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The evaluation of novel examination of diagnosis of Disseminated intravascular coagulation (DIC) in dogs

Research Project

Project/Area Number 16K08054
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionKagoshima University

Principal Investigator

Iwanaga Tomoko  鹿児島大学, 共同獣医学部, 助教 (60713287)

Co-Investigator(Kenkyū-buntansha) 福島 隆治  東京農工大学, (連合)農学研究科(研究院), 教授 (10466922)
齋藤 靖生  鹿児島大学, 農水産獣医学域獣医学系, 助教 (10731581)
丸山 征郎  鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
高橋 雅  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (40750419)
三浦 直樹  鹿児島大学, 農水産獣医学域獣医学系, 教授 (80508036)
Project Period (FY) 2016-10-21 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血液凝固 / 血栓症 / 敗血症 / 播種性血管内凝固 / 全血血栓観測システム / 新規血液凝固検査 / T-TAS / 出血傾向 / DIC / 血液凝固検査 / 血栓形成観測システム / 獣医学
Outline of Final Research Achievements

According to the novel blood coagulation examination in dogs, we assessed the repeatability and the effect of anticoagulation drugs in vivo and in vitro using Total Thrombus formation Analysis System (T-TAS) for the healthy control dogs in the first year. Next, we assessed the risk of bleeding in the perioperative period. We compared with this bleeding risk and the phenomenon of bleeding using measurements of APTT, PT, and T-TAS. Additionally, we assessed the risk of Disseminated Intravascular Coagulation (DIC) of systemic inflammation diseases like pancreatitis using the marker of thrombosis. And we assessed platelet aggregation in cardiology patients.

Academic Significance and Societal Importance of the Research Achievements

健常犬に対する再現性、各血液凝固薬の効果判定では、2017年国際学会で発表し、論文投稿中である。今後は抗凝固薬の治療効果判定にT-TASを含めて評価できる可能性があると考えられる。
周術期の出血リスクでは、従来の検査で検出不可能なリスクをT-TASで評価し、平成29年度日本小動物獣医学会九州地区大会にて、学会長賞を受賞した。
各疾患での血液凝固異常に関して検討し、。各疾患におけるT-TASの特徴を検出した。また、他の血液凝固検査との相関を検討し、T-TASの特徴を示すことができた。これは2019年国際学会で発表し、国際誌へ掲載された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Int'l Joint Research] Cornell university/University of Georgia(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] コーネル大学/ジョージア大学(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing2019

    • Author(s)
      Yamada S, Hirao D, Miura N, Iwanaga T, Kawaguchi T, Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R
    • Journal Title

      Experimental Animals

      Volume: 68 Issue: 2 Pages: 137-146

    • DOI

      10.1538/expanim.18-0100

    • NAID

      130007642989

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of chronological changes in blood characteristics in the atrium and peripheral vessels after the development of non-valvular atrial fibrilation2018

    • Author(s)
      Yamada S,Hirao D, Miura N, Iwanaga T, Kawaguchi T,Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R
    • Journal Title

      Thrombosis Reserch

      Volume: 171 Pages: 31-37

    • DOI

      10.1016/j.thromres.2018.09.040

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] EVALUATION OF THE TOTAL-THROMBUS ANALYSIS SYSTEM (T-TAS) IN DOGS AT RISK OF BLEEDING2019

    • Author(s)
      Iwanaga T, Mura N, Brainard B, Brooks MB, Goggs R
    • Organizer
      25th International Veterinary Emergency & Critical Care Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全血血栓形成観測システム(Total Thrombus Formation System: T-TAS)の血栓性疾患の評価2018

    • Author(s)
      三浦直樹、岩永朋子、齋藤靖夫、高橋雅、福島隆治
    • Organizer
      日本小動物獣医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 知らなければ絶対に診断できない肺血栓塞栓症 その正体を血液検査から探る2018

    • Author(s)
      岩永朋子
    • Organizer
      日本小動物獣医学会卒後研修会
    • Related Report
      2018 Research-status Report
  • [Presentation] 外来症例の不整脈診断2017

    • Author(s)
      岩永朋子
    • Organizer
      第13回日本獣医内科学アカデミー学術大会
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] 「救急医療」;循環器疾患における救急医療2017

    • Author(s)
      岩永朋子
    • Organizer
      第13回鹿児島小動物臨床フォーラム
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] Novel Thrombogenicity Examination of Whoel Blood: Total Thronbus-formation Analysis System in Dogs2017

    • Author(s)
      Tomoko Iwanaga, Shusaku Yamada, Ryuji Fukushima, Tomoka Nagasato, Ikuro Maruyama, Naoki Miura
    • Organizer
      2017 American College of Veterinary Internal Medicine Forum
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus Formation System:(T-TAS)の臨床使用例2017

    • Author(s)
      市川華帆、岩永朋子、齋藤靖生、十川英、蔵元智英、古澤悠、高橋香、須永隆文、高橋雅、福島隆治、三浦直樹
    • Organizer
      日本小動物獣医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 房室解離と心室頻拍およびうっ血性心不全を呈した犬の1例2016

    • Author(s)
      岩永朋子
    • Organizer
      第105回日本獣医循環器学会
    • Place of Presentation
      福岡国際会議場(福岡県博多市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 出血傾向を全血血栓形成観測システム(T-TAS)により確認できた犬の3例2016

    • Author(s)
      安川洋子、山田修作、河口貴恵、平尾大樹、橋本梨那、永里朋香、丸山征郎、三浦直樹、岩永朋子、福島隆治
    • Organizer
      第37回動物臨床医学年次大会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Research-status Report
  • [Remarks] あらゆる病気で起こる血液凝固異常を研究して、救命率を上げる!

    • URL

      https://www.kagoshima-u.ac.jp/researcher/2020/04/post-18.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 血栓や止血異常など血液凝固疾患の新規診断法

    • URL

      http://www.rdc.kagoshima-u.ac.jp/seeds_search/upload/25-Ls-iwanaga-vet.pdf

    • Related Report
      2018 Research-status Report

URL: 

Published: 2016-10-24   Modified: 2021-02-19  

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