• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Bioinformatics analyses to search for ribosomal peptide biosynthetic genes from filamentous fungi

Research Project

Project/Area Number 16K07226
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field System genome science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

NAGANO Nozomi  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (70357648)

Research Collaborator UMEMURA Myco  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糸状菌 / ゲノム / 遺伝子 / リボソーム・ペプチド / バイオインフォマティクス / 酵素 / 二次代謝 / 微生物 / 生体分子
Outline of Final Research Achievements

623 fungus genome data, including 299 data of Ascomycota/Pezizomycotina, and 176 data of Basidiomycota/Agaricomycotina from Dikarya of fungi, which have been published by JGI Genome Portal of the DOE Joint Genome Institute(JGI), were analyzed to predict precursor gene candidates for ribosomal peptides (RiPs), and ustYa homologous genes.
In addition, functional analyses of the nearby genes (within 20,000 bp) of the predicted RiP precursor candidates were performed. Amino acid composition of the gene products of the RiP precursors, whose signal peptides were excluded, was also analyzed.
Furthermore, the web site for the results of the analyses was developed.

Academic Significance and Societal Importance of the Research Achievements

研究代表者らが見出した新規環状リボソーム・ペプチドも含め二次代謝物の多くは、微量にしか生成されないため、これまで同定されてこなかった可能性が高い。しかしながら、バイオインフォマティクス技術により菌類ゲノム解析を進め、機能未知遺伝子の役割を解析することにより、新しい菌類二次代謝物の網羅的な発見に至ると考えられる。また、我が国では、醤油・味噌等の食品産業により、カビやキノコの培養技術も高く、遺伝子工学により、微量の新規生理活性物質を大量に合成する技術の発展にもつながると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Ribosomal peptide biosynthetic pathways widely conserved in filamentous fungi2016

    • Author(s)
      Myco Umemura, Nozomi Nagano, Akira Yoshimi, Ying Ye, Keietsu Abe, Kazuo Shin-ya, Hideaki Oikawa, Masayuki Machida
    • Journal Title

      Proceedings of SIMB 2016

      Volume: ー

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Ribosomal peptide biosynthetic pathways widely conserved in filamentous fungi2016

    • Author(s)
      Myco Umemura, Nozomi Nagano, Akira Yoshimi, Ying Ye, Keietsu Abe, Kazuo Shin-ya, Hideaki Oikawa, Masayuki Machida
    • Organizer
      2016 SIMB Annual Meeting and Exhibition
    • Place of Presentation
      Sheraton New Orleans, New Orleans(米国)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2020-07-01  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi