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The mechanism of sex differences in the association between psychosocial factors and atherosclerosis

Research Project

Project/Area Number 16K09072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionJuntendo University

Principal Investigator

Noda (Ikeda) Ai  順天堂大学, 医学部, 特任准教授 (10616121)

Co-Investigator(Kenkyū-buntansha) 山岸 良匡  筑波大学, 医学医療系, 准教授 (20375504)
本庄 かおり  大阪医科大学, 医学部, 教授 (60448032)
斉藤 功  大分大学, 医学部, 教授 (90253781)
Research Collaborator TANIGAWA Takeshi  
ISO Hiroyasu  
MARUYAMA Koutatsu  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsαアミラーゼ / 動脈硬化 / 横断研究 / 社会心理要因 / コホート研究 / 糖尿病 / 社会的要因 / 心理的ストレス / 社会心理的要因 / 性差
Outline of Final Research Achievements

Although this study was the cross-sectional design, which limited our ability to draw causal inferences, we found the associations between α-amylase and social factors such as socioeconomic and marital conditions (low educational background, irregular employment, unmarried). We also found that α-amylase was associated with the prevalence of atherosclerosis. Furthermore, in women, α-amylase was related to decreased in parasympathetic nervous activity, and increased the levels of blood pressure, fasting plasma glucose, and insulin resistance and sensitivity, which has been identified as important risk factors of atherosclerosis.

Academic Significance and Societal Importance of the Research Achievements

大規模研究の多くは、個人の精神的ストレスを自記式質問紙調査で把握しているのが現状であるが、本研究のように、ストレス関連マーカーである唾液中のαアミラーゼを測定し、社会的要因がストレス反応を介して動脈硬化に及ぼす影響について、精度の高い詳細な検査情報を有するコホートを用いて、生物学的な側面から検討した研究は国内外いずれにも見られない。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) Remarks (1 results)

  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Association Between Heart Rate Variability and Home Blood Pressure: The Toon Health Study.2018

    • Author(s)
      Saito I, Takata Y, Maruyama K, Eguchi E, Kato T, Shirahama R, Tomooka K, Kawamura R, Sano M, Tabara Y, Osawa H, Tanigawa T.
    • Journal Title

      Am J Hypertens.

      Volume: 31 Issue: 10 Pages: 1120-1126

    • DOI

      10.1093/ajh/hpy100

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 地域住民における唾液中αアミラーゼと血圧との関連:東温スタディ2019

    • Author(s)
      世古ゆり子,池田愛,友岡清秀,斉藤功,丸山広達,谷川武
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域住民における唾液中αアミラーゼと軽度認知障害との関連:東温スタディ2019

    • Author(s)
      山根七歩,池田愛,友岡清秀,斉藤功,丸山広達,谷川武
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域住民における唾液中αアミラーゼと動脈硬化との関連:東温スタディ2019

    • Author(s)
      高橋香帆,池田愛,友岡清秀,斉藤功,丸山広達,谷川武
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心拍変動と身体活動量に関する疫学研究 東温スタディ.心拍変動と身体活動量に関する疫学研究 東温スタディ2018

    • Author(s)
      斉藤 功, 丸山 広達, 友岡 清秀, 加藤 匡宏, 谷川 武
    • Organizer
      第77回日本公衆衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心拍変動と家庭血圧に関する疫学研究:東温スタディ2017

    • Author(s)
      斉藤功
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Remarks] 東温スタディ | 地域住民とともに歩む疫学研究と予防活動

    • URL

      https://www.toon-study.jp/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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