Role of gut microbiome on pathophysiology of brain-gut interaction in irritable bowel syndrome

• Project/Area Number: 16K09227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: KANAZAWA Motoyori 東北大学, 医学系研究科, 准教授 (70323003)
• Co-Investigator(Kenkyū-buntansha): 鹿野 理子 東北大学, 医学系研究科, 大学院非常勤講師 (20344658) ; 村椿 智彦 東北大学, 医学系研究科, 助教 (70741007) ; 福土 審 東北大学, 医学系研究科, 教授 (80199249)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 過敏性腸症候群 / 腸内細菌 / 脳腸相関 / 腸内細菌叢 / 細菌 / ストレス / 心療内科学

Outline of Final Research Achievements

It has been unknown how the intestinal bacterial production of metabolites are associated with pathophysiology of irritable bowel syndrome (IBS). The aims of the present study were to investigate whether fecal bacterial metagenome function alters in IBS patients.
We found that the relative abundances of gut microbial composition were different between IBS patients and healthy controls (HC) and that the bacterial pathways for amino acid metabolism were more enriched in IBS compared with HC.
These findings suggest that altered amino acid metabolism of gut microbiome may contribute to pathophysiology of IBS.

Academic Significance and Societal Importance of the Research Achievements

腸内細菌の代謝機能の視点から有病率が高くストレス関連疾患の１つである過敏性腸症候群（IBS）における脳腸相関の病態を解明することによって、腸内環境に対するIBS治療法の確立に向けた新たな基盤を築くことができた。すなわち、IBS患者に対して腸内細菌叢の変化とその代謝機能の改善に焦点を当てた新たな治療法の開発が期待できるであろう。

Research Products

• [Journal Article] Insula Activity to Visceral Stimulation and Endocrine Stress Responses as Associated With Alexithymia in Patients With Irritable Bowel Syndrome. (2020)
  • Author(s): Kano M, Muratsubaki T, Yagihashi M, Morishita J, Mugikura S, Dupont P, Takase K, Kanazawa M, Van Oudenhove L, Fukudo S
  • Journal Title: Psychosom Med Volume: 82 Issue: 1 Pages: 29-38
  • DOI: 10.1097/psy.0000000000000729
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 【下痢と便秘の臨床 機能性疾患診療の深化】ガイドラインに基づいた実地医家のためのオーバービュー 過敏性腸症候群の最新診療 診療ガイドライン2014発刊とその後の進歩 (2020)
  • Author(s): 金澤素、福土審.
  • Journal Title: Medical Practice Volume: 37 Pages: 182-189
• [Journal Article] 特集 ストレス関連疾患の合併症状 特集にあたって (2020)
  • Author(s): 金澤素.
  • Journal Title: 心身医学 Volume: 60 Pages: 19-19
• [Journal Article] 特集 診療力を上げる! 症例問題集 第2章 消化器 症例問題 過敏性腸症候群の分類と初期治療 (2019)
  • Author(s): 金澤素、福土審.
  • Journal Title: 内科 Volume: 123 Issue: 4 Pages: 571-573
  • DOI: 10.15106/j_naika123_571
  • ISSN: 0022-1961, 2432-9452
  • Year and Date: 2019-04-01
• [Journal Article] Parasympathetic activity correlates with subjective and brain responses to rectal distension in healthy subjects but not in non-constipated patients with irritable bowel syndrome. (2019)
  • Author(s): Kano M, Yoshizawa M, Kono K, Muratsubaki T, Morishita J, Van Oudenhove L, Yagihashi M, Mugikura S, Dupont P, Takase K, Kanazawa M, Fukudo S
  • Journal Title: Sci Rep Volume: 14 Issue: 1 Pages: 7358-7358
  • DOI: 10.1038/s41598-019-43455-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 【腸内細菌と消化器疾患】腸内細菌と各疾患の関連についての最新知見 腸内細菌と過敏性腸症候群 (2019)
  • Author(s): 金澤素、福土審.
  • Journal Title: 消化器の臨床 Volume: 22 Pages: 107-116
• [Journal Article] 【機能性消化管疾患:下部-最新の診断と治療-】基礎研究 過敏性腸症候群と腸内細菌叢の異常 (2019)
  • Author(s): 金澤素、福土審.
