| Project/Area Number |
16K08212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
HAGINAKA Jun 武庫川女子大学, 薬学部, 教授 (20164759)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子インプリントポリマー / 分子認識 / 分析科学 / 薬学 |
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| Outline of Final Research Achievements |
We prepared molecularly imprinted polymers (MIPs) for arbutin, rutin and naringin, which are pharmacologically active compounds (glycones) in herbal medicines. These template molecules were first dissolved in a hydrophilic solvent such as methanol and then the MIPs for those compounds were prepared by modified precipitation polymerization. Especially, the MIP for rutin [quercetin 3-rutinoside (rhamnosyl-glucoside)] recognized rutin among structurally related compounds such as quercetin, quercitrin (quercetin 3-rhamnoside), isoquercitrin (quercetin 3-glucoside), kaempferol, kaempferol 3-rutinoside and kaempferol 3-glycoside. The results indicate that in addition to shape recognition, hydrophilic interactions (the attractive electrostatic interactions) work for the retention and molecular recognition of glycosides on the MIPs.
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| Academic Significance and Societal Importance of the Research Achievements |
従来、調製が難しいとされていた、漢方薬中の親水性の薬理活性物質（配糖体）に対するMIPの調製が修正沈殿重合法により可能となった。調製したMIPを漢方薬中の新規薬理活性物質のスクリーニングおよび同定に適用できる可能性が示唆された。新たに開発した修正沈殿重合法によるMIPの調製法は、親水性の薬理活性物質のみならず、水溶性の生体関連物質、生体高分子化合物の分子認識への適用も期待されるため、ライフサイエンス分野での広範な応用が期待できる。
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