| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Influenza viruses utilize host cellular functions to replicate in infected cells. In this study, we focused on influenza viral nucleoprotein (NP) and examined the role of host factors that interact with NP in virus replication. We found that CLUH, a host protein whose cellular function is not well established, plays a key role in the subnuclear transport of influenza viral ribonucleoprotein. We also identified NP-interacting host proteins whose suppression inhibited influenza virus replication. These results suggest that NP-interacting host proteins could serve as antiviral drug targets.
|