  • Journal Title: 日本臨牀 Volume: 77 Pages: 1767-1775
• [Journal Article] 【消化管感染症のすべて】感染性腸炎後過敏性腸症候群 (2019)
  • Author(s): 金澤素、福土審.
  • Journal Title: 消化器内視鏡 Volume: 31 Pages: 197-199
• [Journal Article] 慢性便秘の治療－上皮機能変容薬、胆汁酸トランスポーター阻害薬の使い分け－． (2019)
  • Author(s): 福土審、遠藤由香、金澤素．
  • Journal Title: 日内会誌 Volume: 108 Pages: 46-54
  • Peer Reviewed / Open Access
• [Journal Article] Influence of the requirement for abdominal pain in the diagnosis of irritable bowel syndrome with constipation (IBS-C) under the Rome IV criteria using data from a large Japanese population-based internet survey. (2018)
  • Author(s): Kosako M, Akiho H, Miwa H, Kanazawa M, Fukudo S.
  • Journal Title: Biopsychosoc Med Volume: 12 Issue: 1 Pages: 18-18
  • DOI: 10.1186/s13030-018-0137-9
  • Peer Reviewed / Open Access
• [Journal Article] Impact of symptoms by gender and age in Japanese subjects with irritable bowel syndrome with constipation (IBS-C): a large population-based internet survey. (2018)
  • Author(s): Kosako M, Akiho H, Miwa H, Kanazawa M, Fukudo S.
  • Journal Title: Biopsychosoc Med Volume: 12 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s13030-018-0131-2
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between sympathoadrenal and pituitary-adrenal response during colorectal distention in the presence of corticotropin-releasing hormone in patients with irritable bowel syndrome and healthy controls. (2018)
  • Author(s): Tanaka Y, Kanazawa M, Kano M, Tashiro M, Fukudo S.
  • Journal Title: PLoS One Volume: 13 Issue: 7 Pages: 1-16
  • DOI: 10.1371/journal.pone.0199698
  • Peer Reviewed / Open Access
• [Journal Article] 過敏性腸症候群：診療ガイドラインに基づいた治療戦略． (2018)
  • Author(s): 金澤素、福土審．
  • Journal Title: 消化器・肝臓内科 Volume: 4 Pages: 285-291
• [Journal Article] Increased postprandial colonic motility and autonomic nervous system activity in patients with irritable bowel syndrome: A prospective study. (2018)
  • Author(s): Tanaka Y, Kanazawa M, Palsson OS, Van Tilburg MA, Gangarosa LM, Fukudo S, Drossman DA, Whitehead WE.
  • Journal Title: J Neurogastroenterol Motil Volume: 24 Issue: 1 Pages: 87-95
  • DOI: 10.5056/jnm16216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 特集 腸内細菌と臨床 1 .腸内細菌と消化器疾患(3)腸内細菌と便通異常･過敏性腸症候群 (2017)
  • Author(s): 金澤素、福土審．
  • Journal Title: 臨床消化器内科 Volume: 32 Issue: 10 Pages: 1325-1333
  • DOI: 10.19020/CG.0000000099
  • ISSN: 0911-601X, 2433-2488
  • Year and Date: 2017-08-20
• [Journal Article] Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome. (2017)
  • Author(s): Kano M, Muratsubaki T, Van Oudenhove L, Morishita J, Yoshizawa M, Kohno K, Yagihashi M, Tanaka Y, Mugikura S, Dupont P, Ly HG, Takase K, Kanazawa M, Fukudo S.
  • Journal Title: Sci Rep Volume: 29 Issue: 1 Pages: 12425-12425
  • DOI: 10.1038/s41598-017-09635-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 機能性ディスペプシア診療の新展開． (2017)
  • Author(s): 福土審、庄司知隆、金澤素．
  • Journal Title: Mebio Volume: 34 Pages: 49-56
• [Journal Article] Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): a large population-based Internet survey in Japan. (2016)
  • Author(s): Kanazawa M, Miwa H, Nakagawa A, Kosako M, Akiho H, Fukudo S.
