G0S2 in liver regulates insulin sensitivity

• Project/Area Number: 16K09363
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Juntendo University
• Principal Investigator: SATOH HIROAKI 順天堂大学, 医学部, 先任准教授 (20323595)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脂肪肝 / インスリン抵抗性 / 糖尿病 / G0S2 / 内科

Outline of Final Research Achievements

We investigated the effects of hepatic G0S2 on insulin sensitivity in male Wistar rats receiving a normal chow diet (NCD) or a high-fat diet (HFD). In the HFD-fed rats, during the clamp study, the glucose infusion rate required for euglycemia significantly decreased by 16% in the Ad-G0S2 group compared with the Ad-GFP group. The insulin-suppressed hepatic glucose output significantly increased in the Ad-G0S2 group. Moreover, Oil Red O-staining indicated that overexpression of G0S2 protein in the liver promoted hepatic steatosis by 2.5-fold in the HFD-fed rats. However, Masson’s trichrome staining revealed that overexpression of G0S2 significantly ameliorated fibrosis in the livers of the HFD-fed rats. Consistent with histological data, the expression of TGF-b and Smad2 were significantly decreased in livers of the HFD-fed rats.
These results indicate that hepatic G0S2 protein might promote hepatic insulin resistance by exacerbating hepatic steatosis, but ameliorating hepatic fibrosis.

Academic Significance and Societal Importance of the Research Achievements

本研究では、肝臓でのG0S2蛋白発現が脂肪肝の進展に関与し、肝臓でのインスリン抵抗性の増悪因子としての役割を果たすことを明らかにした。
本研究の成果により、肝臓におけるG0S2蛋白と脂肪肝・インスリン抵抗性との関連が解明され、インスリン抵抗性の新たな発症機序の解明につながると期待される。さらに今後ますます重要と考えられるインスリン抵抗性の治療薬の開発につながると期待される。

Research Products

• [Journal Article] New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population (2019)
  • Author(s): Hirai Hiroyuki、Asahi Koichi、Yamaguchi Satoshi、Mori Hirotaka、Satoh Hiroaki、Iseki Kunitoshi、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2813-2813
  • DOI: 10.1038/s41598-019-39049-w
  • Peer Reviewed / Open Access
• [Journal Article] Effects of linagliptin versus voglibose on treatment-related quality of life in patients with type 2 diabetes: sub-analysis of the L-STEP study (2018)
  • Author(s): Goto, H., Mita, T., Fujitani, Y., Fujimoto, S., Takahashi, K., Satoh, H., Hirose, T., Hiyoshi, T., Ai, M., Okada, Y., Nishimura, H., Kuroda, H., Matsubara, T., Gosho, M., Ishii, H.,Watada, H
  • Journal Title: Endocrine Journal Volume: 65 Issue: 6 Pages: 657-668
  • DOI: 10.1507/endocrj.EJ18-0088
  • NAID: 130007411684
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Effects of linagliptin monotherapy compared with voglibose on postprandial lipid profiles in Japanese patients with type 2 diabetes: linagliptin study of effects on postprandial blood glucose (L-STEP) sub-study 1 (2018)
  • Author(s): Kurozumi, A., Okada, Y., Satoh, H., Inoue, I., Chimori, H., Akita, E., Shiraiwa, T., Fujitani, Y., Mita, T., Gosho, M.,Watada, H
  • Journal Title: Endocrine Journal Volume: 65 Issue: 4 Pages: 415-425
  • DOI: 10.1507/endocrj.EJ17-0386
  • NAID: 130006727068
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes (2018)
  • Author(s): Oshima Megumi、Toyama Tadashi、Haneda Masakazu、Furuichi Kengo、Babazono Tetsuya、Yokoyama Hiroki、Iseki Kunitoshi、Araki Shinichi、Ninomiya Toshiharu、Hara Shigeko、Nakamura Hiroyuki、Shimizu Miho、Hara Akinori、Makino Hirofumi、Wada Takashi et al.
