| Project/Area Number |
16K09355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江口 暁子 三重大学, 医学系研究科, 特任講師(研究担当) (00598980)
白木 克哉 三重大学, 医学系研究科, 連携教授 (90263003)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脂肪肝 / 動脈硬化 / 血管平滑筋 / 肝臓学 |
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| Outline of Final Research Achievements |
Several epidemiologic studies have shown NAFLD has close relation to atherosclerosis, however, whether steatotic liver cells can directly induce atherosclerosis is not clear yet. In this study, we showed extracellular vesicles (EV) derived from steatotic liver cells enhanced the gene expressions related inflammation, apoptosis and cell motility of arterial smooth muscle cells, and also enhanced cell migration of these cells. These data indicate steatotic liver cells play an important role in the generation of atherosclerosis by releasing EV.
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| Academic Significance and Societal Importance of the Research Achievements |
NAFLD患者では健常者に比べて死亡率が高く、その死因の第一位は心血管イベントであることが知られているが、これまで脂肪化肝細胞と動脈硬化の直接的な関連は示されていなかった。今回の研究は脂肪化肝細胞が細胞外小胞を介して血管平滑筋に働きかけ動脈硬化病巣を形成することが示された。この機序を抑制することでNAFLDにおける動脈硬化を抑制し、死亡率を下げる可能性が示唆された。
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