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Study on physiological functions of kynurenine pathway in chicks

Research Project

Project/Area Number 16K07989
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionKyoto University

Principal Investigator

Tomonaga Shozo  京都大学, 農学研究科, 助教 (00552324)

Research Collaborator SHIRAISHI Jun-ichi  
MAKINO Ryosuke  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsキヌレニン / ニワトリ / 成長 / ストレス / メタボローム解析 / ガスクロマトグラフ質量分析計 / トリプトファン代謝物の網羅的分析 / ガスクロマトグラフ三連四重極型質量分析計 / キノリン酸 / ピコリン酸 / キヌレニン経路 / トリプトファン / ニワトリヒナ
Outline of Final Research Achievements

I investigated influences of stress and growth on metabolite levels in kynurenine pathway and other metabolic pathways in chicks by GC/MS metabolomic analysis. Heat stress increased levels of kynurenine pathway metabolites, kynureinne and quinolinic acid. Growth affected some interesting metabolites levels while changes of kynurenine pathway metabolites could not checked because the sensitivity of analytical method was not enough. Therefore, I established new analytical method to quantify various tryptophan metabolites including kynurenine pathway metabolites in chicks.

Academic Significance and Societal Importance of the Research Achievements

ニワトリにおいて、成長やストレスとキヌレニン経路の関係は不明な点が多かった。本研究から、これらの関係解明に向けて有用な基盤情報と分析系を得ることができた。これらを用いた更なる研究は、ニワトリにおける生産向上に係る生理機能の解明に向けて有用である。今後、関連する研究成果の蓄積から、食糧自給率の改善が望まれる我が国における鶏卵や鶏肉の生産に資することを目指す。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] ニワトリのふ化直後における血漿中の成長関連低分子代謝物質の探索2018

    • Author(s)
      塩田駿介、友永省三
    • Journal Title

      微量栄養素研究

      Volume: 35 Pages: 35-40

    • NAID

      40021764362

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of high ambient temperature on plasma metabolomic profiles in chicks2018

    • Author(s)
      Tomonaga S, Okuyama H, Tachibana T, Makino R
    • Journal Title

      Animal Science Journal

      Volume: 89 Issue: 2 Pages: 448-455

    • DOI

      10.1111/asj.12951

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ニワトリの成長に関与するふ化直後の低分子代謝物質の探索2018

    • Author(s)
      塩田駿介・友永省三
    • Organizer
      第12回メタボロームシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ニワトリヒナの成長に伴う低分子代謝物質濃度の変化2016

    • Author(s)
      松尾康平・岡田直樹・友永省三
    • Organizer
      第10回メタボロームシンポジウム
    • Place of Presentation
      鶴岡メタボロームキャンパス レクチャーホール
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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