Evolution of human-specific cell-cell communication in the brain of anatomically modern human
| Project/Area Number |
16K07535
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical anthropology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
颯田 葉子 総合研究大学院大学, 先導科学研究科, 教授 (20222010)
|
|---|
| Research Collaborator |
Varki Ajit
|
|---|
| Project Period (FY) |
2016-10-21 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ヒトの進化 / 精神機能 / 脳 / 人類進化 / 現生人類 / シアル酸 |
|---|
| Outline of Final Research Achievements |
It has been suggested that the human-specific cell-cell communication mediated by Siglec-11 in the brain contributed to the gain of higher mental activity in the human lineage. To gain insight into an adaptive evolution in mental activities of anatomically modern human, the evolution of molecules involved in this human-specific cell-cell communication was examined. As a result, it was found that adaptive evolution began to operate on the human-specific cell-cell communication in East Asian populations about twenty thousand years ago. It is considered that this adaptive evolution has been driven by psychosocial stress due to change of social and cultural environments. The human-specific cell-cell communication might be therefore involved in social and cultural progresses in East Asia.
|
| Academic Significance and Societal Importance of the Research Achievements |
これまで現生人類の社会や文化の変化・発展と遺伝子の進化との関係はよくわかっていなかった。本研究から得られた知見は、現生人類における社会や文化の変化・発展に、遺伝子レベルでの適応進化が関与していることをはじめて示すものとなる。そして、これまでは人文社会学的な視点で考えられてきた我々の社会・文化の変化・発展の基盤について、自然科学的な視点を新たに提供することで、社会や文化の学際的な理解への第一歩となり、現代の社会や文化の多様性の背景を知り、相互理解を深める糸口となると考えられる。
|
Report
(4 results)
Research Products
(15 results)
