Establishment of a novel treatment with ivermectin targeting the Hippo pathway to gastric cancer.

• Project/Area Number: 16K07177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Kyushu University
• Principal Investigator: Eguchi Hidetoshi 九州大学, 大学病院, 講師 (90527756)
• Co-Investigator(Renkei-kenkyūsha): MIMORI KOSHI
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 胃癌 / Hippo経路 / YAP1 / イベルメクチン / リポジショニングドラッグ / 数理統計解析 / 膵癌 / 胃癌腹膜播種

Outline of Final Research Achievements

We aimed to clarify whether ivermectin, an antiparasitic drug, had antitumor effects on gastric cancer (GC) through inhibition of YAP1. In GC cell xenografts, ivermectin suppressed tumor growth.we explored the mechanism through which ivermectin regulated YAP1 expression. Ivermectin inhibited YAP1 nuclear expression and the downstream gene CTGF expression in GC cells. Ivermectin decreased YAP1 mRNA expression, thereby inhibiting nuclear accumulation of YAP1 in MKN1 cells. In survival analysis, low YAP1 mRNA expression was associated with a better prognosis in three independent GC datasets.

Academic Significance and Societal Importance of the Research Achievements

スキルス胃癌は比極めて予後の悪い腫瘍であり、腹膜播種の機序については未知な部分が多く、有効な治療法の確立が待たれる。我々はイベルメクチンがHippo経路の転写因子であるYAP1の 阻害効果を有することを見出し、 同薬剤投与により腹膜播種の抑制効果が期待される。またイベルメクチンはリポジショニングドラッグとしても有用性が期待される。