  • Journal Title: PLOS ONE Volume: 13 Issue: 8 Pages: e0201535-e0201535
  • DOI: 10.1371/journal.pone.0201535
  • Peer Reviewed / Open Access
• [Journal Article] Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population (2018)
  • Author(s): Ogata Emi、Asahi Koichi、Yamaguchi Satoshi、Iseki Kunitoshi、Sato Hiroaki、Moriyama Toshiki、Yamagata Kunihiro、Tsuruya Kazuhiko、Fujimoto Shouichi、Narita Ichiei、Konta Tsuneo、Kondo Masahide、Shibagaki Yugo、Kasahara Masato、Watanabe Tsuyoshi、Shimabukuro Michio
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 13927-13927
  • DOI: 10.1038/s41598-018-31744-4
  • Peer Reviewed / Open Access
• [Journal Article] Preliminary Evidence for Adipocytokine Signals in Skeletal Muscle Glucose Uptake (2018)
  • Author(s): Kudoh A, Satoh H, Hirai H, Watanabe T, Shimabukuro M
  • Journal Title: Front Endocrinol (Lausanne) Volume: 9 Pages: 295-295
  • DOI: 10.3389/fendo.2018.00295
  • Open Access
• [Journal Article] Pleiotropic effects of SGLT2 inhibitors beyond the effect on glycemic control (2018)
  • Author(s): Satoh H
  • Journal Title: Diabetology International Volume: 9 Issue: 4 Pages: 212-214
  • DOI: 10.1007/s13340-018-0367-x
  • NAID: 40021687125
  • Peer Reviewed
• [Journal Article] Effects of linagliptin vs. voglibose on daily glucose excursions during continuous glucose monitoring of Japanese type 2 diabetes patients (L-CGM): A randomized, open-label, two-arm, parallel comparative trial (2017)
  • Author(s): Satoh H, Ohira T, Moriya C, Inoue I, Kuribayashi S, Seino H, Hirai H, Hiyoshi T, Watada H
  • Journal Title: Diabetes Metab Volume: 43 Issue: 6 Pages: 550-553
  • DOI: 10.1016/j.diabet.2017.07.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Liver-specific G0/G1 switch gene 2 (G0s2) expression promotes hepatic insulin resistance by exacerbating hepatic steatosis in male Wistar rats (2017)
  • Author(s): Sugaya Y, Satoh H
  • Journal Title: J Diabetes Volume: 9 Issue: 8 Pages: 754-763
  • DOI: 10.1111/1753-0407.12482
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Kidney dysfunction following adrenalectomy in autosomal dominant polycystic kidney disease complicated with primary aldosteronism: A case report. (2017)
  • Author(s): Hirai H, Kanno M, Watanabe T, Satoh H
  • Journal Title: Exp Ther Med Volume: 14 Issue: 2 Pages: 1235-1240
  • DOI: 10.3892/etm.2017.4588
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey (2017)
  • Author(s): Takahashi A, Ohira T, Uemura M, Hosoya M, Yasumura S, Hashimoto, Ohira H, Sakai A, Ohtsuru A, Satoh H, Kawasaki Y, Suzuki H, Sugiura Y, Shishido H, Hayashi Y, Takahashi H, Nakano H, Kobashi G, Ozasa K, Ohto H, Abe M.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 776-776
  • DOI: 10.1038/s41598-017-00776-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey (2017)
  • Author(s): Takahashi A, Ohira T, Hosoya M, Yasumura S, Nagai M, Ohira H, Hashimoto S, Satoh H, Sakai A, Ohtsuru A, Kawasaki Y, Suzuki H, Kobashi G, Ozasa K, Yamashita S, Kamiya K, Abe M
  • Journal Title: Journal of Epidemiology Volume: 27 Issue: 4 Pages: 180-185
  • DOI: 10.1016/j.je.2016.05.006
  • NAID: 130005611978
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome (2017)
  • Author(s): Hashimoto S, Nagai M, Fukuma S, Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Kamiya K, Yamashita S, Fukuhara SI, Ohto H, Abe M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 3 Pages: 327-337
  • DOI: 10.5551/jat.35824
  • NAID: 130005397946
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The impact of evacuation on the incidence of chronic kidney disease after the Great East Japan Earthquake: The Fukushima Health Management Survey. (2017)
  • Author(s): Hayashi Y, Nagai M, Ohira T, Satoh H, Sakai A, Ohtsuru A, Hosoya M, Kawasaki Y, Suzuki H, Takahashi A, Sugiura Y, Shishido H, Takahashi H, Yasumura S, Kazama JJ, Hashimoto S, Kobashi G, Ozasa K, Abe M.
