| Project/Area Number |
16K09072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山岸 良匡 筑波大学, 医学医療系, 准教授 (20375504)
本庄 かおり 大阪医科大学, 医学部, 教授 (60448032)
斉藤 功 大分大学, 医学部, 教授 (90253781)
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| Research Collaborator |
TANIGAWA Takeshi
ISO Hiroyasu
MARUYAMA Koutatsu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | αアミラーゼ / 動脈硬化 / 横断研究 / 社会心理要因 / コホート研究 / 糖尿病 / 社会的要因 / 心理的ストレス / 社会心理的要因 / 性差 |
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| Outline of Final Research Achievements |
Although this study was the cross-sectional design, which limited our ability to draw causal inferences, we found the associations between α-amylase and social factors such as socioeconomic and marital conditions (low educational background, irregular employment, unmarried). We also found that α-amylase was associated with the prevalence of atherosclerosis. Furthermore, in women, α-amylase was related to decreased in parasympathetic nervous activity, and increased the levels of blood pressure, fasting plasma glucose, and insulin resistance and sensitivity, which has been identified as important risk factors of atherosclerosis.
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| Academic Significance and Societal Importance of the Research Achievements |
大規模研究の多くは、個人の精神的ストレスを自記式質問紙調査で把握しているのが現状であるが、本研究のように、ストレス関連マーカーである唾液中のαアミラーゼを測定し、社会的要因がストレス反応を介して動脈硬化に及ぼす影響について、精度の高い詳細な検査情報を有するコホートを用いて、生物学的な側面から検討した研究は国内外いずれにも見られない。
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