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Analysis for mechanism involved in the suppressed immune response of CTL under exposure to asbestos

Research Project

Project/Area Number 16K09114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionKawasaki Medical School

Principal Investigator

TAKEI NAOKO  川崎医科大学, 医学部, 講師 (00509276)

Co-Investigator(Kenkyū-buntansha) 大槻 剛巳  川崎医科大学, 医学部, 教授 (40160551)
西村 泰光  川崎医科大学, 医学部, 准教授 (90360271)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords石綿 / 中皮腫 / CTL / IL-15 / granzyme B / perforin / 免疫応答 / 悪性中皮腫
Outline of Final Research Achievements

IL-15 insufficiency is not the main cause for the suppressed induction of CTLs by asbestos exposure, although they suggest a potential for the improvement of such suppressed CTL functions. The long-term cultures of the human CD8+ T cell line with exposure to asbestos showed decreased intracellular levels of perforin and production of IFN-γ. These characteristics represented functional alterations, similar to that of peripheral blood CD8+ T cells in patients with mesothelioma.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、石綿曝露による癌疾患の発症に対する医学的基盤情報としても重要である。我が国では、現在、石綿の職業曝露から環境曝露への拡大が社会問題となっている。悪性中皮腫は予後が悪く、また、診断は容易ではないが、CD8+T細胞は末梢血より容易に採取・試験出来ることから、本研究成果は悪性中皮腫発症の早期予防にむけての各種CTL機能に基づく検査法の確立及び治療方法の構築にも貢献できると考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Book (4 results) Remarks (3 results)

  • [Journal Article] Inflammatory alteration of human T cells exposed continuously to asbestos.2018

    • Author(s)
      Kumagai-Takei N, Yamamoto S, Lee S, Maeda M, Matsuzaki H, Sada N, Yu M, Yoshitome K, Nishimura Y, Otsuki T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 2 Pages: 504-504

    • DOI

      10.3390/ijms19020504

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8+ T Cell Line following Long-Term Exposure to Asbestos Fibers2018

    • Author(s)
      Kumagai-Takei Naoko、Nishimura Yasumitsu、Matsuzaki Hidenori、Lee Suni、Yoshitome Kei、Otsuki Takemi
    • Journal Title

      Journal of Immunology Research

      Volume: 2018 Pages: 1-10

    • DOI

      10.1155/2018/4391731

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] アスベト曝露と細胞傷害性顆粒.2017

    • Author(s)
      武井直子,西村泰光,松﨑秀紀,李順姫,吉留敬,幡山圭代, 山本祥子,池田美穂,大槻剛巳.
    • Journal Title

      臨床環境医学 26(1): 31-37, 2017

      Volume: 26 Pages: 31-37

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Suppressed Induction of Human Mature Cytotoxic T Lymphocytes Caused by Asbestos Is Not due to Interleukin-2 Insufficiency2016

    • Author(s)
      Kumagai-Takei, N. Nishimura, Y. Matsuzaki, H. Lee, S. Yoshitome, K. Hayashi, H. Otsuki, T.
    • Journal Title

      J Immunol Res

      Volume: 2016 Pages: 1-10

    • DOI

      10.1155/2016/7484872

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 石綿曝露下CTL分化抑制時の補助刺激分子の役割2020

    • Author(s)
      武井直子、西村泰光、李順姫、吉留敬、伊藤達男、大槻剛巳.
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IL-15に注目したCTL分化に及ぼす石綿曝露影響の機序解析2019

    • Author(s)
      武井直子、西村泰光、李順姫、吉留敬、大槻剛巳.
    • Organizer
      第26回日本免疫毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IL-15-induced recovery of suppressed proliferation and granzyme B level of CTL upon exposure to asbestos during MLR2019

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Otsuki T.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 石綿曝露下CTL分化抑制時の細胞増殖と granzyme B産生に対するIL-15の影響2019

    • Author(s)
      武井直子、西村泰光、松﨑秀紀、李順姫、吉留敬、大槻剛巳
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒト CD8+T 細胞株を用いて作成した石綿曝露亜株の機能解析2018