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  • DOI: 10.1007/s10157-017-1395-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Persistent prevalence of polycythemia among evacuees 4 years after the Great East Japan Earthquake: A follow-up study. (2017)
  • Author(s): Sakai A, Nakano H, Ohira T, Hosoya M, Yasumura S, Ohtsuru A, Satoh H, Kawasaki Y, Suzuki H, Takahashi A, Sugiura Y, Shishido H, Hayashi Y, Takahashi H, Kobashi G, Ozasa K, Hashimoto S, Ohto H, Abe M
  • Journal Title: Preventive Medicine Reports Volume: 5 Pages: 251-256
  • DOI: 10.1016/j.pmedr.2017.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evacuation is a risk factor for diabetes development among evacuees of the Great East Japan earthquake: A 4-year follow-up of the Fukushima Health Management Survey (2017)
  • Author(s): Satoh H, Ohira T, Nagai M, Hosoya M, Sakai A, Yasumura S, Ohtsuru A, Kawasaki Y, Suzuki H, Takahashi A, Sugiura Y, Shishido H, Hayashi Y, Takahashi H, Kobashi G, Ozasa K, Hashimoto S, Ohto H, Abe M, Kamiya K.
  • Journal Title: Diabetes & Metabolism Volume: 17 Issue: 3 Pages: 30517-30517
  • DOI: 10.1016/j.diabet.2017.09.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 血糖による炎症の臓器障害 (2017)
  • Author(s): 佐藤博亮，綿田裕孝
  • Journal Title: 尿酸と血糖 Volume: 3 Pages: 159-162
• [Journal Article] 高齢者糖尿病のメトホルミンとSGLT阻害薬の使い方 (2017)
  • Author(s): 佐藤博亮，綿田裕孝
  • Journal Title: Geriat. Med Volume: 55 Pages: 895-900
• [Journal Article] 糖尿病治療薬の効果と選択 ～糖尿病患者の病態に応じた薬物選択～ (2017)
  • Author(s): 佐藤博亮
  • Journal Title: ClLINIC magazine Volume: 584 Pages: 9-14
• [Journal Article] 病態を考慮した糖尿病治療薬の選択 基本的にはDPP-4阻害薬が第一選択薬 (2017)
  • Author(s): 佐藤博亮
  • Journal Title: ClLINIC magazine Volume: 581 Pages: 59-59
• [Journal Article] 災害と糖尿病 ~災害に強い糖尿病医療システムの構築に向けて～ (2017)
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• [Journal Article] Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats (2016)
  • Author(s): Moriya C, Satoh H
  • Journal Title: Journal of Diabetes Research Volume: 2016 Pages: 1-9
  • DOI: 10.1155/2016/3201534
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effect of evacuation on body weight after the Great East Japan Earthquake (2016)
  • Author(s): Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Kamiya K, Abe M.
  • Journal Title: Am J Prev Med Volume: 50 Issue: 5 Pages: 553-560
  • DOI: 10.1016/j.amepre.2015.10.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypoglycemia Associated with a Gastrointestinal Stromal Tumor Producing High-molecular-weight Insulin Growth Factor II: A Case Report and Literature Review (2016)
  • Author(s): Hirai H, Ogata E, Ohki S, Fukuda I, Tanaka M, Watanabe T, Satoh H
  • Journal Title: Internal Medicine Volume: 55 Issue: 10 Pages: 1309-1314
  • DOI: 10.2169/internalmedicine.55.5848
  • NAID: 130005151172
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effects of liraglutide on both hypereosinophilic insulin allergy and the characteristics of anti-insulin antibodies in type 2 diabetes mellitus: a case report. (2016)
  • Author(s): Hirai H, Ogata E, Kikuchi N, Kohno T, Machii N, Hasegawa K, Watanabe T, Satoh H.
  • Journal Title: Journal of Medical Case Report Volume: 10 Issue: 1 Pages: 1-8
  • DOI: 10.1186/s13256-016-0994-4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hypo-high-density Lipoprotein Cholesterolemia Caused by Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident: Results from the Fukushima Health Management Survey (2016)
  • Author(s): Satoh H, Ohira T, Nagai M, Hosoya M, Sakai A, Watanabe T, Ohtsuru A, Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M.
