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Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of esohageal fibrosis after endoscopic submucosal dissection

Research Project

Project/Area Number 16K09280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

Satoru Hashimoto  新潟大学, 医歯学総合研究科, 特任准教授 (10768667)

Co-Investigator(Kenkyū-buntansha) 寺井 崇二  新潟大学, 医歯学系, 教授 (00332809)
佐藤 祐一  新潟大学, 医歯学総合研究科, 客員研究員 (00401761)
上村 顕也  新潟大学, 医歯学総合病院, 講師 (00579146)
佐藤 裕樹  新潟大学, 医歯学総合病院, 特任助教 (50644556)
土屋 淳紀  新潟大学, 医歯学総合病院, 講師 (70464005)
Research Collaborator TABATA yasuhiko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords食道癌 / 食道狭窄 / 内視鏡的粘膜下層剥離術 / トリアムシノロン / ハイドロゲルシート / 徐放化 / 早期食道癌 / 生体吸収性ゼラチンハイドロゲルシート / ハイドロゲル
Outline of Final Research Achievements

Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. TA was suspended in biodegradable gelatin and freeze-dried in a sheet form. In this study, we prepared a TA suspension gelatin sheet (TA sheet) and confirmed both the homogeneity of suspended TA and controlled-release of TA in the presence of collagenase in vitro. The TA sheet decreased the rate of skin wound regeneration and caused less myofibroblast infiltration into the tissue than the control sheet did. In addition, the TA sheet caused less myofibroblast infiltration into the tissue than TA injection.

Academic Significance and Societal Importance of the Research Achievements

今回作製したトリアムシノロン内包化ゼラチンシートは、薬剤徐放性、線維化抑制効果を認めた。皮膚瘢痕拘縮、関節可動制限、消化管領域では食道狭窄など、線維化をきたす疾患に関しては、このシートによって改善が見込まれる可能性がある。シート自体はゼラチンを使用し、人体に無害であるため、臨床応用の可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for2019

    • Author(s)
      Nao Nakajima, Satoru Hashimoto, Hiroki Sato, Kazuya Takahashi, Takuro Nagoya, Kenya Kamimura, Atsunori Tsuchiya, Junji Yokoyama, Yuichi Sato, Hanako Wakatsuki, Masayuki Miyata, Yusuke Akashi, Ryusuke Tanaka, Ken Matsuda, Yasuhiko Tabata, Shuji Terai
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 41-46

    • DOI

      10.1016/j.reth.2019.04.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Anti-fibrotic efficacy of gelatin sheet containing triamcinolone acetonide2018

    • Author(s)
      Nao Nakajima, Satoru Hashimoto, Takuro Nagoya, Hiroki Sato, Kazuya Takahashi, Yusuke Akashi, Ryusuke Tanaka, Yasuhiko Tabata, Shuji Terai
    • Organizer
      TERMIS World Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] トリアムシノロンアセトニド内包化ゼラチンシートの効果の検証2018

    • Author(s)
      中島尚 橋本哲 寺井崇二
    • Organizer
      日本再生医療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] トリアムシノロンアセトニド内包化ゼラチンハイドロゲルシートの効果の検証2017

    • Author(s)
      中島 尚、 橋本 哲、 寺井 崇二
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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