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Overfill theory in canine and feline glomerular disease: mechanisms, biomarker, and therapyy

Research Project

Project/Area Number 16K08056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionKagoshima University

Principal Investigator

YABUKI AKIRA  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)

Research Collaborator Ichii Osamu  
Yamato Osamu  
Kohyama Moeko  
Sawa Mariko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsオーバーフィル / 糸球体疾患 / 犬 / 猫 / 伴侶動物 / 腎臓 / 糸球体腎症 / 免疫複合体糸球体腎炎 / 非免疫複合体糸球体腎症 / ネフローゼ症候群 / overfill / underdfill / Underfil / Overfil / 伴侶動物臨床獣医学 / 病態メカニズム
Outline of Final Research Achievements

In this study, we analyzed the pathophysiological mechanism of glomerulonephropathy in dogs and cats. Twenty-four cases (17 dogs and 7 cats) were clinically diagnosed with glomerulonephropathy and received renal biopsy (or postmortem renal pathology). As the results, it was suggested that Overfill theory is a rare mechanism in the incidence of nephrotic syndrome in dogs and cats with glomerulonephropathy. The pathophysiological mechanism of all cases with nephrotic syndrome was considered as the classical Underfill theory. In addition, even in the same glomerular disease, the pathological progression mechanism is different between immune complex-mediated glomerulonephritis and non-immune complex-mediated glomerulonephropathy. This difference might be induced by the magnitude of proteinuria.

Academic Significance and Societal Importance of the Research Achievements

糸球体腎症は難治性の腎疾患であり、その治療法も限られている。糸球体腎症はヒトで多く発生する疾患であるが、犬や猫ではその病態がヒト異なっており、ヒトの治療法を簡単には外挿できない。そのため、犬および猫の動物種の特性を明らかにすることが本疾患の治療戦略には欠かせない。本研究は、重篤な臨床症状であるネフローゼ症候群の発生および進行メカニズムの一端を明らかにしたものであり、本疾患の治療戦略の開発に向けて重要な知見を寄与すると期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Changes in renal peritubular capillaries in canine and feline chronic kidney disease.2018

    • Author(s)
      Nakamura R, Yabuki A, Ichii O, Mizukawa H, Yokoyama N, Yamato O.
    • Journal Title

      J Comp Pathol

      Volume: 160 Pages: 79-83

    • DOI

      10.1016/j.jcpa.2018.03.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in lectin-binding patterns in the kidneys of canines with immune-complex mediated glomerulonephritis2018

    • Author(s)
      Yabuki A, Hamamoto T, Rahman MM, Yamato O.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 10 Pages: 1562-1566

    • DOI

      10.1292/jvms.18-0331

    • NAID

      130007502882

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paraffin immunofluorescence for detection of immune complexes in renal biopsies: an efficient salvage technique for diagnosis of glomerulonephritis in dogs2017

    • Author(s)
      Akira Yabuki, Mariko Sawa, Moeko Kohyama, Takeshi Hamamoto, Osamu Yamato
    • Journal Title

      BMC Veterinary research

      Volume: 13 Issue: 1 Pages: 371-371

    • DOI

      10.1186/s12917-017-1287-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 糸球体血栓症の犬の1例2018

    • Author(s)
      矢吹 映、安藤崇則、田邊美加、大和 修
    • Organizer
      第11回日本獣医腎泌尿器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Correlation between renal damage and clinicopathological changes in immune-complex glomerulonephritis and non-immune-complex glomerulonephritis in dogs2018

    • Author(s)
      Akira Yabuki, Takeshi Hamamoto, Yumiko Ohara, Takako Shimokawa, Osamu Yamato
    • Organizer
      The 43th World Small Animal Veterinary Association Congress (WSAVA) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 犬の糸球体疾患における腎組織障害と臨床病態の関連性:免疫複合体糸球体腎炎と非免疫複合体糸球体腎炎の違い2017

    • Author(s)
      矢吹 映、浜本岳志、大原優美子、下川孝子、大和 修
    • Organizer
      平成29年度日本獣医師会獣医学術学会年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 犬の糸球体疾患における腎組織障害と臨床病態の関連性:免疫複合体糸球体腎炎と非免疫複合体糸球体腎炎の違い2017

    • Author(s)
      浜本岳志、矢吹 映、大原優美子、下川孝子、大和 修
    • Organizer
      第10回日本獣医腎泌尿器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Evaluation of the immune complex in renal biopsy of dogs by immunofluorescence of formalin-fixed and paraffin-embedded sections.2017

    • Author(s)
      Akira Yabuki, Mariko Shima-Sawa, Moeko Kohyama, Osamu Yamato.
    • Organizer
      The 42th World Small Animal Veterinary Association Congress (WSAVA) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 犬の腎生検における免疫複合体の検出:ホルマリン固定パラフィン切片を用いた蛍光抗体法2016

    • Author(s)
      矢吹 映,澤 真理子,神山萌子,大和 修
    • Organizer
      第9回日本獣医腎泌尿器学会学術集会
    • Place of Presentation
      連合会館(東京都千代田区)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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