  • Journal Title: Internal Medicine Volume: 55 Issue: 15 Pages: 1967-1976
  • DOI: 10.2169/internalmedicine.55.6030
  • NAID: 130005254813
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Superior Mesenteric Artery Syndrome Complicated by Diabetic Ketoacidosis and Graves' Disease in Slowly Progressive Insulin Dependent Diabetes Mellitus (SPIDDM): A Case Report and a Review of the Literature (2016)
  • Author(s): Hirai H, Fukushima N, Hasegawa K, Watanabe T, Hasegawa O, Satoh H
  • Journal Title: Internal Medicine Volume: 55 Issue: 15 Pages: 2035-2042
  • DOI: 10.2169/internalmedicine.55.6203
  • NAID: 130005254819
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evacuation and Risk of Hypertension After the Great East Japan Earthquake: The Fukushima Health Management Survey. (2016)
  • Author(s): Ohira T, Hosoya M, Yasumura S, Satoh H, Suzuki H, Sakai A, Ohtsuru A, Kawasaki Y, Takahashi A, Ozasa K, Kobashi G, Hashimoto S, Kamiya K, Yamashita S, Abe M
  • Journal Title: Hypertension Volume: 68 Issue: 3 Pages: 558-561
  • DOI: 10.1161/hypertensionaha.116.07499
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence of Renal Dysfunction among Evacuees and Non-evacuees after the Great East Earthquake: Results from the Fukushima Health Management Survey (2016)
  • Author(s): Satoh H, Ohira T, Nagai M, Hosoya M, Sakai A, Watanabe T, Ohtsuru A, Kawasaki Y, Suzuki H, Takahashi A, Kobashi G, Ozasa K, Yasumura S, Yamashita S, Kamiya K, Abe M.
  • Journal Title: Internal Medicine Volume: 55 Issue: 18 Pages: 2563-2569
  • DOI: 10.2169/internalmedicine.55.7023
  • NAID: 130005414819
  • ISSN: 0918-2918, 1349-7235
  • Open Access / Int'l Joint Research
• [Journal Article] Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP). (2016)
  • Author(s): Fujitani Y, Fujimoto S, Takahashi K, Satoh H, Hirose T, Hiyoshi T, Ai M, Okada Y, Gosho M, Mita T, Watada H.
  • Journal Title: Diabetes Research and Clinical Practice Volume: 121 Pages: 146-156
  • DOI: 10.1016/j.diabres.2016.09.014
  • Peer Reviewed / Int'l Joint Research
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  • Author(s): Hirai H, Midorikawa S, Suzuki S, Sasano H, Watanabe T, Satoh H.
  • Journal Title: Internal Medicine Volume: 55 Issue: 20 Pages: 2985-2991
  • DOI: 10.2169/internalmedicine.55.7071
  • NAID: 130005430006
  • ISSN: 0918-2918, 1349-7235
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• [Presentation] Febuxostat Improves Insulin Resistance in the Skeletal Muscle In Vitro and In Vivo (2018)
  • Author(s): Moriya, C., Satoh, HWatada, H
  • Organizer: 78th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Hepatic G0S2 Exacerbates Hepatic Insulin Resistance in Estrogen-Deficient Female Wistar Rats (2018)
  • Author(s): Satoh, H., Sugaya, Y., Moriya, C., Miyatsuka, T.,Watada, H
  • Organizer: 78th American Diabetes Association Scientific Sessions
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• [Presentation] Effects of SGLT2 Inhibitors on lnsulin Secretion and Insulin Resistance-Results from a Cross-Sectional Study (2018)
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  • Organizer: 78th American Diabetes Association Scientific Sessions
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• [Presentation] SGLT2 inhibitors might blunt the glucagon induced insulin secretion: Results from a retrospective cross-sectional study (2018)
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• [Presentation] Liver specific G0/G1 Switch Gene (G0S2) Exacerbates Hepatic Insulin Resistance in Estrogen-Deficient Female Wistar Rats (2018)
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  • Organizer: 第50回日本動脈硬化学会総会・学術集会
• [Presentation] SGLT2阻害薬のインスリン分泌能，抵抗性に及ぼす影響についての検討 (2018)
  • Author(s): 早稲田直子, 佐藤博亮, 岩本達也, 吉田千紗, 飯田真由, 谷本眞澄, 池田富貴, 金澤昭雄,綿田裕孝
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] フェブキソスタットがインスリン抵抗性に及ぼす影響についての検討」 (2018)
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  • Organizer: 第61回日本糖尿病学会年次学術集会
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  • Author(s): 山崎聡, 佐藤博亮, 渡辺毅,島袋充生
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 遺伝性溶血性貧血を基礎疾患に持ち、糖尿病、性腺機能低下症を呈した鉄過剰症の一例 (2018)
  • Author(s): 松橋瑛子, 佐藤博亮, 谷本真澄, 飯田真由, 早稲田直子, 佐藤元律, 池田富貴, 金澤昭雄, 安藤純,小松則夫「
  • Organizer: 第55回日本糖尿病学会関東甲信越地方会
• [Presentation] 遺伝性溶血性貧血を基礎疾患に持ち、糖尿病、性腺機能低下症を呈した鉄過剰症の一例 (2018)
  • Author(s): 松橋瑛子，佐藤博亮，谷本眞澄，飯田真由，早稲田直子，佐藤元律， 池田富貴，金澤昭雄，安藤 純，小松則夫，綿田裕孝
  • Organizer: 日本糖尿病学会第55回関東甲信越地方会.
