| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Therapeutic antibodies utilizes the specificity of one monoclonal antibody to recognize one antigen. The aim of the study is to establish a method to establish monoclonal antibodies that can treat all influenza A virus infections. To that end, several methods of immunizing mice, several fusion methods, and some screening methods to detect antibody-producing hybridomas were performed, and finally, monoclonal antibodies which recognize multiple HA subtypes were established. That is, we have found a suitable method for producing antibodies that recognize multiple HA subtypes of influenza A virus. This method can also be applied to establish antibodies for the treatment of other viral infections.
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