Explorateive research of biomarkers for coronary microvascular dysfunction in the patients with vasospastic angina

• Project/Area Number: 16K09413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Takahashi Jun 東北大学, 大学病院, 講師 (00375081)
• Co-Investigator(Kenkyū-buntansha): 下川 宏明 東北大学, 医学系研究科, 教授 (00235681)
• Research Collaborator: Odaka Yuji ; Nihei Taro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 冠攣縮性狭心症 / 微小血管型狭心症 / バイオマーカー / 冠微小循環障害 / Rhoキナーゼ / 血漿セロトニン / 微小血管抵抗指数 / 冠攣縮 / 狭心症 / 循環器・高血圧

Outline of Final Research Achievements

We had two major findings in the present study. At first, we demonstareted that Rho-kinase activity in circulating leucocytes is a useful biomarker for not only diagnosis and disease activity assessment but also prognostic stratification of the patients with vasospastic angina (VSA). Second, we showed that plasma concentration of serotonin may be a novel biomarker for coronary microvascular dysfunction in patients with angina and unobstructive coronary arteries.

Academic Significance and Societal Importance of the Research Achievements

前述したバイオマーカーの発見は両者とも世界で初めてのことであり、それらバイオマーカーを利用することによって、冠攣縮性狭心症患者の中でも長期予後が不良であったり、微小血管障害を合併するなどのハイリスク患者を層別化することが可能となり、それら難治性冠攣縮における新たな治療戦略の確立につながることが期待される。

Research Products

• [Journal Article] Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina. (2018)
  • Author(s): Nihei T, Takahashi J, Hao K, Kikuchi Y, Odaka Y, Tsuburaya R, Nishimiya K, Matsumoto Y, Ito K, Miyata S, Sakata Y, Shimokawa H.
  • Journal Title: European Heart Journal Volume: 39 Issue: 11 Pages: 952-959
  • DOI: 10.1093/eurheartj/ehx657
  • Peer Reviewed
• [Journal Article] Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries. (2017)
  • Author(s): Odaka Y, Takahashi J, Tsuburaya R, Nishimiya K, Hao K, Matsumoto Y, Ito K, Sakata Y, Miyata S, Manita D, Hirowatari Y, Shimokawa H.
  • Journal Title: European Heart Journal. Volume: 38 Pages: 489-496
  • DOI: 10.1093/eurheartj/ehw448
  • Peer Reviewed
• [Presentation] Prognostic impacts of impaired coronary vasodilatation and enhanced coronary vasoconstricting responses in patients with angina and unobstructive coronary arteries. (2018)
  • Author(s): 28.Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Plasma Levels of Serotonin as a Novel Biomarker for Co presence of Coronary Microvascular (2017)
  • Author(s): Yuji Odaka
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市、石川県立音楽堂
  • Year and Date: 2017-03-17
  • Int'l Joint Research
• [Presentation] Sex Difference in Diagnostic Value of Surrogate Markers for Reflecting Coronary Microvascular Dysfunction (2017)
  • Author(s): Jun Takahashi, Akira Suda, Yuji Odaka, Kiyotaka Hao, Yoku Kikuchi, Shohei Ikeda, Tomohiko Shindo, Yasuharu Matsumoto,
  • Organizer: The 8th Congress of International Society of Gender Medicine
  • Int'l Joint Research / Invited