Roles of virus-host interactions in influenza virus replication
| Project/Area Number |
16K08016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Watanabe Tokiko 東京大学, 医科学研究所, 特任准教授 (60557479)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インフルエンザウイルス / 宿主因子 / ヌクレオプロテイン |
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| Outline of Final Research Achievements |
Influenza viruses utilize host cellular functions to replicate in infected cells. In this study, we focused on influenza viral nucleoprotein (NP) and examined the role of host factors that interact with NP in virus replication. We found that CLUH, a host protein whose cellular function is not well established, plays a key role in the subnuclear transport of influenza viral ribonucleoprotein. We also identified NP-interacting host proteins whose suppression inhibited influenza virus replication. These results suggest that NP-interacting host proteins could serve as antiviral drug targets.
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| Academic Significance and Societal Importance of the Research Achievements |
インフルエンザに対する治療には、ノイラミニダーゼ（NA）阻害剤がよく使用されているが、インフルエンザウイルスの表面糖蛋白質であるNAは突然変異率が高く、そのため耐性ウイルスの出現が大きな問題となっている。本研究では、NPと相互作用する宿主蛋白質に着目し、それらの機能発現を抑制することによって、ウイルス増殖が阻害されることを示した。以上の結果から、NPと相互作用するこれらの宿主因子を標的とした新たな治療薬開発が期待される。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Network-Guided Discovery of Influenza Virus Replication Host Factors.2019
Author(s)
Ackerman EE, Kawakami E, Katoh M, Watanabe T, Watanabe S, Tomita Y, Lopes TJ, Matsuoka Y, Kitano H, Shoemaker JE, Kawaoka Y
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Selection of antigenically advanced variants of seasonal influenza viruses.2016
Author(s)
Li C, Hatta M, Burke DF, Ping J, Zhang Y, Ozawa M, Taft AS, Das SC, Hanson AP, Song J, Imai M, Wilker PR, Watanabe T, Watanabe S, Ito M, Iwatsuki-Horimoto K et al.
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Journal Title
Nat Microbiol
Volume: 23
Issue: 6
Pages: 16058-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Impact of aging on the pathogenesis of avian influenza A(H7N9) virus infection in non-human primates2017
Author(s)
Fukuyama S, Iwatsuki-Horimoto K, Shoemaker JE, Nakajima N, Kiso M, Tomita Y, Katsura H, Maemura T, Watanabe T, Sato Y, Suzuki T, Hasegawa H and Kawaoka Y.
Organizer
第65回日本ウイルス学会学術集会
Related Report
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