| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Clarifying regulatory mechanisms of CSF transport kinetics is important to understand central nervous system (CNS) diseases and to develop CNS drug therapeutics. The present study has revealed that the blood-arachnoid barrier, which is composed of arachnoid barrier cells with tight junctions, possesses various transport systems and plays a role as a regulatory system of endogenous substances and CNS drugs transports in the CSF. Here, we propose that the blood-arachnoid barrier functions as the outer blood-CSF barrier, a dynamic interface between the circulating blood and the brain/CSF.
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