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Area identification and neuronal circuit analysis for non-motor function of the cerebellum

Research Project

Project/Area Number 16K07025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Sugihara Izumi  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60187656)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsげっ歯類 / 橋核 / 小脳 / 非運動機能 / 第I脚 / 軸索投射 / プルキンエ細胞 / Pcdh10 / 霊長類 / マーモセット / 核磁気共鳴画像(MRI) / 解剖学 / 神経科学 / 脳・神経 / マウス
Outline of Final Research Achievements

We showed that crus I in the rodent cerebellum is homologous with the combination of crus I and crus II in the human and primate cerebellums, which are involved in non-motor function, by morphological analysis, neural projection analysis, and molecular expression analysis. This result enables studies on non-motor functions such as cognitive function accurately in the rodent cerebellum. We also showed that crus I in rodents receives innervation of the rostral part of the pontine nucleus, as the basis of its involvement in non-motor functions, has a strong expression of protocadherin 10, and shift laterally during embryonic development, indicating peculiarities of this area in the cerebellum.

Academic Significance and Societal Importance of the Research Achievements

小脳は、運動制御機能に関与するが、近年、非運動機能にもかかわることが明らかにされ、小脳に原因のある自閉症や高次機能障害も注目されている。小脳に機能区分が存在するので、小脳非運動機能の実験や解析を齧歯類モデルで行う場合、ヒトでの非運動機能領域に相当する場所を正しく同定した上で行う必要がある。本研究においては、齧歯類の小脳において、非運動機能領域を小脳の第I脚に同定し、さらに、そこがいかなる特徴を持つ領域なのかを軸索投射、分子発現および形成過程の点から解析して、小脳非運動機能の基盤を明らかにした。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (38 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Heterogeneous vestibulocerebellar mossy fiber projections revealed by single axon reconstruction in the mouse2020

    • Author(s)
      Ando Takahiro、Ueda Mitsuhito、Luo Yuanjun、Sugihara Izumi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 528 Issue: 10 Pages: 1775-1802

    • DOI

      10.1002/cne.24853

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dense projection of Stilling’s nucleus spinocerebellar axons that convey tail proprioception to the midline area in lobule VIII of the mouse cerebellum.2020

    • Author(s)
      Luo Y, Onozato T, Wu X, Sasamura K, Sakimura K, Sugihara I
    • Journal Title

      Brain Structure and Function

      Volume: 225 Issue: 2 Pages: 621-638

    • DOI

      10.1007/s00429-020-02025-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Divergent projections of single pontocerebellar axons to multiple cerebellar lobules in the mouse2019

    • Author(s)
      Biswas Mohammad Shahangir、Luo Yuanjun、Sarpong Gideon Anokye、Sugihara Izumi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 527 Issue: 12 Pages: 1966-1985

    • DOI

      10.1002/cne.24662

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The entire trajectories of single pontocerebellar axons and their lobular and longitudinal terminal distribution patterns in multiple aldolase C‐positive compartments of the rat cerebellar cortex2019

    • Author(s)
      Na Jie、Sugihara Izumi、Shinoda Yoshikazu
    • Journal Title

      Journal of Comparative Neurology

      Volume: 527 Issue: 15 Pages: 2488-2511

    • DOI

      10.1002/cne.24685

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reorganization of longitudinal compartments in the laterally protruding paraflocculus of the postnatal mouse cerebellum.2019

    • Author(s)
      Panezai SK, Luo Y, Vibulyaseck S, Sarpong GA, Nguyen-Minh VT, Nedelescu H, Hirano S, Sugihara I.
    • Journal Title

      J Comp Neurol.

      Volume: 1 Issue: 10 Pages: 1-10

    • DOI

      10.1002/cne.24849

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 登上線維が作る小脳のマイクロゾーン.2019

    • Author(s)
      杉原 泉
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 928-931

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice2019

    • Author(s)
      Nguyen-Minh Viet T.、Tran-Anh Khoa、Luo Yuanjun、Sugihara Izumi
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 12

    • DOI

      10.3389/fncel.2018.00513

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebellar modules in the olivo-cortico-nuclear loop demarcated by pcdh10 expression in the adult mouse2018

    • Author(s)
      Sarpong Gideon A.、Vibulyaseck Suteera、Luo Yuanjun、Biswas Mohammad S.、Fujita Hirofumi、Hirano Shinji、Sugihara Izumi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 526 Issue: 15 Pages: 2406-2427

    • DOI

      10.1002/cne.24499

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Single axonal morphology and termination to cerebellar aldolase C stripes characterize distinct spinocerebellar projection systems originating from the thoracic spinal cord in the mouse2017

    • Author(s)
      Luo Yuanjun、Patel Radhika Pooja、Sarpong Gideon Anokye、Sasamura Kazuma、Sugihara Izumi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 526 Issue: 4 Pages: 681-706

    • DOI

      10.1002/cne.24360

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations2017

    • Author(s)
      Tang Tianyu、Xiao Jianqiang、Suh Colleen Y.、Burroughs Amelia、Cerminara Nadia L.、Jia Linjia、Marshall Sarah P.、Wise Andrew K.、Apps Richard、Sugihara Izumi、Lang Eric J.
    • Journal Title

      The Journal of Physiology

      Volume: 595 Issue: 15 Pages: 5341-5357

    • DOI

      10.1113/jp274252

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum2017

    • Author(s)
      Vibulyaseck Suteera、Fujita Hirofumi、Luo Yuanjun、Tran Anh Khoa、Oh-Nishi Arata、Ono Yuichi、Hirano Shinji、Sugihara Izumi
    • Journal Title

      Journal of Comparative Neurology

      Volume: 525 Issue: 14 Pages: 2971-2990

    • DOI

      10.1002/cne.24250

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crus I in the Rodent Cerebellum: Its Homology to Crus I and II in the Primate Cerebellum and Its Anatomical Uniqueness Among Neighboring Lobules2017

    • Author(s)
      Sugihara Izumi
    • Journal Title

      The Cerebellum

      Volume: 17 Issue: 1 Pages: 49-55

    • DOI

      10.1007/s12311-017-0911-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lobular homology in cerebellum hemispheres of humans, non-human primates and rodents: a structural, axonal tracing and molecular expression analysis.2017

    • Author(s)
      Luo Y, Fujita H, Nedelescu H, Biswas MS, Sato C, Ying S, Takahashi M, Akita K, Higashi T, Aoki I, Sugihara I.
    • Journal Title

      Brain Structure and Function

      Volume: 印刷中 Issue: 6 Pages: 2449-2472

    • DOI

      10.1007/s00429-017-1436-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Purkinje cell intrinsic excitability and plasticity linked with longitudinal compartmentalization in the mouse cerebellar cortex.2020

    • Author(s)
      Viet T Nguyen-Minh, Khoa Tran-Anh, Izumi Sugihara
    • Organizer
      CBIR 若手インスパイアシンポジウム.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Organization of longitudinal compartments in the developing paraflocculus of the postnatal mouse cerebellum.2020

    • Author(s)
      Saddam K. Panezai, Yuanjun Luo, Viet T. Nguyen-Minh, Izumi Sugihara
    • Organizer
      CBIR 若手インスパイアシンポジウム.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Purkinje cell compartmentalization in the embryonic mouse cerebellum, analysis with birthday-specific neuronal labeling.2019

    • Author(s)
      Khoa Tran-Anh, Tatsumi Hirata, Viet Nguyen-Minh, Izumi Sugihara
    • Organizer
      42th Annual Meeting of Japanese Neuroscience Society (Neuroscience 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purkinje cell intrinsic excitability and plasticity linked with longitudinal compartmentalization in the mouse cerebellar cortex.2019

    • Author(s)
      Viet T Nguyen-Minh, Khoa Tran-Anh, Izumi Sugihara.
    • Organizer
      42th Annual Meeting of Japanese Neuroscience Society (Neuroscience 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single axon morphology of medial vestibular nucleus neurons that project to the cerebellum.2019

    • Author(s)
      Takahiro Ando, Izumi Sugihara
    • Organizer
      42th Annual Meeting of Japanese Neuroscience Society (Neuroscience 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 単一前庭神経核細胞における小脳への軸索投射様式の解析2019

    • Author(s)
      安藤 貴弘、杉原 泉
    • Organizer
      めまい平衡学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The lobular and striped organization of the cerebellar hemisphere in relation to projection patterns of afferent and efferent axons in rodents, with a special focus on crus I.2018

    • Author(s)
      Sugihara I, Biswas MS, Sarpong GA, Luo Y
    • Organizer
      The 75th Fujihara Seminar ‘cerebellum as a CNS hub’, Tokyo Medical and Dental University, Tokyo, Japan. Deceber 1-4, 2018, December 3. Tokyo
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Single axon morphology revealed distinct groups of spinocerebellar projections.2018

