| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Liver regeneration was examined in mouse livers, which had portal vein branch ligation to left and median liver lobes. While ligated lobes were degenerated, liver regeneration, including hepatocyte growth, was detectable in nonligated liver lobes. Liver progenitor cell proliferation was noted around portal vein branches of ligated and nonligated lobes. In portal vein branch ligation experiments with TNFR1-knockout mice, hepatocyte growth took place, but no liver progenitor cells remarkably proliferated. The data suggest that TNFa signaling plays an important role in progenitor proliferation during liver regeneration induced by portal vein branch ligation.
|
