The association of psychosocial factors, family functions and social brain with dementia in a general population: the Hisayama study.

• Project/Area Number: 16K09244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kyushu University
• Principal Investigator: Shibata Mao 九州大学, 医学研究院, 助教 (20734982)
• Co-Investigator(Kenkyū-buntansha): 二宮 利治 九州大学, 医学研究院, 教授 (30571765) ; 細井 昌子 九州大学, 大学病院, 講師 (80380400) ; 小原 知之 九州大学, 医学研究院, 助教 (20623630)
• Research Collaborator: HIRABAYASHI naoki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 認知症 / 孤独感 / 高齢者 / 疫学研究 / 地域一般住民 / 心理社会的因子 / 家族 / BPSD / 頭部MRI画像 / 慢性疼痛 / 失感情症 / 久山町研究 / 心身医学 / 予防疫学

Outline of Final Research Achievements

We investigated the prospective association between social and emotional loneliness, due to lack of social contact and emotional attachment respectively, and incident dementia. In total, 952 Japanese community-residents aged 65 and older without dementia were followed prospectively from when they evaluated their loneliness in 2012 to 2017. The age- and sex- adjusted odds ratio for dementia with emotional loneliness was significantly higher in subjects with emotional loneliness than those without (2.08 [p <0.01]). This significant association was observed even after multivariate adjustment. Emotional loneliness was significantly associated with the risk of developing dementia in a community-based elderly.

Academic Significance and Societal Importance of the Research Achievements

孤独感と認知症の関係を示唆する報告が散見されているが、地域高齢者において社会的接触の欠如に起因する社会的孤独感と、情緒的愛着の不足に起因する情緒的孤独感を分けて、認知症発症との関連を縦断的に検討した報告は知る限りなく、本研究が初めての報告である。認知症の予防や認知症高齢者のケアにおいて、情緒的孤独感を考慮することの重要性が示唆された。また、本研究で収集した65歳以上の高齢者およびその40歳以上の同居家族を含む2684名の心理社会的因子と認知症発症の関連を解析することで、認知症予防および認知症周辺症状の進行抑制に有効な心理社会的因子の同定に寄与すると考えられる。

Research Products

• [Journal Article] Association of daily sleep duration with the risk of dementia and mortality in a Japanese community (2018)
  • Author(s): Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
  • Journal Title: Journal of the American Geriatrics Society Volume: in press Issue: 10 Pages: 1911-1918
  • DOI: 10.1111/jgs.15446
  • Peer Reviewed / Open Access
• [Journal Article] Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study (2018)
  • Author(s): Ohara Tomoyuki、Hata Jun、Tanaka Masashi、Honda Takanori、Yamakage Hajime、Yoshida Daigo、Inoue Takayuki、Hirakawa Yoichiro、Kusakabe Toru、Shibata Mao、Teraoka Tadashi、Kitazono Takanari、Kanba Shigenobu、Satoh-Asahara Noriko、Ninomiya Toshiharu
  • Journal Title: Annals of Neurology Volume: 85 Issue: 1 Pages: 47-58
  • DOI: 10.1002/ana.25385
  • Peer Reviewed / Open Access
• [Journal Article] Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study. (2018)
  • Author(s): Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: J Am Heart Assoc Volume: 7 Issue: 2
  • DOI: 10.1161/jaha.117.006693
  • Peer Reviewed / Open Access
• [Journal Article] Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. (2017)
  • Author(s): Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circulation Volume: 136 Issue: 6 Pages: 516-525
  • DOI: 10.1161/circulationaha.116.025667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study (2016)
  • Author(s): Shibata M, Ninomiya T, Anno K , Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M
  • Journal Title: BMC Psychiatry Volume: 7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: the Hisayama Study. (2016)
  • Author(s): Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Journal Title: Diabetes Care Volume: 39 Pages: 1543-1549
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 地域高齢住民における血清エライジン酸濃度と認知症発症の関連：久山町研究． (2019)
  • Author(s): 本田貴紀、小原知之、篠原正和、秦 淳、杜 隆嗣、吉田大悟、石田達郎、平川洋一郎、入野康宏、柴田舞欧、坂田智子、神庭重信、平田健一、二宮利治
  • Organizer: 第29回日本疫学会学術総会
• [Presentation] The association between progression of dementia and loneliness in an older general population from the viewpoint of sociak and emotional aspects: the Hisayama Study. (2018)
  • Author(s): Shibata M, Hosoi M, Ohara T, Hirabayashi N, Anno K, Yoshida D, Kanba S, Sudo N, Ninomiya T
  • Organizer: The 18th Congress of the Asian College of Psychosomatic Medicine
  • Int'l Joint Research
• [Presentation] Serum NT-proBNP level is A useful biomarker for future dementia in a general Japanese elderly population: the Hisayama Study. (2018)
  • Author(s): Nagata T, Ohara T, Honda T, Sakata S, Hata J, Hirakawa Y, Yoshida D, Shibata M, Ide T, Tsutsui H, Ninomiya T
  • Organizer: AHA Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] βアラニン血中濃度と認知症発症の関連：久山町研究． (2018)
  • Author(s): 秦 淳、小原知之、片倉喜範、清水邦義、山下俊太郎、吉田大悟、本田貴紀、平川洋一郎、柴田舞欧、坂田智子、北園孝成、久原 哲、二宮利治
  • Organizer: 第25回日本未病システム学会学術総会
• [Presentation] 地域高齢者における中年期から老年期の握力低下と認知症発症の関連：久山町研究． (2018)
  • Author(s): 畑部暢三、柴田舞欧、小原知之、大石絵美、吉田大悟、本田貴紀、秦 淳、神庭重信、北園孝成、二宮利治
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学大会合同年会
• [Presentation] 家庭血圧の日間変動と認知症との関連：久山町研究． (2018)
  • Author(s): 大石絵美、小原知之、坂田智子、福原正代、秦 淳、吉田大悟、柴田舞欧、大坪俊夫、北園孝成、清原 裕、二宮利治
  • Organizer: 第41回日本高血圧学会総会
• [Presentation] 幼少期からの慢性疼痛予防：養育スタイルと家族機能の観点から． (2018)
  • Author(s): 細井昌子，柴田舞欧，安野広三，早木千絵，岩城理恵，富岡光直，須藤信行
  • Organizer: 第47回日本慢性疼痛学会
• [Presentation] ケアが少なく過干渉な被養育体験は成人後の慢性疼痛の重症度に関連する：症例対照研究 (2017)
  • Author(s): 柴田舞欧，二宮利治，安野広三，河田浩，岩城理恵，富岡光直，久保千春，須藤信行, 細井昌子
  • Organizer: 第46回日本慢性疼痛学会
• [Presentation] 地域高齢者における認知症と孤独感の関連：久山町研究． (2017)
  • Author(s): 柴田舞欧，小原知之，細井昌子，吉田大悟，平林直樹，安野広三，須藤信行，神庭重信，二宮利治
  • Organizer: 日本臨床疫学会第1回年次学術大会
• [Presentation] 地域高齢者における中年期から老年期までの握力変化と認知症発症の関連：久山町研究． (2017)
  • Author(s): 畑部暢三，柴田舞欧，小原知之，大石絵美，岸本裕歩，本田貴紀，吉田大悟，秦 淳，神庭重信，二宮利治
  • Organizer: 第24回日本未病システム学会学術総会
• [Presentation] 幼少期の被養育体験は成人後の睡眠障害に関連する：久山町研究． (2016)
  • Author(s): 柴田舞欧、細井昌子、安野広三、河田 浩、岩城理恵、澤本良子、久保千春、須藤信行、清原 裕、二宮利治
  • Organizer: 第23回日本未病システム学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-11-05
• [Presentation] Elevated 2-hour post-load glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study. (2016)
  • Author(s): Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Goto S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Organizer: Announcing the American Diabetes Association's 76th Scientific Sessions.
  • Place of Presentation: Louisiana
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] 地域高齢者における認知症と孤独感の関連：久山町研究． (2016)
  • Author(s): 柴田舞欧、細井昌子、平林直樹、安野広三、須藤信行、清原 裕、二宮利治
  • Organizer: 第57回日本心身医学会総会ならびに学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2016-06-04
• [Remarks] 九州大学大学院医学研究院 衛生・公衆衛生学分野
  • URL: http://www.eph.med.kyushu-u.ac.jp/result/
• [Remarks] 健康長寿社会の実現を目指した大規模認知症コホート研究
  • URL: https://www.eph.med.kyushu-u.ac.jp/jpsc/results/?c=20