Study of molecular mechanisms of autism spectrus disorders focussing on protein synthesis and proteolysis

• Project/Area Number: 16K08924
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: KASAI Shinya 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
• Co-Investigator(Kenkyū-buntansha): 菊池 尚美 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (30450589)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 自閉症スペクトラム / 結節性硬化症 / 中間表現型 / 脳形態変化 / タンパク質合成 / 薬物治療学

Outline of Final Research Achievements

Tsc2 heterozygous knockout (Tsc2(+/-)) mice exhibited lower wet weight of brain. Regarding for microglial cells and glutamatergic neurons, the expression levels of multiple genes encoding marker molecules were changed in Tsc2(+/-) brains. Expression levels of 1,100 transcripts, accounting for approximately 4.5% of analyzed transcripts, were altered in Tsc2(+/-) mouse brains and reversed by rapamycin. These transcripts were enriched in neoplasm formation, cell differentiation and inflammation.Our findings suggested that increased transcription and translation of genes increase brain wet weight and propensity for tumorgenesis, cell differentiation and inflammation in Tsc2(+/-) brain.

Academic Significance and Societal Importance of the Research Achievements

本研究により分子・細胞メカニズムを明らかにした脳形態変化は、結節性硬化症に併発する自閉症のみならず、自閉症全体の約30%で共通して引き起こされていると考えられており、自閉症における脳病態解明に大きく寄与すると考えられる。また、自閉症の中間表現型である「脳形態異常」の改善薬は、社会的相互作用の異常など自閉症の主要な表現型に対しても奏功する可能性があることから、新しいコンセプト・分子標的の自閉症治療薬開発に繋がると考えられる。

Research Products

• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] Karolinska Institutet(Sweden)
• [Journal Article] Conference Report：第6回アジア神経精神薬理学会 (2020)
  • Author(s): 笠井慎也, 池田和隆
  • Journal Title: 精神科臨床Legato Volume: 6 Pages: 56-57
• [Journal Article] Brain hyperserotonemia causes autism-relevant social deficits in mice. (2018)
  • Author(s): Tanaka M, Sato A, Kasai S, Hagino Y, Kotajima-Murakami H, Kashii H, Takamatsu Y, Nishito Y, Inagaki M, Mizuguchi M, Hall FS, Uhl GR, Murphy D, Sora I, Ikeda K.
  • Journal Title: Mol Autism Volume: 9 Issue: 1 Pages: 60-60
  • DOI: 10.1186/s13229-018-0243-3
  • NAID: 120006543336
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the rs7583431 single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the cold pain test. (2018)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Journal Title: Neuropsychopharmacology Rep Volume: 印刷中 Issue: 2 Pages: 86-91
  • DOI: 10.1002/npr2.12012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test (2018)
  • Author(s): Takahashi K, Nishizawa D, Kasai S, Koukita Y, Fukuda K, Ichinohe T, Ikeda K
  • Journal Title: J Pharmacol Sci Volume: 136(3) Issue: 3 Pages: 107-113
  • DOI: 10.1016/j.jphs.2018.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. (2018)
  • Author(s): 2.Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K.
  • Journal Title: Pharmacogenomics Volume: 19 Issue: 2 Pages: 113-127
  • DOI: 10.2217/pgs-2017-0109
  • Peer Reviewed
• [Journal Article] Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice. (2017)
  • Author(s): 3.Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K.
  • Journal Title: Mol Brain Volume: 10 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s13041-017-0329-4
  • Peer Reviewed / Open Access
• [Journal Article] Conference Report 第5回アジア神経精神薬理学会(AsCNP). (2017)
  • Author(s): 笠井慎也, 池田和隆.
  • Journal Title: 精神科臨床Legato Volume: 3 Pages: 50-51
• [Journal Article] Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese. (2016)
  • Author(s): Kasai S, Nishizawa D, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K
  • Journal Title: Pharmacogenomics Volume: 17(13) Issue: 13 Pages: 1441-1451
  • DOI: 10.2217/pgs.15.184
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery. (2016)
  • Author(s): Muraoka W, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Wajima K, Nakagawa T, Ikeda K
  • Journal Title: Mol Pain Volume: 12 Pages: 1-12
  • DOI: 10.1177/1744806916683182
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2015)
  • Author(s): Mieda T, Nishizawa D, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
  • Journal Title: Pharmacogenomics Volume: 17 Issue: 2 Pages: 133-145
  • DOI: 10.2217/pgs.15.151
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Transcriptome analyses in rodent models and postmortem human brains. (2019)
  • Author(s): Kasai S, Ikeda K.
  • Organizer: AsCNP-ASEAN2019
  • Int'l Joint Research / Invited
• [Presentation] Transcriptome signatures of opioid misuse with human postmortem medulla. (2019)
  • Author(s): Kasai S, Bogdanovic N, Alkass K, Druid H.
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research / Invited
• [Presentation] Associations between genetic polymorphisms on chromosome 14q32 and effects of opioid analgesics and chronic pain. (2019)
  • Author(s): Kosaki Y, Nishizawa D, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K.
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] Association between the rs11726196 single-nucleotide polymorphism within the transient receptor subfamily C member 3 (TRPC3) gene and chronic pain. (2019)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Ogawa S, Hiranuma A, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K.
  • Organizer: 6th Congress of Asian College of Neuropsychopharmacology (AsCNP2019)
  • Int'l Joint Research
• [Presentation] ゲノムワイド関連解析(GWAS)による慢性痛及び帯状疱疹後神経痛感受性遺伝子の同定. (2019)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 平沼彩子, 笠井慎也, 長谷川合準子, 江畑裕子, 中山京子, 林田眞和, 池田和隆.
  • Organizer: 日本人類遺伝学会第64回大会
• [Presentation] ドーパミン欠乏マウスを用いた各種自発行動のおけるドーパミン依存症の解析. (2018)
  • Author(s): 藤田雅代, 萩野洋子, 武田大志, 笠井慎也, 高松幸雄, 池田和隆.
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析(GWAS)による冷水誘発疼痛試験におけるフェンタニルの鎮痛効果と関連する遺伝子多型の同定. (2018)
  • Author(s): 西澤大輔, 髙橋香央里, 吉田香織, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 高北義彦, 福田謙一, 一戸達也, 池田和隆.
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] プロポフォール投与後の効果部位濃度におけるCYP2B6の遺伝子多型の影響. (2018)
  • Author(s): 髙橋香央里, 西澤大輔, 山田芳嗣, 笠井慎也, 須野学, 高北義彦, 一戸達也, 福田謙一, 池田和隆.
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
• [Presentation] Autistic-like behavioral deficits are severer in Tsc2 than Tsc1 haploinsufficiency in mouse models of TSC. (2018)
  • Author(s): Sato A, Tanaka M, Kashii H, Kotajima-Murakami H, Kasai S, Hagino Y, Kobayashi T, Hino O, Mizuguchi M, Ikeda K.
  • Organizer: 国際TSCリサーチカンファレンス2018 (ITSCRC2018)
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies genetic polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2018)
  • Author(s): Nishizawa D, Takahashi K, Yoshida K, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Koukita Y, Fukuda K, Ichinohe T, Ikeda K.
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] Gene expression profile of dopamine-deficient mouse brain for underlying molecular pathology in psychiatric disorders. (2018)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K.
  • Organizer: 31st CINP World Congress
  • Int'l Joint Research
• [Presentation] The orexin (hypocretin) receptor 2 gene polymorphism Val308Ile associated with nicotine dependence. (2018)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Hayashida M, Sugimura H, Ikeda K.
  • Organizer: 2018 NIDA International Forum
  • Int'l Joint Research
• [Presentation] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence found in genome-wide and subsequent association studies. (2018)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Hayashida M, Sugimura H, Ikeda K.
  • Organizer: CPDD 80th Annual Scientific Meeting
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスの自閉症様行動に関わる遺伝子発現変化の解析. (2018)
