• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of TRPV4 in the regulation of gastrointestinal disorders

Research Project

Project/Area Number 16K08287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

Matsumoto Kenjiro  京都薬科大学, 薬学部, 准教授 (10406770)

Research Collaborator KATO SHINICHI  
TOMINAGA MAKOTO  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炎症性腸疾患 / 味覚 / TRPチャネル / 血管内皮細胞 / 透過性 / 分化 / 酸味 / 大腸炎関連がん / 血管内皮 / 血管透過性 / 温度感受性受容体 / 薬理学 / 生理学
Outline of Final Research Achievements

TRPV4 channel is a non-selective cation channel that responds to mechanical, thermal and chemical stimuli, in addition to various endogenous ligands such as arachidonic acid metabolites. The present study aimed to investigaete the role of TRPV4 in DSS-induced colitis and taste in mice. TRPV4 are highly upregulated in vascular endothelial cells of the colon during DSS-induced colitis.TRPV4 activation induce JNK phosphorylation, and decrease VE-cadherin expression in endothelial cells.An up-regulation of TRPV4 channels in vascular endothelial cells contributes to the progression of colonic inflammation by increasing vascular permeability. We investigated the function and expression of TRPV4 in taste buds using Trpv4-deficient mice. TRPV4 contributes to sour taste sensing by regulating type III taste cell differentiation in mice.

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患は患者のQOLを著しく下げることから、臨床的に大きな問題となっている。しかし、病態については不明な部分が多い。TRPV4は病態時おいて血管内皮細胞に増加し血管透過性を制御することで炎症性細胞の組織への浸潤を調整していることが示唆された。炎症性腸疾患の新たな治療薬標的となることが期待される。
味覚は、甘味、旨味、塩味、酸味、苦味の5味から形成されている。TRPV4が酸味受容に関わっており、Ⅳ型味細胞からⅢ型味細胞への分化を制御していることを示唆するデータを得た。これはTRPV4が酸味の受容において重要な因子であることを示唆するものであり、生理的に非常に意義のある発見である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Transient receptor potential vanilloid 4 mediates sour taste sensing via type III taste cell differentiation.2019

    • Author(s)
      Matsumoto K, Ohishi A, Iwatsuki K, Yamazaki K, Takayanagi S, Tsuji M, Aihara E, Utsumi D, Tsukahara T, Tominaga M, Nagasawa K, Kato S.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6686-6686

    • DOI

      10.1038/s41598-019-43254-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of post-operative ileus2018

    • Author(s)
      Matsumoto Kenjiro、Kawanaka Hiroki、Hori Masatoshi、Kusamori Kosuke、Utsumi Daichi、Tsukahara Takuya、Amagase Kikuko、Horie Syunji、Yamamoto Akira、Ozaki Hiroshi、Mori Yasuo、Kato Shinichi
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology

      Volume: 印刷中 Issue: 1 Pages: G104-G116

    • DOI

      10.1152/ajpgi.00305.2017

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice.2018

    • Author(s)
      Utsumi D, Matsumoto K, Tsukahara T, Amagase K, Tominaga M, Kato S.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 36 Issue: 3 Pages: 121-132

    • DOI

      10.1016/j.jphs.2017.12.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis.2018

    • Author(s)
      Matsumoto K*, Yamaba R, Inoue K, Utsumi D, Tsukahara T, Amagase K, Tominaga M, Kato S.
    • Journal Title

      British Journal of Pharmacology

      Volume: 175 Issue: 1 Pages: 84-99

    • DOI

      10.1111/bph.14072

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity2016

    • Author(s)
      Matsumoto K, Takagi K, Kato A, Ishibashi T, Mori Y, Tashima K, Mitsumoto A, Kato S, Horie S.
    • Journal Title

      Exp Neurol

      Volume: 285 Pages: 41-41

    • DOI

      10.1016/j.expneurol.2016.09.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Involvement of transient receptor potential vanilloid (TRPV4) in the regulation of murine colitis and colitis-associated cancer model2019

