Molecular mechanisms of neuronal cell death and chromosome segregation errors induced by defects in JSAP-mediated intracellular transport
| Project/Area Number |
16K08579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
Gunarta I Ketut
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細胞死 / 染色体 / マウス / 細胞分裂 / 足場タンパク質 / 遺伝子 / 神経科学 / 癌 |
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| Outline of Final Research Achievements |
JSAP is known to function as an adaptor protein linking cargoes to kinesin/dynein motor proteins. We found that activated axonal JNK moves retrogradely in a dynein-dependent manner in JSAP-deficient neurons, and induces neuronal death. We also suggest that JSAP plays an important role in the regulation of intracellular transport system, and that its impairment by increased expression of JSAP or JSAP loss-of-function is likely to be causative for chromosome segregation errors in dividing cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、軸索輸送の破綻がもたらす神経細胞死は、多くの神経変性疾患に共通の現象である可能性が示唆された。神経細胞死の鍵となる分子を同定し、それらを標的にすることによって、多くの神経変性疾患に有効な治療薬の開発につなげることができると期待される。また、細胞分裂における染色体の不安定性は、がんをはじめとする疾病と密接に関連している。本研究成果は、正確な染色体分配を保証する普遍的な分子メカニズムの解明に貢献すると考えられる。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication.2018
Author(s)
Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 13143-13143
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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