Understanding the evolution of metazoan multicellularity by using the expanded premetazoan models
Project/Area Number |
16K07468
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Evolutionary biology
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Research Institution | Prefectural University of Hiroshima |
Principal Investigator |
Suga Hiroshi 県立広島大学, 生命環境学部, 准教授 (30734107)
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Research Collaborator |
Ruiz-Trillo Iñaki
Miller Todd
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | 多細胞性進化 / 単細胞ホロゾア / 多細胞性 / 進化 / 細胞接着 / 細胞連絡 / 多細胞 / 細胞間連絡 / ゲノム |
Outline of Final Research Achievements |
The molecular mechanism that enabled the evolution of animal multicellularity has yet to be uncovered. We established and expanded the repertoire of “unicellular holozoan”models, the closest unicellular relatives to animals, by sequencing their genomes and transcriptomes and by developing the means to analyze the functions of their "multicellular" genes.
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Academic Significance and Societal Importance of the Research Achievements |
生物の設計図であるゲノムが解読され(1次元)、その働きかたを示すトランスクリプトーム(2次元)が明らかとなるとともに、こうした情報を実際の生物の体の作られ方に当てはめて捉えよう(3次元)という動きが活発です。比較的最近盛んになってきた進化発生学(本研究もその一つです)では、それを時間軸に沿って拡張し(4次元)、生物の進化の仕組みを遺伝子レベルで解き明かそうとしています。本研究は、特に動物が多細胞体制を進化させた「多細胞化」というイベントに注目し、動物に最も近い親戚である単細胞ホロゾアと呼ばれる単細胞生物群の研究を通じて、生物進化の仕組みの一部を解き明かそうとするものです。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Unicellular Origin of the Animal MicroRNA Machinery2018
Author(s)
Br?te Jon、Neumann Ralf S.、Fromm Bastian、Haraldsen Arthur A.B.、Tarver James E.、Suga Hiroshi、Donoghue Philip C.J.、Peterson Kevin J.、Ruiz-Trillo I?aki、Grini Paul E.、Shalchian-Tabrizi Kamran
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Journal Title
Current Biology
Volume: 28
Issue: 20
Pages: 3288-3295.e5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis2017
Author(s)
Gentekaki, E., Curtis, B. A., Stairs, C., Klimes, V., Elias, M., Salas, D., Herman, E. K., Eme, L., Arias, M. C., Henrissat, B., Hilliou, F., Klute, M. J., Suga et al.
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Journal Title
PLoS Biology
Volume: 15
Issue: 9
Pages: e2003769-e2003769
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dynamics of genomic innovation in the unicellular ancestry of animals2017
Author(s)
Grau-Bove, X., Torruella, G., Donachie, S., Suga, H., Leonard, G., Richards, T. A., Ruiz-Trillo, I
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Possibility of RhoGDIβ as a molecular target for biomedical applications2016
Author(s)
Tatsuka, M., Fujiwara, M., Okamoto, M., Hori, M., Sugihara, Y., Jikihara, H., Nakaoji, K., Hamada, K., Suga, H., and Shimamoto, F.
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Journal Title
J Life Environ Sci
Volume: 8
Pages: 1-12
NAID
Related Report
Peer Reviewed
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[Journal Article] Radiation-induced RhoGDIβ cleavage leads to perturbation of cell polarity: a possible link to cancer spreading2016
Author(s)
Fujiwara, M., Okamoto, M., Hori, M., Suga, H., Jikihara, H., Sugihara, Y., Shimamoto, F., Mori, T., Nakaoji, K., Hamada, K., Ota, T., Wiedemuth, R., Temme, A., and Tatsuka, M.
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Journal Title
J Cell Physiol
Volume: 0
Issue: 11
Pages: 0-0
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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