  • Journal Title: Biopsychosoc Med Volume: 10 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s13030-016-0070-8
  • NAID: 130005399426
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differential activation in amygdala and plasma noradrenaline during colorectal distention by administration of corticotropin-releasing hormone between healthy individuals and patients with irritable bowel syndrome. (2016)
  • Author(s): Tanaka Y, Kanazawa M, Kano M, Morishita J, Hamaguchi T, Van Oudenhove L, Ly HG, Dupont P, Tack J, Yamaguchi T, Yanai K, Tashiro M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: 1-13
  • DOI: 10.1371/journal.pone.0157347
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. (2016)
  • Author(s): Komuro H, Sato N, Sasaki A, Suzuki N, Kano M, Tanaka Y, Yamaguchi-Kabata Y, Kanazawa M, Warita H, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: e0147817-e0147817
  • DOI: 10.1371/journal.pone.0147817
  • Peer Reviewed / Open Access
• [Journal Article] Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. (2016)
  • Author(s): Sasaki A, Sato N, Suzuki N, Kano M, Tanaka Y, Kanazawa M, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149322-e0149322
  • DOI: 10.1371/journal.pone.0149322
  • Peer Reviewed / Open Access
• [Journal Article] 過敏性腸症候群における腸内細菌． (2016)
  • Author(s): 金澤素、福土審．
  • Journal Title: Current Therapy Volume: 34 Pages: 1065-1071
• [Presentation] 湘南シンポジウムI：「IBS（過敏性腸症候群）」 過敏性腸症候群の病態に果たす腸内細菌の役割 (2020)
  • Author(s): 金澤素，福土審.
  • Organizer: 第47回日本潰瘍学会・第21回日本神経消化器病学会
  • Invited
• [Presentation] マウス間での腸内細菌移植によるneuron のIBS 様変化 (2020)
  • Author(s): 東航輝, 鈴木宏幸, 真砂拓海, 津島博道, 小西信一, 村椿智彦, 金澤素, 福土審.
  • Organizer: 第90 回日本心身医学会東北地方会
• [Presentation] アレキシサイミアにおける連続フラッシュ抑制下の表情知覚特性と半球機能差 (2020)
  • Author(s): 高橋玲央、鹿野理子、村椿智彦、金澤素、齋藤五大、行場次朗、福土審.
  • Organizer: 第90 回日本心身医学会東北地方会
• [Presentation] Metabolic alterations to fecal gut microbiota in patients with irritable bowel syndrome. (2019)
  • Author(s): Kanazawa M, Miyamoto K, Oka K, Takahashi M, Kano M, Fukudo S.
  • Organizer: The 120th Annual Meeting of American Gastroenterological Association (DDW2019)
  • Int'l Joint Research
• [Presentation] Altered gender difference in brain histamine H1 receptor binding in patients with irritable bowel syndrome: A positron emission tomography study. (2019)
  • Author(s): Morishita J, Shidahara M, Shoji T, Endo Y, Sato Y, Kano M, Kanazawa M, Tashiro M, Yanai K, Fukudo S.
  • Organizer: The 120th Annual Meeting of American Gastroenterological Association (DDW2019)
  • Int'l Joint Research
• [Presentation] Visceral Sensitivity Associated With Alexithymia in Patients with Irritable Bowel Syndrome. (2019)
  • Author(s): Kano M, Yagihashi M, Muratsubaki T, Kanazawa M, Fukudo S.
  • Organizer: 77th Annual Scientific Meeting of American Psychosomatic Meeting
  • Int'l Joint Research
• [Presentation] ワークショップ22：「下部機能性消化管障害の診療と研究の進歩」 過敏性腸症候群における便中腸内細菌叢の代謝機能プロファイリングの変化 (2019)
  • Author(s): 金澤素，鹿野理子，福土審.
  • Organizer: 第61回日本消化器病学会大会 (JDDW2019)
• [Presentation] 就労者に対するマインドフルネス介入の維持効果 (2019)
  • Author(s): 村椿智彦, 山田晶子, 鹿野理子, 金澤素, 井上ウィマラ, 福土審.
  • Organizer: 第2回日本心身医学関連学会合同集会
• [Presentation] 視床下部室傍核（PVN）における大腸伸展刺激の影響 (2019)
  • Author(s): 津島博道, Zhang Yanli, 田中由佳里, 金澤素, 福土審.
  • Organizer: 第2回日本心身医学関連学会合同集会
• [Presentation] シンポジウム8「迷走神経求心路と自律機能」. マインドフルネス心理療法による消化器症状，自律神経系への影響 (2019)
  • Author(s): 村椿智彦, 相澤祐一, 金澤素, 福土審.
  • Organizer: 第72回自律神経学会総会
  • Invited
• [Presentation] 過敏性腸症候群における破局的思考・抑うつによる消化器関連不安への影響 (2019)
  • Author(s): 山田晶子、西田健、村椿智彦、鹿野理子、金澤素、福土審.
  • Organizer: 第89回日本心身医学会東北地方会
• [Presentation] 過敏性腸症候群に対する簡易マインドフルネス瞑想の効果. (2019)
  • Author(s): 村椿智彦, 西村尭幸, 相澤祐一, 鹿野理子, 金澤素, 福土審.
  • Organizer: 第3回機能性腸疾患研究会
• [Presentation] マインドフルネスプログラムによる自覚ストレス，業務パフォーマンスへの効果. (2019)
  • Author(s): 村椿智彦, 山田晶子, 鹿野理子, 金澤素, 井上ウィマラ, 福土審.
  • Organizer: 第88回日本心身医学会東北地方会
• [Presentation] 過敏性腸症候群における脳波異常，腹部症状への簡易マインドフルネス瞑想の効果. (2019)
  • Author(s): 村椿智彦, 西村尭幸, 相澤祐一, 鹿野理子, 金澤素, 福土審.
  • Organizer: 第88回日本心身医学会東北地方会
• [Presentation] Fecal FKBP-type peptidylprolyl cis-trans isomerases are promoted by treatment of a protease inhibitor in patients with irritable bowel syndrome. (2018)
  • Author(s): Kanazawa M, Miyamoto K, Oka K, Takahashi M, Kano M, Fukudo S.
  • Organizer: The 119th Annual Meeting of American Gastroenterological Association (DDW2018)
  • Int'l Joint Research
• [Presentation] Effects of corticotropin-releasing hormone receptor 1 antagonist on colonic sensorimotor dysfunction and emotional responses in rats. (2018)
  • Author(s): Zhang Y, Tsuchiya E, Tsushima H, Muratsubaki T, Kanazawa M, Fukudo S.
  • Organizer: The 119th Annual Meeting of American Gastroenterological Association (DDW2018)
  • Int'l Joint Research
• [Presentation] Kiwifruit can reduce whole gut transit and symptoms in patients with functional constipation and patients with irritable bowel syndrome with constipation. (2018)
  • Author(s): Okawa Y, Nakaya K, Muratsubaki T, Okamoto T, Fuda M, Endo Y, Kano M, Kanazawa M, Nakaya N, Barbara G, Gearry R, Ansell J, Kuhn-Sherlock B, Drummond L, Fukudo S.
  • Organizer: The 119th Annual Meeting of American Gastroenterological Association (DDW2018)
  • Int'l Joint Research
• [Presentation] What is the best medical treatment for irritable bowel syndrome (IBS)? A cross-cultural comparison study between Japan and the US. (2018)
  • Author(s): Kanazawa M, Palsson OS, Whitehead WE, Fukudo S.
  • Organizer: The 18th Congress of the Asian College of Psychosomatic Medicine (ACPM2018)
  • Int'l Joint Research / Invited
• [Presentation] The relevant varies of physical activity by executing exercises in IBS. (2018)
  • Author(s): Hamaguchi T, Tayama T, Saigou T, Tomiie T, Kanazawa M, Fukudo S.
