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Investigation of immunotherapy targeting an epitope generated through autophagy.

Research Project

Project/Area Number 16K07192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

DEMACHI-OKAMURA Ayako  愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 主任研究員 (10546948)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsCTL / オートファジー / TCR / K-ras / 膵臓癌 / 腫瘍免疫 / 免疫療法
Outline of Final Research Achievements

To evaluate effect of cytotoxic T lymphocytes (CTLs) that respond pancreatic cancer, adoptively transferred CTLs in a mouse xenograft model. The CTL clones could work weakly, and the pancreatic cancer cells showed slower growth than control mice. Although little effects were demonstrated in this model, stronger effects needed to treat the pancreatic cancers. To overcome this point, clinical application of t-cell receptor (TCR) gene therapy was tested. As a results, good effects were observed in vitro analyses.

Academic Significance and Societal Importance of the Research Achievements

ノーベル賞受賞をきっかけに広くがんに対する免疫チェックポイント阻害剤療法が注目されて、免疫細胞によるがん治療に期待が寄せられている。一部のがんには有効ではあるが。より広く有効性を得るためにはその標的となるがん抗原の詳細な情報が必要である。そこで、膵臓がんを標的とした免疫治療の可能性を検討すべく、T細胞療法の検討を行った。マウスにおける効果を確認し、より効果の高い治療であるT細胞受容体移入療法の可能性を検討して、高い効果が期待できる結果を得た。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2017 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] Improving TCR affinity on 293T cells2019

    • Author(s)
      Ohta Rieko、Demachi-Okamura Ayako、Akatsuka Yoshiki、Fujiwara Hiroshi、Kuzushima Kiyotaka
    • Journal Title

      Journal of Immunological Methods

      Volume: 466 Pages: 1-8

    • DOI

      10.1016/j.jim.2018.11.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Frequent somatic alterations involving pro- grammed death ligands in EBV-related lymphomas2017

    • Author(s)
      片岡圭亮、三好寛明、岡村文子、坂田征士、Lucile Couronne、木暮泰寛、土橋映仁、佐藤康晴、西田賢司、白石友一、田中洋子、千葉健一、綿谷陽作、塩澤裕介、吉田健一、真田昌、加藤元博、葛島清隆、宮野悟、大田 泰徳、伊豆津宏二、吉野正、Olivier Hermine、竹内賢吾、赤塚美樹、大島孝一、小川誠司
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] がん細胞では異常なTAP分子によりエピトープを提示する2016

    • Author(s)
      岡村文子
    • Organizer
      第8回血液疾患免疫療法学会
    • Place of Presentation
      北海道大学学友会館フラテ(札幌市)
    • Related Report
      2016 Research-status Report
  • [Remarks] 愛知県がんセンター研究所 腫瘍免疫学部

    • URL

      http://www.pref.aichi.jp/cancer-center/ri/01bumon/05shuyo_meneki/index.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 愛知県がんセンター研究所腫瘍免疫学部ホームページ

    • URL

      https://www.pref.aichi.jp/cancer-center/ri/01bumon/05shuyo_meneki/index.html#member

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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