    • Author(s)
      松本 健次郎、加藤 伸一
    • Organizer
      日本薬理学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 幼少期マウス社会的敗北ストレスを用いた、過敏性腸症候群モデルの検討2018

    • Author(s)
      松本 健次郎、堀江 俊治、加藤 伸一
    • Organizer
      神経消化器病学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスIBD関連大腸がんの病態における 温度感受性TRPV4チャネルの役割2018

    • Author(s)
      松本 健次郎、天ヶ瀬 紀久子、 加藤 伸一
    • Organizer
      日本潰瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transient Receptor Potential Vanilloid 4 (TRPV4) Regulates Vascular Endothelial Permeability during Colonic Inflammation in Dextran Sulfate Sodium (DSS)-induced Murine Colitis2017

    • Author(s)
      Kenjiro Matsumoto, Daichi Utsumi, Kikuko Amagase, Makoto Tominaga, Shinichi Kato
    • Organizer
      Experimental Biology 2017
    • Place of Presentation
      Chicago
    • Year and Date
      2017-04-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス大腸炎、大腸炎関連がんモデルにおける、TRPV4チャネルの機能2017

    • Author(s)
      深見安希、松本健次郎、内海大知、天ヶ瀬紀久子、富永真琴、加藤伸一
    • Organizer
      日本薬学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 大腸炎および大腸炎関連発癌における血管内皮TRPV4の関与2017

    • Author(s)
      松本健次郎、内海大知、天ヶ瀬紀久子、富永真琴、加藤伸一
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Transient receptor potential vanilloid 4 (TRPV4) regulates vascular endothelial permeability during colonic inflammation in dextran sulfate sodium-induced murine colitis.2017

    • Author(s)
      Matsumoto K, Utsumi D, Amagase K, Tominaga M, Kato S.
    • Organizer
      Experimental Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 1.松本健次郎 難治性消化管疾患の病態制御における温度感受性TRPチャネルおよびセロトニン5-HT3受容体の役割解明2017

    • Author(s)
      松本健次郎
    • Organizer
      生体機能と創薬シンポジウム2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] TNBS誘起内臓痛覚過敏、術後麻痺性イレウスの病態におけるTRPM2の機能解析2017

    • Author(s)
      松本健次郎、堀 正敏、堀江俊治、天ヶ瀬紀久子、尾崎 博、森 泰生、加藤伸一
    • Organizer
      第13回TRPチャネル研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス大腸炎および大腸炎関連発がんにおける血管内皮細胞発現TRPV4の関与2017

    • Author(s)
      松本健次郎、天ヶ瀬紀久子、加藤伸一
    • Organizer
      第35回サイトプロテクション研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Transient Receptor Potential Vanilloid 4 (TRPV4) Regulates Vascular Endothelial Permeability during Colonic Inflammation in Dextran Sulfate Sodium (DSS)-induced Murine Colitis2016

    • Author(s)
      Kenjiro Matsumoto, Daichi Utsumi, Kikuko Amagase, Makoto Tominaga, Shinichi Kato
    • Organizer
      Digestive Weeks 2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] トワイクロス先生のがん緩和ケア処方薬-薬効・薬理と薬の使い方2017

    • Author(s)
      武田 文和
    • Total Pages
      887
    • Publisher
      医学書院
    • ISBN
      4260030310
    • Related Report
      2017 Research-status Report
  • [Remarks] 京都薬科大学 薬物治療学分野ホームページ

    • URL

      http://labo.kyoto-phu.ac.jp/chiryou/chiryou-j.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 京都薬科大学 薬物治療学分野 ホームページ

    • URL

      http://labo.kyoto-phu.ac.jp/chiryou/chiryou-j.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 薬物治療学分野ホームページ

    • URL

      http://labo.kyoto-phu.ac.jp/chiryou/chiryou-j.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi