Prognostic factor analysis and genomic prognostic factor analysis for early staged cancers

• Project/Area Number: 16K09044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Tokai University
• Principal Investigator: Shibata Takeo 東海大学, 健康学部, 講師 (30366033)
• Research Collaborator: Endo Arihito
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 予後因子 / 癌 / 遺伝子 / SEER / ICGC / 機械学習 / がんデータベース / 乳がん / 卵巣がん / 子宮がん / 大腸がん / 乳癌 / 大腸癌 / 子宮癌 / 早期癌 / 予後不良因子 / 米国がん登録データベース / 国際がんゲノムコンソーシアム

Outline of Final Research Achievements

Japanese characteristics were analyzed with SEER(Surveillance Epidemiology and End Results) cancer database.
Relationships between pathological grades and gene expression levels were analyzed with ICGC(International Cancer Genome Consortium) breast cancer database.

Academic Significance and Societal Importance of the Research Achievements

全体的に予後が良い早期癌の中でも早期に再発・転移して亡くなるケースがある。海外には大規模ながんデータベースがあり、それらを網羅的に解析することでその原因因子を推定することが期待できる。それらの因子がわかれば、早期癌においても積極的に補助療法を行うべきかどうか考慮することができる。また、原因遺伝子がわかれば、検査によって予後を推定したり、それをターゲットにした治療法の開発を試みるなど、早期癌で短期間で亡くなる人を減少させるための医学の進歩に貢献できる可能性がある。

Research Products

• [Journal Article] Usefulness of the Universal Adapter for Smartphones in a Mannequin Study (2018)
  • Author(s): Junko Ajimi, Junichi Nishiyama, Ritsuko Masuda, Takeo Shibata, Hiroyuki Furuya, Sadanori Hosoi, Akiko Soejima, Toshiyasu Suzuki
  • Journal Title: Tokai J Exp Clin Med Volume: 43(4) Pages: 139-142
  • Peer Reviewed
• [Journal Article] Airtraq DL and AWS-200 for Double-lumen Endotracheal Tube Intubation: A Prospective Randomized Clinical Trial (2018)
  • Author(s): Junko Ajimi, Junichi Nishiyama, Ritsuko Masuda, Takeo Shibata, Toshiyasu Suzuki
  • Journal Title: Tokai J Exp Clin Med Volume: 43(4) Pages: 161-167
  • Peer Reviewed
• [Journal Article] Impact of institutional accreditation by the Japan Society of Gynecologic Oncology on the treatment and survival of women with cervical cancer (2018)
  • Author(s): Mikami Mikio、Shida Masako、Shibata Takeo、Katabuchi Hidetaka、Kigawa Junzo、Aoki Daisuke、Yaegashi Nobuo
  • Journal Title: Journal of Gynecologic Oncology Volume: 29 Issue: 2
  • DOI: 10.3802/jgo.2018.29.e23
  • Peer Reviewed / Open Access
• [Journal Article] Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma (2018)
  • Author(s): Matsuo Koji、Tanabe Kazuhiro、Ikeda Masae、Shibata Takeo、Kajiwara Hiroshi、Miyazawa Masaki、Miyazawa Mariko、Hayashi Masaru、Shida Masako、Hirasawa Takeshi、Roman Lynda D.、Mikami Mikio
  • Journal Title: Archives of Gynecology and Obstetrics Volume: 297 Issue: 3 Pages: 749-756
  • DOI: 10.1007/s00404-018-4658-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Congenital anomalies of the left brachiocephalic vein detected in adults on computed tomography (2017)
  • Author(s): Yamamuro Hiroshi、Ichikawa Tamaki、Hashimoto Jun、Ono Shun、Nagata Yoshimi、Kawada Shuichi、Kobayashi Makiko、Koizumi Jun、Shibata Takeo、Imai Yutaka
  • Journal Title: Japanese Journal of Radiology Volume: 35 Issue: 10 Pages: 597-605
  • DOI: 10.1007/s11604-017-0673-4
  • NAID: 50012797146
  • Peer Reviewed
• [Journal Article] 産婦人科医師リクルート活動へのヒント発掘 ―第1 報 神奈川県内私立大学医学生への調査 (2017)
  • Author(s): 三上幹男,信田政子,柴田健雄,明石敏男,新井努,新井正秀,五十嵐豪,石本人士,伊藤めぐむ,小川公一,榊原秀也,染谷健一,中沢和美,長塚正晃,西井修,平吹知雄,松島隆,持丸佳之,角田新平,鈴木直,海野信也,野眞佐男,高橋恒男
  • Journal Title: 日医雑誌 Volume: 145(10) Pages: 2155-2162
  • NAID: 40021047109
  • Peer Reviewed
• [Journal Article] 産婦人科医師リクルート活動へのヒント発掘 ―第2 報 神奈川県内初期臨床研修医への調査 (2017)
  • Author(s): 三上幹男,信田政子,柴田健雄,明石敏男,新井努,新井正秀,五十嵐豪,石本人士,伊藤めぐむ,小川公一,榊原秀也,染谷健一,中沢和美,長塚正晃,西井修,平吹知雄,松島隆,持丸佳之,角田新平,鈴木直,海野信也,野眞佐男,高橋恒男
  • Journal Title: 日医雑誌 Volume: 145(10) Pages: 2163-2168
  • NAID: 40021047152
  • Peer Reviewed
• [Journal Article] Lactococcus lactis JCM5805 activates anti-viral immunity and reduces symptoms of common cold and influenza in healthy adults in a randomized controlled trial (2016)
  • Author(s): Takeo Shibata, Masaya Kanayama, Munetaka Haida, Shuhei Fujimoto, Takashige Oroguchi, Kenji Sata, Nobutaka Mita, Tomoko Kutsuzawa, Mayumi Ikeuchi, Mayu Kondo, Kimitoshi Naito, Michio Tsuda, Yasuhiro Nishizaki, Naoaki Ishii
  • Journal Title: Journal of Functional Foods Volume: 24 Pages: 492-500
  • Peer Reviewed