    • Author(s)
      武井直子、西村泰光、松﨑秀紀、李順姫、吉留敬、大槻剛巳
    • Organizer
      第25回 石綿・中皮腫研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] The functional analysis of human CD8+ T cell line with long-term exposure to chrysotile asbestos fibers2018

    • Author(s)
      Kumagai-Takei N. Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Otsuki T.
    • Organizer
      The 57thAnnual Meeting of the Society of Toxicology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 長期石綿曝露がヒトCD8+T細胞亜株の機能に与える影響.2017

    • Author(s)
      武井直子,西村泰光,松﨑秀紀,李順姫,吉留敬,大槻剛巳.
    • Organizer
      第87回日本衛生学会学術総会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Differential effects of IL-2 and IL-15 addition on numbers and granzyme B level in CD8+ lymphocytes exposed to asbestos during MLR.2017

    • Author(s)
      Kumagai-Takei N. Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Otsuki T.
    • Organizer
      The 56th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore Convention Center (Maryland, USA)
    • Year and Date
      2017-03-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 長期石綿曝露によるヒトCD8T細胞の機能変化.2017

    • Author(s)
      武井直子、西村泰光、松﨑秀紀、李順姫、吉留敬、大槻剛巳.
    • Organizer
      第24回日本免疫毒性学会学術年会
    • Related Report
      2017 Research-status Report
  • [Presentation] The analysis for function of human CD8+T cell line with and without long-term exposure to asbestos fibers.2017

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Otsuki T.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Differential effects of IL-2 and IL-15 on the suppressed induction of CTL upon exposure to asbestos.2016

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Otsuki T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(那覇市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 石綿曝露下 CTL 分化抑制時の CD8+T 細胞に及ぼす IL-15 添加の影響.2016

    • Author(s)
      武井直子,西村泰光,松﨑秀紀,李順姫,吉留敬,大槻剛巳.
    • Organizer
      第23回日本免疫毒性学会学術年会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 石綿曝露によるCTL分化抑制時のIL-15添加の影響.2016

    • Author(s)
      武井直子,西村泰光,松﨑秀紀,李順姫,吉留敬,大槻剛巳.
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Book] Reduction of anti-tumor immunity caused by asbestos exposure. In: Allergy and Immunotoxicology in Occupational Health - The Next Step2020

    • Author(s)
      Kumagai-Takei N, Lee S, Matsuzaki H, Maeda M, Sada N,Yu M, Yoshitome K, Nishimura Y, Otsuki T.
    • Publisher
      Springer Japan
    • Related Report
      2019 Annual Research Report
  • [Book] Immune alteration caused by fibrous and particulate environmental substances. In: Environmental Factors affecting Human Health.2019

    • Author(s)
      Kumagai-Takei N, Lee S, Yoshitome K, Sada N, Nishimura Y, Otsuki T.
    • Total Pages
      17
    • Publisher
      IntechOpen Limited
    • Related Report
      2019 Annual Research Report
  • [Book] Alteration of perforin status caused by asbestos exposure in CTL and NK cellss. In. "Advances in Medicine and Biology.2017

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Yamamoto S, Ikeda M, Hatayama T, Maeda M, Otsuki T.
    • Publisher
      NOVA Science Publishers, Inc.
    • Related Report
      2017 Research-status Report
  • [Book] Reduction of anti-tumor immunity caused by asbestos exposure.In. Asbestos: Risk Assessment, Health Implications and Impacts on the Environment.2016

    • Author(s)
      Kumagai-Takei N, Nishimura Y, Matsuzaki H, Lee S, Yoshitome K, Yamamoto S, Hatayama T, Maeda M, Otsuki T.
    • Publisher
      NOVA Scientific Publishers, Inc.
    • Related Report
      2016 Research-status Report
  • [Remarks] 川崎医科大学衛生学ホームページ 業績紹介

    • URL

      https://m.kawasaki-m.ac.jp/hygiene/151116_BIBLIO2019.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 川崎医科大学衛生学ホームページ 業績紹介

    • URL

      https://m.kawasaki-m.ac.jp/hygiene/151116_BIBLIO2018.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 川崎医科大学衛生学オリジナルホームページ 業績紹介

    • URL

      https://m.kawasaki-m.ac.jp/hygiene/151116_BIBLIO.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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