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Development of new treatment for liver cancer by the functional analysis of the hepatoma-derived growth factor and its receptor, nucleolin

Research Project

Project/Area Number 16K09383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionHyogo Medical University

Principal Investigator

Enomoto Hirayuki  兵庫医科大学, 医学部, 准教授 (40449880)

Co-Investigator(Kenkyū-buntansha) 西口 修平  兵庫医科大学, 医学部, 教授 (10192246)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝癌由来増殖因子 / 肝細胞癌 / microRNA / Nucleolin / HDGF / アレイシステム / 細胞増殖 / Sorafenib / Xenograft model / 肝癌由来増殖因子(HDGF) / ヌクレオリン
Outline of Final Research Achievements

We discovered a new factor involved in the growth of liver cancer, hepatoma-derived growth factor (HDGF). In this study, we found that the nucleokin (NCL), a functional receptor of HDGF, was expressed in hepatoma cells. In addition, reduction of HDGF suppressed the growth of hepatoma cells through the mechanism which was different from the sorafenib treatment. In addition, we examined the changes in the microRNA expressions in response to the HDGF administration, and identified the microRNAs that commonly increased or decreased in two different hepatoma cell lines. These results provide new findings regarding the growth of liver cancer and are expected to contribute to develop a new treatment strategy for the liver cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究ではHDGFが新たな肝癌治療の標的となりうること、またHDGFの投与で変動するmicroRNAを新たに同定した。これらの知見は、肝癌増殖機序解明と治療法開発への貢献が期待できる。またHDGFは肝癌以外にも様々な臓器における癌増殖への関与が報告されている。したがって本研究の結果は、多種類の癌の増殖機序解明へつながることも期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017 2016

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Identification of microRNAs potentially associated with HDGF(hepatoma-derived growth factor)-stimulating cellular proliferation in hepatoma cells2019

    • Author(s)
      Enomoto H, Nishiguchi S, et al.
    • Organizer
      JSH International Liver Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hepatoma-derived growth factor as a potential therapeutic target for2018

    • Author(s)
      Enomoto H, Nishiguchi S, et al.
    • Organizer
      The 25th APASL Single Topic Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肝癌由来増殖因子(HDGF)によるmicroRNA変動の検討2017

    • Author(s)
      榎本平之、中村秀次、 西口修平 他
    • Organizer
      第42回日本肝臓学会西部会
    • Related Report
      2017 Research-status Report
  • [Presentation] Sorafenibの抗腫瘍効果増強の試み:インターフェロン併用の可能性について2016

    • Author(s)
      榎本平之、辻村亨、 西口修平
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張(千葉県千葉市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Anti-HDGF (hepatoma-derived growth factor) treatment as a possible new therapy for hepatocellular carcinoma2016

    • Author(s)
      Enomoto H, Nakamura H, Nishikawa H, et al.
    • Organizer
      23rd International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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