  • Organizer: The 18th Congress of the Asian College of Psychosomatic Medicine (ACPM2018)
  • Int'l Joint Research / Invited
• [Presentation] 過敏性腸症候群の消化管運動機能異常． (2018)
  • Author(s): 金澤素，福土審．
  • Organizer: 第60回日本平滑筋学会総会
  • Invited
• [Presentation] 機能性腸疾患における腸内細菌研究の進歩． (2018)
  • Author(s): 金澤素、福土審．
  • Organizer: 第20回日本神経消化器病学会
  • Invited
• [Presentation] 過敏性腸症候群患者におけるメシル酸カモスタットによる便中腸内細菌叢の機能遺伝子に対する効果． (2018)
  • Author(s): 金澤素、宮本健太郎、岡健太郎、高橋志達、鹿野理子、福土審．
  • Organizer: 第59回日本心身医学会総会
• [Presentation] 機能性消化管疾患群における便通異常に対するkiwifruitの有効性の検証． (2018)
  • Author(s): 大川洋平、中谷久美、村椿智彦、岡本智子、布田美貴子、遠藤由香、鹿野理子、金澤素、中谷直樹、Giovanni Barbara、Richard Gearry、Juliet Ansell、Barbara Kuhn-Sherlock、Lynley Drummond、福土審．
  • Organizer: 第59回日本心身医学会総会
• [Presentation] 非侵害性大腸伸展刺激は拘束ストレスによる脳内CRHニューロン活性化を抑制する． (2018)
  • Author(s): 津島博道、Yanli Zhang、田中由佳里、金澤素、福土審．
  • Organizer: 第20回日本神経消化器病学会
• [Presentation] 就労者におけるストレス低減と生産性向上を目的としたマインドフルネス介入の有効性：無作為化比較試験. (2018)
  • Author(s): 村椿智彦, 山田晶子, 鹿野理子, 金澤素, 井上ウィマラ, 福土審.
  • Organizer: 日本マインドフルネス学会第5回大会
• [Presentation] 非侵害性大腸伸展刺激は拘束ストレスによる脳内神経活性化を抑制する． (2018)
  • Author(s): 津島博道、Yanli Zhang、田中由佳里、金澤素、福土審．
  • Organizer: 第87回日本心身医学会東北地方会
• [Presentation] 過敏性腸症候群における腸内細菌叢、脳形態ならびに心理傾向の関連． (2018)
  • Author(s): 山田晶子、西田健、村椿智彦、鹿野理子、金澤素、黒木靖敏、岡健太郎、高橋志達、福土審．
  • Organizer: 第87回日本心身医学会東北地方会
• [Presentation] 過敏性腸症候群の病態に果たす腸内細菌の役割． (2018)
  • Author(s): 金澤 素、福土 審．
  • Organizer: 第14回日本消化管学会総会
  • Invited
• [Presentation] 機能性消化管疾患群における便通異常ならびに消化管通過に対するkiwifruitとpsylliumの比較検証試験． (2018)
  • Author(s): 大川洋平、中谷久美、村椿智彦、岡本智子、布田美貴子、遠藤由香、鹿野理子、金澤素、中谷直樹、Barbara G、Gearry R、Ansell J、Kuhn-Sherlock B、Drummond L、福土審．
  • Organizer: 第86回日本心身医学会東北地方会
• [Presentation] 過敏性腸症候群の病態に寄与する便中腸内細菌叢の解明． (2018)
  • Author(s): 藤由彩香、真室奈青、金澤素、福土審．
  • Organizer: 第86回日本心身医学会東北地方会
• [Presentation] Aggravating factors of IBS. (2017)
  • Author(s): Kanazawa M, Fukudo S.
  • Organizer: ANMA & JSNM Joint Meeting 2017
  • Place of Presentation: Osaka, Osaka International Convention Center
  • Year and Date: 2017-03-23
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiology of abnormal intestinal motility in IBS. (2017)
  • Author(s): Kanazawa M, Fukudo S.
  • Organizer: ANMA & JSNM Joint Meeting 2017
  • Place of Presentation: Osaka, Osaka International Convention Center
  • Year and Date: 2017-03-23
  • Int'l Joint Research / Invited
• [Presentation] The relationship between gut microbiota and brain morphology in irritable bowel syndrome. (2017)
  • Author(s): Nishida K, Muratsubaki T, Yamada A, Kano M, Kanazawa M, Kuroki Y, Oka K, Takahashi M, Fukudo S.
  • Organizer: ANMA & JSNM Joint Meeting 2017
  • Place of Presentation: Osaka, Osaka International Convention Center
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Risk factors associated with irritable bowel syndrome with constipation: Further analyses using a large population-based Internet survey in Japan. (2017)
  • Author(s): Kondo R, Kanno Y, Aoto K, Muratsubaki T, Kanazawa M, Fukudo S.
  • Organizer: ANMA & JSNM Joint Meeting 2017
  • Place of Presentation: Osaka, Osaka International Convention Center
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Increase in visceral pain sensitivity to colorectal distention after peripheral administration of corticotropin-releasing hormone in patients with irritable bowel syndrome. (2017)
  • Author(s): Kanazawa M, Kano M, Muratsubaki T, Yagihashi M, Fukudo S.
  • Organizer: The 118th Annual Meeting of American Gastroenterological Association (DDW2017)
  • Int'l Joint Research
• [Presentation] 過敏性腸症候群における消化管運動機能異常． (2017)
  • Author(s): 金澤素、福土審．
  • Organizer: 第54回日本臨床生理学会総会
  • Invited
• [Presentation] 過敏性腸症候群患者における corticotropin-releasing hormone 負荷後の直腸伸展刺激に対する内臓知覚過敏性． (2017)
  • Author(s): 金澤素、鹿野理子、村椿智彦、八木橋真央、福土審．
  • Organizer: 第58回日本心身医学会総会
• [Presentation] 過敏性腸症候群の病態に対する中枢性鎮痛法の開発：ドパミン系の関与． (2017)
  • Author(s): 福土審、金澤素、田代学．
  • Organizer: 第103回日本消化器病学会総会
  • Invited
• [Presentation] 東北メディカル・メガバンクにおける過敏性腸症候群の有病割合：地域住民コホート調査． (2017)
  • Author(s): 永家聖、中谷直樹、田中由佳里、金澤素、荻島創一、高井貴子、中村智洋、土屋菜歩、成田暁、栗山進一、田中博、辻一郎、呉繁夫、寳澤篤、福土審．
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] Effects of corticotropin-releasing hormone receptor 1 antagonist on colonic motor and emotional responses in rats. (2017)
  • Author(s): Zhang Yanli、土屋恵美子、津島博道、村椿智彦、金澤素、福土審．
  • Organizer: 第85回日本心身医学会東北地方会
• [Presentation] 症状特異的不安とマインドフルネス傾向がIBS症状に及ぼす影響． (2017)
  • Author(s): 山田晶子、西田健、村椿智彦、鹿野理子、金澤素、福土審．
  • Organizer: 第85回日本心身医学会東北地方会
• [Presentation] Visceral hypersensitivity in irritable bowel syndrome. (2016)
  • Author(s): Kanazawa M, Fukudo S.
  • Organizer: 第21回日本心療内科学会総会
  • Place of Presentation: 奈良、奈良春日野国際フォーラム
  • Year and Date: 2016-12-03
  • Invited
• [Presentation] 消化管バロスタット検査の原理と評価法． (2016)
  • Author(s): 金澤素、福土審．
  • Organizer: 第69回日本自律神経学会総会
  • Place of Presentation: 熊本、くまもと県民交流館パレア
  • Year and Date: 2016-11-10
  • Invited
• [Presentation] 肥満症患者におけるマインドフルネス特性と心理行動的要因の関連. (2016)
  • Author(s): 村椿智彦、鹿野理子、石垣泰、澤田正二郎、近藤敬一、佐々木彩加、森下城、金澤素、片桐秀樹、福土審.
  • Organizer: 日本マインドフルネス学会第3回大会
  • Place of Presentation: 東京、早稲田大学国際会議場
  • Year and Date: 2016-11-05
• [Presentation] Dysfunction of peripheral and central corticotropin-releasing hormonal (CRH) system in patients with irritable bowel syndrome (IBS). (2016)
  • Author(s): Kano M, Muratsubaki T, Morishita J, M Yagihashi, Ly HG, Dupont P, Van Oudenhove L, Kanazawa M, Fukudo S.