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  • Author(s): Satoh H, Ohira T, Moriya C, Inoue I, Kurabayashi S, Seino H, Hirai H, Hiyoshi T, Watada H.
  • Organizer: 77th American Diabetes Association Scientific Sessions.
  • Int'l Joint Research
• [Presentation] Febuxostat improves skeletal muscle insulin resistance via upregulating skeletal muscle PGC-1a expression in high-fat diet-fed male Wistar rats. (1985-P) (2017)
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  • Organizer: 77th American Diabetes Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Febuxostat improves skeletal muscle insulin resisitance via upregulating skeletal muscle PGC-1αexpression in high fat diet male Wistar rats. (480) (2017)
  • Author(s): Moriya C, Satoh H, Watada H
  • Organizer: 53rd Annual meeting of the European Association for the Study of Diabetes
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• [Presentation] 2型糖尿病患者におけるリナグリプチンの血糖日内変動に及ぼす影響の検討（L-CGM study）(Ⅰ-9-13) (2017)
  • Author(s): 佐藤博亮，大平哲也，森谷千尋，井上郁夫，栗林伸一，清野弘明，平井裕之，日吉徹，綿田裕孝
  • Organizer: 第60回日本糖尿病学会年次学術集会
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  • Author(s): 岩崎麻里子，工藤明宏，尾形絵美，待井典剛，佐藤博亮，井関邦敏，守山敏樹，山縣邦弘，鶴屋和彦，藤元昭一，成田一衛，今田恒夫，近藤正英，柴垣有吾，笠原正登，旭浩一，渡辺毅，島袋充生
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 空腹時血糖レベル・HbA1cレベル別にみた新規糖尿病発症リスク (Ⅰ-P-527) (2017)
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  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病薬剤別にみた血糖管理目標達成割合の検討：福島県立医科大学生活習慣病コホートを用いた横断研究 (Ⅱ-P-138) (2017)
  • Author(s): 平井裕之，五十嵐彩華，武田光樹，田辺隼人，金成文平，鴻野央征，岩崎麻里子，森谷千尋，尾形絵美，菅谷芳幸，待井典剛，工藤明宏，佐藤博亮，田中健一，旭浩一，渡辺毅，風間順一郎，島袋充生
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 食行動要因の糖尿病新規発症におよぼす影響：特定健診受診者における解析 (Ⅱ-P-595) (2017)
  • Author(s): 工藤明宏，尾形絵美，待井典剛，佐藤博亮，井関邦敏，守山敏樹，山縣邦弘，鶴屋和彦，藤元昭一，成田一衛，今田恒夫，近藤正英，柴垣有吾，笠原正登，旭浩一，渡辺毅，島袋充生
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 糖尿病薬物療法の効果判定における内因性インスリン分泌測定の意義 (Ⅲ-P-472) (2017)
  • Author(s): 鴻野央征，五十嵐彩華，武田光樹，田辺隼人，金成文平，森谷千尋，尾形絵美，菅谷芳幸，待井典剛，平井裕之，工藤明宏，佐藤博亮，島袋充生
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 東日本大震災前後の体重，HbA1cの変動：福島県立医科大学通院中の2型糖尿病患者における検討 (Ⅲ-P-477) (2017)
  • Author(s): 待井典剛，五十嵐彩華，武田光樹，田辺隼人，金成文平，鴻野央征，岩崎麻里子，尾形絵美，菅谷芳幸，平井裕之，工藤明宏，佐藤博亮，田中健一，旭浩一，渡辺毅，風間順一郎，島袋充生
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 横紋筋融解症および敗血症を伴った劇症１型糖尿病の1例 (2016)
  • Author(s): 武田光樹、待井典剛、五十嵐彩華、田辺隼人、鴻野央征、金成文平、菅谷芳幸、平井裕之、工藤明宏、佐藤博亮
  • Organizer: 日本糖尿病学会第54回東北地方会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-11-12
• [Presentation] 静脈性血管腫を合併した低血糖性意識障害の一例 (2016)
  • Author(s): 田辺隼人、待井典剛、五十嵐彩華、武田光樹、冨田重博、金成文平、鴻野央征、菅谷芳幸、平井裕之、工藤明宏、佐藤博亮
  • Organizer: 日本糖尿病学会第54回東北地方会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-11-12
• [Presentation] 低血糖で救急外来を受診したケトアシドーシスの一例 (2016)
  • Author(s): 209.五十嵐彩華、菅谷芳幸、武田光樹、田辺隼人、冨田重博、金成文平、鴻野央征、待井典剛、平井裕之、工藤明宏、佐藤博亮
  • Organizer: 日本糖尿病学会第54回東北地方会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-11-12
• [Presentation] Teneligliptin decreases the uric acids levels by reducing xanthine dehydrogenase expression in White adipose tissue of the male Wister rats. (568) (2016)
  • Author(s): Moriya Tsukagoshi C, Satoh H
  • Organizer: 52nd Annual meeting of the European Association for the Study of Diabetes.
