Investigation of immunotherapy targeting an epitope generated through autophagy.
| Project/Area Number |
16K07192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
DEMACHI-OKAMURA Ayako 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 主任研究員 (10546948)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | CTL / オートファジー / TCR / K-ras / 膵臓癌 / 腫瘍免疫 / 免疫療法 |
|---|
| Outline of Final Research Achievements |
To evaluate effect of cytotoxic T lymphocytes (CTLs) that respond pancreatic cancer, adoptively transferred CTLs in a mouse xenograft model. The CTL clones could work weakly, and the pancreatic cancer cells showed slower growth than control mice. Although little effects were demonstrated in this model, stronger effects needed to treat the pancreatic cancers. To overcome this point, clinical application of t-cell receptor (TCR) gene therapy was tested. As a results, good effects were observed in vitro analyses.
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| Academic Significance and Societal Importance of the Research Achievements |
ノーベル賞受賞をきっかけに広くがんに対する免疫チェックポイント阻害剤療法が注目されて、免疫細胞によるがん治療に期待が寄せられている。一部のがんには有効ではあるが。より広く有効性を得るためにはその標的となるがん抗原の詳細な情報が必要である。そこで、膵臓がんを標的とした免疫治療の可能性を検討すべく、T細胞療法の検討を行った。マウスにおける効果を確認し、より効果の高い治療であるT細胞受容体移入療法の可能性を検討して、高い効果が期待できる結果を得た。
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Report
(4 results)
Research Products
(5 results)