    • Author(s)
      Luo Y, Sugihara I.
    • Organizer
      第10回CBIR/ONSA/大学院セミナー共催若手インスパイアシンポジウム2018年2月13日東京医科歯科大学
    • Related Report
      2017 Research-status Report
  • [Presentation] The ansiform lobule (crus I in the rodent cerebellum) is unique in its conformation, axonal connection, striped pattern, evolution and development in the mammalian cerebellum.2017

    • Author(s)
      Sugihara I.
    • Organizer
      The 8th International Symposium of the Society for Research on the Cerebellum and Ataxias (SRCA): from Development to Disease
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Historical inconsistency in definitions of cerebellar hemispheric lobules (crus I and crus II of the ansiform lobule) of non-human primates.2017

    • Author(s)
      Sugihara I, Luo Y, Fujita H.
    • Organizer
      Neuroscience 2018, November 3-7 in San Diego, CA.
    • Related Report
      2017 Research-status Report
  • [Presentation] Single axon morphology of the spinocerebellar projection in the mouse.2017

    • Author(s)
      Sugihara I, Luo Y.
    • Organizer
      Neuroscience 2018, November 3-7 in San Diego, CA.
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of compartments in the cerebellar nuclei and inferior olive based on molecular expression patterns and topography of Purkinje cell axonal projections.2017

    • Author(s)
      Gideon A Sarpong GA, Fujita H, Vibulyaseck S, Hirano S, Sugihara I.
    • Organizer
      40th Annual Meating of Japanese Neuroscience Society, Yokohama International Conference Hall.
    • Related Report
      2017 Research-status Report
  • [Presentation] Separation and migration of Purkinje cell subsets observed in the OL-KO mouse embryonic cerebellar cortex.2017

    • Author(s)
      Viboonyasek S, Fujita H, Luo Y, Ono Y, Hirano S, Sugihara I.
    • Organizer
      40th Annual Meating of Japanese Neuroscience Society, Yokohama International Conference Hall.
    • Related Report
      2017 Research-status Report
  • [Presentation] Morphology of single pontocerebellar axons reconstructed in the mouse cerebellum.2017

    • Author(s)
      Biswas MS, Luo Y, Sugihara I.
    • Organizer
      40th Annual Meating of Japanese Neuroscience Society, Yokohama International Conference Hall.
    • Related Report
      2017 Research-status Report
  • [Presentation] Morphology of single spinocerebellar axons in the mouse.2017

    • Author(s)
      Luo Y, Sugihara I.
    • Organizer
      40th Annual Meating of Japanese Neuroscience Society, Yokohama International Conference Hall.
    • Related Report
      2017 Research-status Report
  • [Presentation] Early development of the longitudinal striped compartments in the prenatal mouse cerebellum studied with three-dimensional mapping of Protocadherin 10 expression2016

    • Author(s)
      Vibulyaseck S, Sarpong GA, Fujita H, Hirano S, Sugihara I
    • Organizer
      Neuroscience 2016, The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama , Yokohama
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of the cerebellar lobules that are homologous to human crus I/II in macaque, marmoset, rat and mouse2016

    • Author(s)
      Luo Y, Fujita H, Hermina N, Sato C, Ying S, Takahashi M, Biswas MS, Akita K, Aoki I, Sugihara I
    • Organizer
      Neuroscience 2016, The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama , Yokohama
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparison of expression patterns of different marker molecules of the cerebellar longitudinal striped compartments in the mouse2016

    • Author(s)
      Sarpong GA, Fujita H, Vibulyaseck S, Furuichi T, Hirano S, Sugihara I
    • Organizer
      Neuroscience 2016, The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama , Yokohama
    • Related Report
      2016 Research-status Report
  • [Book] The Olivocerebellar Tract. in: Gruol DL. Et al. Ed Essentials of Cerebellum and Cerebellar Disorders. A Primer For Graduate Students.2016

    • Author(s)
      Luo Y, Sugihara I
    • Total Pages
      7
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Remarks] 東京医科歯科大学大学院医歯学総合研究科 システム神経生理学分野

    • URL

      http://www.tmd.ac.jp/med/phy1/phy1.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2016 Research-status Report
  • [Remarks] TMDU, Department of Systems Neurophysiology

    • URL

      http://www.tmd.ac.jp/med/eng/eng/phy1-E.html

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Remarks] 東京医科歯科大学 システム神経生理学分野

    • URL

      http://www.tmd.ac.jp/med/phy1/phy1.html

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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