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] アデホビルにより薬剤性fanconi症候群をきたした低リン血症性骨軟化症の一例 (2016)
  • Author(s): 五十嵐 彩華、菅谷 芳幸、武田 光樹、田辺 隼人、冨田 重博、金成 文平、鴻野 央征、待井 典剛、佐藤博亮
  • Organizer: 第209回日本内科学会東北地方会
  • Place of Presentation: 山形県山形市
  • Year and Date: 2016-09-10
• [Presentation] 慢性腎臓病患者の血清リン値と心血管リスク・腎予後の関連について―福島CKDコホート研究― (2016)
  • Author(s): 田中健一，菅野真理，木村浩，林義満，佐藤博亮，中山昌明，渡辺毅，旭浩一
  • Organizer: 第59回 日本腎臓学会年次学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-06-17
• [Presentation] 糖尿病性腎症における腎機能低下の要因についての検討 (2016)
  • Author(s): 菅野真理，田中健一，林義満，佐藤博亮，中山昌明，渡辺毅，旭浩一
  • Organizer: 第59回 日本腎臓学会年次学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-06-17
• [Presentation] Teneligliptin decreases the uric acids levels by reducing xanthine oxidoreductase expression in white adipose tissue of the male Wistar rats. (1919-P) (2016)
  • Author(s): Moriya Tsukagoshi C, Satoh H
  • Organizer: 76th American Diabetes Association Scientific Sessions.
  • Place of Presentation: New Orleans, LA，ＵＳＡ
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] Effects of Linagliptin Monotherapy Compared with Voglibose on Postprandial Blood Glucose Responses in Japanese Patients with Type 2 Diabetes: Linagliptin Study of Effects on Postprandial Blood Glucose (L-STEP) (1172-P) (2016)
  • Author(s): Fujitani Y, Fujimoto S, Takahashi K, Satoh H, Hirose T, Ai M, Okada Y, Gosho M, Mita T, Watada H
  • Organizer: 6th American Diabetes Association Scientific Sessions.
  • Place of Presentation: New Orleans, LA，ＵＳＡ
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] テネリグリプチンは白色脂肪組織でのxanthne dehydrogenase (XDH)発現を抑制して尿酸値を低下させる (2016)
  • Author(s): 森谷千尋，佐藤博亮
  • Organizer: 59回 日本糖尿病学会年次学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2016-05-19
• [Presentation] 当科におけるインスリングラルギン デテミルからデグルデグへの切り替えによる検討 (2016)
  • Author(s): 冨田重博，田辺隼人，金成文平，鴻野央征，森谷千尋，尾形絵美，待井典剛，菅谷芳幸，平井裕之，工藤明宏，佐藤博亮
  • Organizer: 第59回 日本糖尿病学会年次学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2016-05-19
• [Presentation] リナグリプチンの食後血糖に及ぼす効果の検討：Linagliptin Study of Effect on Postprndial blood glucose (L-STEP)研究 (2016)
  • Author(s): 藤谷与士夫，藤本新平，高橋清仁，佐藤博亮，弘世貴久，日吉徹，藍真澄，岡田洋右，五所正彦，三田智也，綿田裕孝
  • Organizer: 第59回 日本糖尿病学会年次学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2016-05-19