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Dysfunction of perivascular adipose tissue exacerbates metabolic syndrome

Research Project

Project/Area Number 16K08563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionMukogawa Women's University

Principal Investigator

KAGOTA Satomi  武庫川女子大学, 薬学部, 准教授 (00291807)

Research Collaborator McGuire John J.  Western University, Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Dr.
Pechanova Olga  Slovak Academy of Sciences, Dr.
Cebova Martina  Slovak Academy of Sciences, Dr.
Cacanyiova Sona  Slovak Academy of Sciences, Dr.
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血管周囲脂肪組織 / 血管弛緩反応 / メタボリックシンドローム / アペリン / metabolic syndrome / perivascular / adipose tissue / vasodilation / adipokine / apelin / 血管周囲脂肪 / 動脈 / 拡張反応 / 循環器・高血圧 / 糖尿病 / 薬理学
Outline of Final Research Achievements

Metabolic syndrome synergistically increases the risk of cardiovascular disease. Perivascular adipose tissue (PVAT) are involved in the regulation of vascular resistance. This study demonstrated that mesenteric arterial PVAT of SHRSP.ZF rats with metabolic syndrome produces and releases apelin and induces arterial dilation by enhancing vascular endothelial nitric oxide production. It was also found that the enhancing effect of PVAT on arterial dilation was seen under conditions of oxidative stress probably via AT1 receptor activation and that the disappearance of PVAT effect may cause organ dysfunction. In conclusion, this research indicates that preservation of PVAT complementary function is a strategy for preventing the onset of cardiovascular disease associated with metabolic syndrome.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、多臓器間クロストークの視点で「メタボリックシンドロームにおける血管周囲脂肪組織(PVAT)と動脈との機能連関」を意識し、「動脈に拡張障害が生じるとPVATが補足的に働き緊張性を保持している」こと、「PVATのバックアップ機能の破綻は臓器の循環障害を招くこと」を立証した点である。本研究の成果は、PVATがメタボリックシンドロームに伴う虚血性臓器障害の発症・進展を抑制するための「新たな標的因子となる」ことを示しており、メタボリックシンドロームの予防・治療法に新しい視点を提供するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] メタボリックシンドロームにおける血管周囲脂肪の血管抵抗性調節機能の経時的変動 ―SHRSP.Z-Leprfa/IzmDmcrラットを用いた検討―2019

    • Author(s)
      籠田智美
    • Journal Title

      SHR等疾患モデル共同研究会News Letter,

      Volume: 60 Pages: 1-2

    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Perivascular adipose tissue-enhanced vasodilation in metabolic syndrome rats by HNO and apelin2018

    • Author(s)
      Satomi Kagota, Kana Maruyama-Fumoto, Saki Iwata, Miho Shimari, Shiori Koyanagi, Yayoi Shiokawa, John J. McGuire, Kazumasa Shinozuka.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Pages: 106-106

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-Dependent Differences in Influence of Perivascular Adipose Tissue on Vasomotor Functions in Metabolic Syndrome2017

    • Author(s)
      Satomi Kagota, Saki Iwata, Kana Maruyama, John J. McGuire, Kazumasa Shinozuka.
    • Journal Title

      Metabolic Syndrome and Related Disorders

      Volume: 0 Issue: 5 Pages: 0-0

    • DOI

      10.1089/met.2016.0146

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] メタボリックシンドロームラットの腎動脈周囲脂肪組織は動脈拡張反応を増強する2019

    • Author(s)
      籠田智美、丸山加菜、山田留衣、島利美保、塩川やよい、篠塚和正
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アペリンはメタボリックシンドロームラットにおいて血管内皮の一酸化窒素生成経路活性化を介して血管弛緩を増強する2019

    • Author(s)
      島利美保、籠田智美、丸山加菜、塩川やよい、篠塚和正
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional characteristics of perivascular adipose tissue on vasodilation in rats with metabolic syndrome.2018

    • Author(s)
      Satomi Kagota, Miho Shimari, Kana Maruyama, Saki Iwata, Noriko Yoshikawa, Kazuki Nakamura, Kazumasa Shinozuka.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Compensatory effects of perivascular adipose tissue on vasodilation differ by vascular site and age in rats with metabolic syndrome2018

    • Author(s)
      Satomi Kagota, Kana Maruyama, Miho Shimari, Yukari Fukunaga, Rui Yamada, Kazumasa Shinozuka.
    • Organizer
      8th International Congress of Pathophysiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deterioration of vasomotor regulation of perivascular adipose tissue at later stage of metabolic syndrome2017

    • Author(s)
      Satomi Kagota, Kana Maruyama, Shiori Koyanagi, Saki Iwata, Kazumasa Shinozuka
    • Organizer
      Council on Hypertension 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] メタボリックシンドロームにおける血管周囲脂肪組織の動脈拡張反応増大効果の機序2017

    • Author(s)
      籠田智美、岩田紗季、丸山加菜、小柳志織、John J McGuire、篠塚和正
    • Organizer
      第90回日本薬理学会年会
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] Effects of perivascular adipose tissue on vasodilation differ by the severity of metabolic disorders2016

    • Author(s)
      Satomi Kagota, Saki Iwata, Kana Maruyama, Shiori Koyanagi, Kazumasa Shinozuka
    • Organizer
      21st World Congress on Heart Disease
    • Place of Presentation
      The Westin Copley Place Boston (MA, USA)
    • Year and Date
      2016-07-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] メタボリックシンドロームにおける血管周囲脂肪の血管抵抗性調節機能の経時的変動

    • URL

      http://plaza.umin.ac.jp/~dmcra/newsletter/img/NewsLetter_No_060.pdf

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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