Research Products

• [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis (2019)
  • Author(s): Muto Yoshiharu*、Moroishi Toshiro*、Ichihara Kazuya、Nishiyama Masaaki、Shimizu Hideyuki、Eguchi Hidetoshi、Moriya Kyoji、Koike Kazuhiko、Mimori Koshi、Mori Masaki、Katayama Yuta、Nakayama Keiichi I. (*Equal contribution)
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Issue: 4 Pages: 950-965
  • DOI: 10.1084/jem.20180900
  • Peer Reviewed / Open Access
• [Journal Article] A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. (2019)
  • Author(s): Hayashi N, Kuroda Y, Saito T, Tsuruda Y, Niida A, Otsu H, Eguchi H, Masuda T, Suzuki Y, Natsugoe S, Mimori K.
  • Journal Title: Surg Today. Volume: Epub Issue: 9 Pages: 738-747
  • DOI: 10.1007/s00595-019-01789-7
  • Peer Reviewed / Open Access
• [Journal Article] Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer. (2019)
  • Author(s): Kurashige J, Yokobori T, Mima K, Sawada G, Takahashi Y, Ueo H, Takano Y, Matsumura T, Uchi R, Eguchi H, Sudo T, Sugimachi K, Mori M, Baba H, Mimori K.
  • Journal Title: Oncol Lett Volume: 17(2) Pages: 2393-2399
  • DOI: 10.3892/ol.2018.9819
  • Peer Reviewed / Open Access
• [Journal Article] CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. (2019)
  • Author(s): Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 39(1) Issue: 1 Pages: 99-106
  • DOI: 10.21873/anticanres.13084
  • Peer Reviewed / Open Access
• [Journal Article] Multiregion Genomic Analysis of Serially Transplanted Patient-derived Xenograft Tumors. (2019)
  • Author(s): Sato K, Niida A, Masuda T, Shimizu D, Tobo T, Kuroda Y, Eguchi H, Nakagawa T, Suzuki Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 16(1) Issue: 1 Pages: 21-27
  • DOI: 10.21873/cgp.20109
  • Peer Reviewed / Open Access
• [Journal Article] Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular Carcinoma (HCC). (2018)
  • Author(s): Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Anticancer Res Volume: 38(12) Issue: 12 Pages: 6631-6638
  • DOI: 10.21873/anticanres.13030
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients (2018)
  • Author(s): Shuhei Ito et al
  • Journal Title: Ann Surg Oncol Volume: 25 Issue: 12 Pages: 3755
  • DOI: 10.1245/s10434-018-6739-4
  • URL: https://pure.teikyo.jp/en/publications/66518d93-39f2-4080-a050-1e22477a4458
  • Peer Reviewed / Open Access
• [Journal Article] Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy. (2018)
  • Author(s): Sugimachi K, Sakimura S, Kuramitsu S, Hirata H, Niida A, Iguchi T, Eguchi H, Masuda T, Morita M, Toh Y, Maehara Y, Suzuki Y, Mimori K.
  • Journal Title: Br J Cancer. Volume: 4 Issue: 4 Pages: 419-423
  • DOI: 10.1038/s41416-018-0208-5
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. (2018)
  • Author(s): Masuda T, Shinden Y, Noda M, Ueo H, Hu Q, Yoshikawa Y, Tsuruda Y, Kuroda Y, Ito S, Eguchi H, Ohno S, Mimori K.
  • Journal Title: Anticancer Res. Volume: 38(8) Issue: 8 Pages: 4515-4523
  • DOI: 10.21873/anticanres.12755
  • Peer Reviewed / Open Access
• [Journal Article] A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer (2018)
  • Author(s): Saito T, Niida A, Uchi R, Hirata H, Kodama M, Okimoto T, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K, et al.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2884-2884
  • DOI: 10.1038/s41467-018-05226-0
  • NAID: 120006551763
  • Peer Reviewed / Open Access
• [Journal Article] Over expression of FGFR1 Promotes Peritoneal Dissemination Via Epithelial-to-Mesenchymal Transition in Gastric Cancer. (2018)
  • Author(s): Shimizu D, Saito T, Ito S, Masuda T, Kurashige J, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 15(4) Issue: 4 Pages: 313-320
  • DOI: 10.21873/cgp.20089
  • Peer Reviewed / Open Access
• [Journal Article] Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. (2018)
  • Author(s): Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K
  • Journal Title: Oncology Volume: 3 Issue: 3 Pages: 179-187
  • DOI: 10.1159/000488860
  • Peer Reviewed / Open Access
• [Journal Article] Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer. (2018)
  • Author(s): Hu Q, Masuda T, Sato K, Tobo T, Nambara S, Kidogami S, Hayashi N, Kuroda Y, Ito S, Eguchi H, Saeki H, Oki E, Maehara Y, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 25(3) Issue: 3 Pages: 745-753
  • DOI: 10.1245/s10434-017-6292-6
  • Peer Reviewed / Open Access
• [Journal Article] Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. (2017)
  • Author(s): Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K
  • Journal Title: Oncotarget. Volume: 8(64) Issue: 64 Pages: 107666-107677
  • DOI: 10.18632/oncotarget.22587
  • NAID: 120006454566
  • Peer Reviewed / Open Access
• [Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer (2017)
  • Author(s): Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
  • Journal Title: Oncotarget Volume: 8(45) Issue: 45 Pages: 78598-78613
  • DOI: 10.18632/oncotarget.20009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs as Biomarkers in Colorectal Cancer. (2017)
  • Author(s): Masuda T, Hayashi N, Kuroda Y, Ito S, Eguchi H, Mimori K
  • Journal Title: Cancers (Basel). Volume: 9(9) Issue: 9 Pages: 124-124
  • DOI: 10.3390/cancers9090124
  • Peer Reviewed / Open Access
• [Journal Article] Up-regulation of SLC9A9 Promotes Cancer Progression and Is Involved in Poor Prognosis in Colorectal Cancer. (2017)
  • Author(s): Ueda M, Iguchi T, Masuda T, Komatsu H, Nambara S, Sakimura S, Hirata H, Uchi R, Eguchi H, Ito S, Sugimachi K, Mizushima T, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res. Volume: 37(5) Pages: 2255-2263
  • Peer Reviewed
• [Journal Article] The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma (2017)
  • Author(s): Shibamoto M, Hirata H, Eguchi H, Sawada G, Sakai N, Kajiyama Y, Mimori K
  • Journal Title: Oncology Letters Volume: 13 Issue: 3 Pages: 1761-6
  • DOI: 10.3892/ol.2017.5646
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma. (2017)
  • Author(s): Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
  • Journal Title: ONCOLOGY Volume: - Issue: 1 Pages: 67-74
  • DOI: 10.1159/000463390
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma. (2017)
  • Author(s): Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K
  • Journal Title: Anticancer Res. Volume: 37(3) Pages: 1083-1090
  • Peer Reviewed
• [Journal Article] Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 24(3) Issue: 3 Pages: 850-859
  • DOI: 10.1245/s10434-016-5573-9
  • Peer Reviewed / Open Access
• [Journal Article] miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. (2016)
  • Author(s): Iguchi T, Nambara S, Masuda T, Komatsu H, Ueda M, Kidogami S, Ogawa Y, Hu Q, Sato K, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: PLoS One. Volume: 11(11) Issue: 11 Pages: e0165912-e0165912
  • DOI: 10.1371/journal.pone.0165912
  • Peer Reviewed / Open Access
• [Journal Article] Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence (2016)
  • Author(s): Ueda M, Iguchi T, Masuda T, Nakahara Y, Hirata H, Uchi R, Niida A, Momose K, Sakimura S, Chiba K, Eguchi H, Ito S, Sugimachi K, Yamasaki M, Suzuki Y, Miyano S, Doki Y, Mori M, Mimori K
  • Journal Title: Oncotarget Volume: 7(38) Issue: 38 Pages: 62280-62291
  • DOI: 10.18632/oncotarget.11409
  • Peer Reviewed / Open Access
• [Journal Article] 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis (2016)
  • Author(s): Sugimachi K, Yamaguchi R, Eguchi H, Ueda M, Niida A, Sakimura S, Hirata H, Uchi R, Shinden Y, Iguchi T, Morita K, Yamamoto K, Miyano S, Mori M, Maehara Y, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 23(Suppl 4) Issue: S4 Pages: 546-551
  • DOI: 10.1245/s10434-016-5374-1
  • Peer Reviewed / Open Access
• [Journal Article] HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Ueda M, Kidogami S, Ogawa Y, Nambara S, Sato K, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(6) Pages: 2767-73
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer. (2016)
  • Author(s): Sugimachi K, Matsumura T, Shimamura T, Hirata H, Uchi R, Ueda M, Sakimura S, Iguchi T, Eguchi H, Masuda T, Morita K, Takenaka K, Maehara Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 23(12) Issue: 12 Pages: 3948-3955
  • DOI: 10.1245/s10434-016-5289-x
  • Peer Reviewed / Open Access
• [Journal Article] Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma. (2016)
  • Author(s): Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Cancer Res. Volume: 76(11) Issue: 11 Pages: 3265-76
  • DOI: 10.1158/0008-5472.can-15-2601
  • Peer Reviewed / Open Access
• [Journal Article] Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma. (2016)
  • Author(s): Iguchi T, Komatsu H, Masuda T, Nambara S, Kidogami S, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(5) Pages: 2139-44
  • Peer Reviewed / Open Access
• [Journal Article] Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination. (2016)
  • Author(s): Kurashige J, Hasegawa T, Niida A, Sugimachi K, Deng N, Mima K, Uchi R, Sawada G, Takahashi Y, Eguchi H, Inomata M, Kitano S, Fukagawa T, Sasako M, Sasaki H, Sasaki S, Mori M, Yanagihara K, Baba H, Miyano S, Tan P, Mimori K.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 22371-22371
  • DOI: 10.1038/srep22371
  • NAID: 120006352400
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and biological significance of circulating tumor cells in cancer. (2016)
  • Author(s): Masuda T, Hayashi N, Iguchi T, Ito S, Eguchi H, Mimori K.
  • Journal Title: Mol Oncol. Volume: 10 Issue: 3 Pages: 408-17
  • DOI: 10.1016/j.molonc.2016.01.010
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Ueda M, Nambara S, Saito T, Hirata H, Sakimura S1, Takano Y1, Uchi R1, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Oncol Rep Volume: 35 Issue: 4 Pages: 2073-80
  • DOI: 10.3892/or.2016.4593
  • Peer Reviewed / Open Access
• [Presentation] 陥凹型早期大腸癌の遺伝子学的特徴 (2018)
  • Author(s): 江口英利、北川彰洋、倉光正太郎、清水大、藤井昌志、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 新規癌遺伝子oxysterol binding protein like 3(OSBPL3)はR-Ras/Akt活性化を介して胃癌の増殖を促進する (2018)
  • Author(s): 胡慶江、増田隆明、北川彰洋、倉光正太郎、清水大、吉川幸宏、野田美和、鶴田祐介、黒田陽介、伊藤修平、江口英利、前原喜彦、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 胃癌患者の術前末梢血、骨髄血における癌関連遺伝子、免疫関連遺伝子発現の臨床的意義 (2018)
  • Author(s): 伊藤修平、深川剛生、佐藤哲也、北川彰洋、藤井昌志、倉光正太郎、清水大、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、江口英利、笹子三津留、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Autitumor effects of the antiparasitic agent ivermectin via inhibition of yes-associated protein 1 expression in gastric cancer (2018)
  • Author(s): S Kuramitsu, S Nambara, Q Hu, Y Kuroda, T Masuda, S Ito, H Eguchi, Y Maehara, K Mimori.
  • Organizer: AACR Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] 陥凹型早期大腸癌における網羅的遺伝子解析の検討 (2018)
  • Author(s): 江口英利、清水大、倉光正太郎、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] Immune related genes expression in peripheral blood in patients with gastric cancer. (2018)
  • Author(s): Shuhei Ito,Takeo Fukagawa, Dai Shimizu, Qingjian Hu, Yousuke Kuroda, Takaaki Masuda, Hidetoshi Eguchi, Hitoshi Katai, Mitsuru Sasako, Koshi Mimori
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 大腸癌におけるoxysterol binding protein like 3(OSBPL3)の臨床的意義 (2018)
  • Author(s): 江口英利、胡慶江、増田隆明、清水大、藤井昌志、野田美和、神山勇太、吉川幸宏、脇山浩明、佐藤晋彰、鶴田祐介、黒田陽介、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 胃癌における血中pre-miR-488の予後予測因子としての有用性 (2018)
  • Author(s): 鶴田祐介、増田隆明、野田美和、倉光正太郎、脇山浩明、清水大、吉川幸宏、大津甫、黒田陽介、江口英利、夏越祥次、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 抗寄生虫薬イベルメクチンのYAP1阻害を介した胃癌における抗腫瘍効果 (2018)
  • Author(s): 大津甫、南原翔、増田隆明、鶴田祐介、倉光正太郎、野田美和、脇山浩明、吉川幸宏、佐藤晋彰、黒田陽介、江口英利、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 腹膜播種関連遺伝子としてのSpondin2の同定とその臨床的・生物学的意義 (2018)
  • Author(s): 倉光正太郎、増田隆明、胡慶江、鶴田祐介、大津甫、黒田陽介、江口英利、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 胃癌切除標本のPD-1、PD-L1、CD8遺伝子発現に着目した予後予測マーカーの同定 (2018)
  • Author(s): 伊藤修平、増田隆明、野田美和、清水大、脇山浩明、吉川幸宏、胡慶江、佐藤晋彰、齋藤衆子、鶴田祐介、黒田陽介、江口英利、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 肝細胞癌における糖代謝関連遺伝子FBP1の発現の意義 (2017)
  • Author(s): 江口英利、杉町圭史、平田秀成、野田美和、吉川幸宏、木戸上真也、胡慶江、南原翔、林直樹、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] ARL4Cは胃癌患者の腹膜播種および予後不良の関与する (2017)
  • Author(s): 江口英利、胡慶江、吉川幸宏、木戸上真也、南原翔、林直樹、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第72回日本消化器外科学会
• [Presentation] 大腸癌における7番染色体上のドライバー遺伝子の同定. (2016)
  • Author(s): 江口英利、増田隆明、胡慶江、木戸上真也、南原翔、小松久晃、林直樹、井口友宏、伊藤修平、三森功士
  • Organizer: 第71回日本消化器外科学会
  • Place of Presentation: 徳島
  • Year and Date: 2016-07-20
• [Presentation] 大腸癌症例の原発巣および肝転移巣癌細胞の統合的解析による多様性の解明 (2016)
  • Author(s): 江口英利、高橋佑典,木戸上真也、胡慶江、南原翔、小松久晃、上田正射、林直樹、井口友宏、増田隆明、伊藤修平、三森功士
  • Organizer: 第116回日本外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-14