| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
G-quadruplex (G4) structures are stacked nucleic acid structures that can form within G-rich DNA or RNA sequences. In the pathogenesis of neurodegenerative diseases, G4 structures are formed by guanine-rich repeats, which are transcribed, result in forms aggregates with several RNA binding proteins. In this study, we aimed to analyze the components of the RNA-G4/protein complex in the brain and to elucidate the abnormal aggregation mechanism in neurodegenerative diseases. We performed immunoprecipitation using a G4 structural recognition fragment, and identifiedsome novel G4-binding proteins and G4 formed mRNAs in mouse brain.
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