  • Organizer: The 16th World Congress on Pain
  • Place of Presentation: Yokohama, Pacifico Yokohama
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] The influence of alexithymia on hypothalamic-pituitary-adrenal axis reaction in irritable bowel syndrome. (2016)
  • Author(s): Yagihashi M, Kano, M, Muratsubaki T, Kanazawa M, Morishita J, Tanaka Y, Fukudo S.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Pacifico Yokohama
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Association between brain activity in the mPFC during rectal distention and ACTH response in irritable bowel syndrome. (2016)
  • Author(s): Kano M, Muratsubaki T, Morishita J, Yagihashi M, Ly HG, Dupont P, Van Oudenhove L, Kanazawa M, Fukudo S.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-07-20
• [Presentation] 過敏性腸症候群における腸内細菌叢異常に対するメシル酸カモスタットの効果. (2016)
  • Author(s): 金澤素、宮本健太郎、岡健太郎、高橋志達、鹿野理子、福土審．
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
  • Invited
• [Presentation] 肥満症患者の灰白質容量とBMI，糖代謝指標との関係． (2016)
  • Author(s): 村椿智彦、鹿野理子、石垣泰、関口敦、澤田正二郎、近藤敬一、事崎由佳、佐々木彩加、森下城、金澤素、片桐秀樹、川島隆太、福土審．
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] 機能性ディスペプシアにおけるクロロゲン酸コーヒー飲料のディスペプシア症状および消化管ホルモンへの影響． (2016)
  • Author(s): 矢神里沙、庄司知隆、中谷直樹、中村智洋、遠藤由香、佐藤康弘、町田知美、町田貴胤、鹿野理子、金澤素、中谷久美、村椿智彦、相澤祐一、小室葉月、佐々木彩加、竹下尚男、水野智仁、渡辺卓也、福土審.
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] 大腸伸展刺激による副腎皮質刺激ホルモン(ACTH) 反応はACTH放出ホルモン投与時のACTH反応を規定する． (2016)
  • Author(s): 八木橋真央、鹿野理子、村椿智彦、金澤素、森下城、田中由佳里、福土審.
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] メタボローム解析による過敏性腸症候群の不安・抑うつとトリプトファン代謝物の関連性について. (2016)
  • Author(s): 菅井千奈美、金澤素、田中由佳里、村椿智彦、森下城、鹿野理子、庄司知隆、遠藤由香、福土審.
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] 日本語版Brief Symptom Inventory 18の因子構造の検討. (2016)
  • Author(s): 篠崎雅江、金澤素、Palsson OS、相模泰弘、遠藤由香、本郷道夫、Drossman DA、Whitehead WE、福土審.
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] 過敏性腸症候群における2D：4D比と病型の関係． (2016)
  • Author(s): 佐藤瑞季、村椿智彦、松生香里、鹿野理子、金澤素、福土審．
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] コルチコトロピン放出ホルモン受容体1、2遺伝子における一塩基多型と過敏性腸症候群との関連． (2016)
  • Author(s): 小室葉月、佐藤菜保子、佐々木彩加、鈴木直輝、鹿野理子、田中由佳里、山口由美、金澤素、割田仁、青木正志、福土審.
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台、仙台国際センター
  • Year and Date: 2016-06-04
• [Presentation] A protease inhibitor modifies altered composition of gut microbial communities in patients with irritable bowel syndrome. (2016)
  • Author(s): Kanazawa M, Miyamoto K, Oka K, Takahashi M, Kano M, Fukudo S.
  • Organizer: The 117th Annual Meeting of American Gastroenterological Association (DDW2016)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Abdominal bloating is the most bothersome symptom in irritable bowel syndrome with constipation (IBS-C): A large population-based Internet survey in Japan. (2016)
  • Author(s): Kanazawa M, Miwa H, Nakagawa A, Kosako M, Akiho H, Fukudo S.
  • Organizer: The 117th Annual Meeting of American Gastroenterological Association (DDW2016)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Effect of hydroxyhydroquinone-reduced and chlorogenic acids-rich vs usual coffee on symptoms and glucagon-like peptide-1 in patients with functional dyspepsia. (2016)
  • Author(s): Yagami R, Shoji T, Nakaya N, Nakamura T, Endo Y, Sato Y, Machida T, Machida T, Kano M, Kanazawa M, Nakaya K, Muratsubaki T, Aizawa Y, Komuro H, Sasaki A, Takeshita M, Mizuno T, Watanabe T, Fukudo S.
  • Organizer: The 117th Annual Meeting of American Gastroenterological Association (DDW2016)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] 過敏性腸症候群の腸内細菌叢の解析． (2016)
  • Author(s): 金澤素、鹿野理子、福土審．
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2016-04-21
  • Invited
• [Book] 神経・精神疾患による消化管障害ベッドサイドマニュアル (2019)
  • Author(s): 金澤素、福土審．
  • Total Pages: 379
  • Publisher: 中外医学社
  • ISBN: 9784498140486