  • Author(s): 柏井洋文, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 池田和隆, 岡明, 水口雅.
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] セロトニントランスポーター欠損マウスの自閉症様行動はトリプトファン欠乏食によって改善する. (2018)
  • Author(s): 佐藤敦志, 田中美歩, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 水口雅, 池田和隆.
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] Gene expression profile corresponding to autism-like behaviors in mouse models of tuberous sclerosis complex. (2018)
  • Author(s): Kashii H, Kasai S, Hagino Y, Sato A, Kotajima H, Tanaka M, Kobayashi T, Hino O, Oka A, Mizuguchi M, Ikeda K.
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
  • Int'l Joint Research
• [Presentation] Circadian rhythm is maintained in dopamine-deficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda TC, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K.
  • Organizer: The 56th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 56th Annual Meeting)
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスにおける幼若期NMDA投与による点頭様発作の解析. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 岡明, 水口雅, 池田和隆.
  • Organizer: 第51回日本てんかん学会年次学術集会
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に影響する遺伝子多型の同定. (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆.
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] Tsc2 ヘテロ欠損マウスの自閉症様行動に対するrapamycinの継続投与の効果とその副作用の検討. (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 水口雅, 池田和隆.
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果. (2017)
  • Author(s): 田中美歩, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 池田和隆.
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] Transcriptome profiling of dopamine-deficient mouse brain. (2017)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K.
  • Organizer: 第60回日本神経化学会大会
  • Invited
• [Presentation] 各種自発行動におけるドーパミン依存性の解析. (2017)
  • Author(s): 藤田雅代, 萩野洋子, Takeda T, 笠井慎也, 高松幸雄, 池田和隆.
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
• [Presentation] Association of Proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese. (2017)
  • Author(s): Kasai S, Nishizawa D, Higuchi S, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Invited
• [Presentation] Rapamycin treatment of impaired social behavior in adolescent Tsc2+/－mice. (2017)
  • Author(s): Kashii H, Hagino Y, Kasai S, Kotajima H, Sato A, Kobayashi T, Hino O, Mizuguchi M, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
• [Presentation] Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. (2017)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
• [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity. (2017)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
• [Presentation] Molecular mechanisms underlying individual differences in pain and analgesic sensitivity. (2017)
  • Author(s): Kasai S, Ikeda K.
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Invited
• [Presentation] Opioid receptor-related genes associated with smoking/tobacco use in Japanese. (2016)
  • Author(s): Kasai S, Sugimura H, Ikeda K.
  • Organizer: 17th Pacific Rim College of Psychiatrists Scientific Meeting (PRCP2016)
  • Place of Presentation: Kaohsiung Exhibition Center, Kaohsiung, Taiwan
  • Year and Date: 2016-11-03
  • Int'l Joint Research / Invited
• [Presentation] ドーパミン欠乏マウスにおける異常性行動の脳内メカニズム. (2016)
  • Author(s): 藤田雅代, Takeda TC, 萩野洋子, 笠井慎也, 橋本款, 小林和人, 池田和隆.
  • Organizer: 第51回日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K.
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: PACIFICO Yokohama, Yokohama, Kanagawa
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] 鎮痛薬感受性と関連するオピオイドペプチド遺伝子多型の解析. (2016)
  • Author(s): 笠井慎也, 西澤大輔, 林田眞和, 長島誠, 加藤良二, 池田和隆.
  • Organizer: 第3回包括的緩和医療科学学術研究会／第4回Tokyo 疼痛緩和次世代研究会
  • Place of Presentation: TKPガーデンシティ永田町（東京千代田区）
  • Year and Date: 2016-08-28
• [Presentation] タバコ・ニコチン依存に影響を及ぼすオピオイド受容体関連遺伝子. (2016)
  • Author(s): 笠井慎也, 西澤大輔, 佐藤直美, 谷岡書彦, 椙村春彦, 池田和隆.
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学薬学部（北海道札幌市）
  • Year and Date: 2016-08-20
• [Presentation] Cav2.3(R型)電位依存性Ca2+チャネル遺伝子多型と鎮痛薬感受性との関連. (2016)
  • Author(s): 井手総一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆.
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学薬学部（北海道札幌市）
  • Year and Date: 2016-08-20
• [Presentation] Transcriptome analysis in Tsc2 heterozygous knockout mice. (2016)
  • Author(s): Kasai S, Sato A, Kashii H, Kobayashi T, Hino O, Mizuguchi M, Ikeda K.
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Association between the rs7583431single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2016)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K.
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M.
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: COEX, Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Activating transcription factor 2 (ATF2)遺伝子近傍の遺伝子多型rs7583431と冷水誘発疼痛試験におけるフェンタニルの鎮痛効果との関連. (2016)
  • Author(s): 青木謙典, 西澤大輔, 吉田香織, 長谷川準子, 笠井慎也, 髙橋香央里, 髙北義彦, 一戸達也, 林田眞和, 福田謙一, 池田和隆.
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: COEX, ソウル, 韓国
  • Year and Date: 2016-07-03
• [Presentation] レミフェンタニル・プロポフォール全静脈麻酔中にフェンタニルの追加投与を必要とした症例の遺伝子多型. (2016)
  • Author(s): 髙橋香央里, 福田謙一, 西澤大輔, 笠井慎也, 須野学, 髙北義彦, 一戸達也, 池田和隆.
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: COEX, ソウル, 韓国
  • Year and Date: 2016-07-03
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定. (2016)
  • Author(s): 西澤大輔, 三枝勉, 中川秀之, 美紀, 今西宏和, 寺尾和久, 吉川博昭, 伊藤一志, 天野功二郎, 田代浄, 石井利昌, 有山淳, 山口茂樹, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 池田和隆, 北村晶, 林田眞和.
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: COEX, ソウル, 韓国
  • Year and Date: 2016-07-02
• [Presentation] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing orthognathic surgery. (2016)
  • Author(s): Muraoka W, Saisu H, Sato H, Usuda S, Inoue M, Ochiai S, Nishizawa D, Hasegawa J, Kasai S, Nakagawa T, Wajima K, Fukuda K, Ikeda K.
  • Organizer: American Academy of Orofacial Pain 40th Scientific Meeting
  • Place of Presentation: Lake Buena Vista, Florida, USA
  • Year and Date: 2016-04-14
  • Int'l Joint Research