium 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Protein Crystalization using alignment by electric field and molecule adsorption on gold nanoparticles2018

    • Author(s)
      T. Yasue, H. Horiuch, T. Okutsu
    • Organizer
      Protein Crystalization using alignment by electric field and molecule adsorption on gold nanoparticles
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] pH応答性リン(V)ポルフィリン誘導体の光増感特性2018

    • Author(s)
      堀内 宏明, 磯貝 将孝, 平川 和貴, 奥津 哲夫
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 金薄膜により誘起される有機化合物の結晶化2018

    • Author(s)
      山越美季・堀内宏明・奥津哲夫
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] タンパク質結晶化における金ナノ粒子と銀ナノ粒子の表面プラズモン共鳴の効果の比較2018

    • Author(s)
      伊藤 明日香・堀内 宏明・奥津 哲夫
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 増強電場による分子の整列とダイマー形成反応を併用したタンパク質の結晶化の試み2018

    • Author(s)
      大塚玲美奈・堀内宏明・奥津哲夫
    • Organizer
      日本化学会第98回春季年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 光線力学療法への応用を目指したpH応答性ポルフィリン誘導体の開発2017

    • Author(s)
      堀内 宏明・平原 阿槻・栗原 亮太・奥津 哲夫
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2017-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 光線力学療法に用いるpH応答性ポルフィリンの最適化2017

    • Author(s)
      堀内 宏明・平原 阿槻・奥津 哲夫
    • Organizer
      日本化学会第 97 春季年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] The Study of pH-Responsive Photosensitizer for Improving Water Solubility2017

    • Author(s)
      Masataka Isogai, Hiroaki Horiuchi, Kazuki Hirakawa, Tetsuo Okutsu
    • Organizer
      日本化学会第 97 春季年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] The activatable photosensitizer using irreversible sonochemical reaction2017

    • Author(s)
      Takeru Mashimo, Hiroaki Horiuchi, Tetsuo Okutsu
    • Organizer
      日本化学会第 97 春季年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Protein crystallization induced by surface plasmonic resonance in International Space Station "KIBO"2017

    • Author(s)
      Shuuhei Kasahara, Hiroaki Horiuchi, Tetsuo Okutsu
    • Organizer
      日本化学会第 97 春季年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 光線力学療法への応用を志向したpH応答性光増感剤の開発2017

    • Author(s)
      堀内 宏明・磯貝 将孝・平原阿槻・平川和貴・奥津哲夫
    • Organizer
      2017光化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] PDTにおける光副作用の抑制を目指したpH応答性リン(Ⅴ)ポルフィリンの研究2017

    • Author(s)
      磯貝 将孝・堀内宏明・平川和貴・奥津哲夫
    • Organizer
      2017光化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] タンパク質のアミノ酸の組成および立体構造の特徴と励起状態の性質の関連2017

    • Author(s)
      横山大・堀内宏明・奥津哲夫
    • Organizer
      2017光化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] pH応答性光増感剤の分子内直交性が一重項酸素生成のON/OFFスイッチングに及ぼす影響2017

    • Author(s)
      浜野美咲・堀内宏明・平原阿槻・栗原亮太・奥津哲夫
    • Organizer
      2017光化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 超音波を用いた光増感剤会合体の活性制御に及ぼす分子間相互作用の影響2017

    • Author(s)
      星野涼・堀内宏明・樋口みなみ・狩野貴行・奥津哲夫
    • Organizer
      2017光化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of water soluble pH-Activatable Photosensitizing Drug for Photodynamic Therapy2017

    • Author(s)
      H. Horiuchi, M. Isogai, K. Hirakawa, S. Torii, T. Okutsu
    • Organizer
      GUMI 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光免疫療法への応用を目指した糖鎖連結光増感剤の開発2017

    • Author(s)
      久保田諒・石井希実・佐野加苗・奥津哲夫・松尾一郎・堀内宏明
    • Organizer
      東北糖鎖研究会・東京糖鎖研究会合同シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 光線力学療法の副作用低減を目指したpH応答性ポルフィリン誘導体の開発2017

    • Author(s)
      堀内宏明・ 平原阿槻・ 磯貝将孝・平川和貴・ 奥津哲夫
    • Organizer
      フォトダイナミックセラノスティクス研究会
    • Place of Presentation
      静岡県浜松市
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] pH-Activatable Photosensitizing Drug for Photodynamic Therapy of Cancer2017

    • Author(s)
      H. Horiuchi, A. Hirabara, M. Isogai, S. Torii, T. Okutsu
    • Organizer
      GUMI 2016
    • Place of Presentation
      Kiryu, Gunma
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 酸応答性光増感剤に及ぼすアミノ置換基の効果2016

    • Author(s)
      平原阿槻・堀内宏明・栗原亮太・奥津哲夫
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Photochemically induced crystallization of protein in Internatiomnal Space Station "KIBO"2016

    • Author(s)
      KASAHARA. Shuuhei, AMANO. Yukiko, HORIUCHI. Hiroaki, OKUTSU. Tetsuo
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] リゾチームの光化学反応の初期過程2016

    • Author(s)
      奥成歩・堀内宏明・奥津哲夫
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] タンパク質の光誘起結晶化におけるテンプレート分子2016

    • Author(s)
      奥津 哲夫・中村 清明・横山 大・堀内 宏明
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京都目黒区
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ON/OFFスイッチング型の光増感剤の開発2016

    • Author(s)
      堀内宏明・栗原亮太・平原阿槻・奥津哲夫
    • Organizer
      第26回 日本光線力学学会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2016 Research-status Report
  • [Presentation] ON/OFFスイッチング型の光増感剤の開発2016

    • Author(s)
      堀内宏明・栗原亮太・平原阿槻・奥津哲夫
    • Organizer
      フォトダイナミックセラノスティクスのためのポルフィリン研究会
    • Place of Presentation
      群馬県草津町
    • Related Report
      2016 Research-status Report
  • [Book] Spectroscopic Tools for the Diagnosis and Treatment of Cancer ーA Symposium Bookin PACIFICHEM 20152017

    • Author(s)
      Editor Norio Miyoshi, Kazutaka Hirakawa, Sukalyan Kumar Kundu (分担:Chapter 7: Hiroaki Horiuchi)
    • Total Pages
      174
    • Publisher
      Sankeisha
    • ISBN
      9784864877039
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi