IgG4-related disease of myocardium, pericardium and coronary arteries and its possible physiological consequence.
| Project/Area Number |
16K09483
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
勝間田 敬弘 大阪医科大学, 医学部, 教授 (60224474)
寺崎 文生 大阪医科大学, 医学部, 教授 (20236988)
神崎 裕美子 大阪医科大学, 医学部, 講師 (80445999)
藤田 修一 大阪医科大学, 医学部, 講師 (80722628)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IgG4関連疾患 / 大動脈弁狭窄症 / 大動脈弁 / 血清IgG4値 / 大動脈周囲炎 / 動脈周囲炎 / 大動脈弁膜症 / 臓器特異的診断基準 / 炎症性大動脈瘤 / 炎症性動脈周囲炎 / 炎症性心膜炎 / 大動脈瘤 / 循環器・高血圧 |
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| Outline of Final Research Achievements |
Infiltration of IgG4-positive plasma cells in the cardiovascular tissue, especially aorta and aortic valve, has been investigated. IgG4-positive cell infiltration >10/HPF was observed in 14% of aortic samples and 2.3% of aortic valve samples. The patients who had IgG4-positive cell infiltration in these tissues had higher pre-operative serum IgG4 value compared with those without such infiltration, although no patient demonstrated pre-operative serum IgG4 >135 mg/dL. On the other hand, we could not find significant association between IgG4-positive cell infiltration of aortic valve samples and pre-operative aortic valve pressure gradient. IgG4-positive cell infiltration in the cardiac structure and aorta is not a rare finding; however, its pathophysiological importance awaits further investigations.
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| Academic Significance and Societal Importance of the Research Achievements |
心臓や大血管でも、IgG4関連疾患を疑わせるケースにしばしば遭遇するが、組織サンプリングが現実的ではないため確診にいたらないケースも多い。今回、心血管手術により取得された組織サンプルの組織学的検討を行い、染色の結果と、血清IgG4値や臨床像、疾患重症度との関連を検討するという逆行的な方法論を用い、大動脈弁膜症においてIgG4陽性細胞の浸潤が稀な現象ではないこと、陽性細胞浸潤が、重症度とはかならずしも関連しないことを示した。このことにより、インシデンタルにIgG4陽性細胞浸潤が発見された場合でも、どの程度のrarityや意義づけが可能なのかに対する、一つの視点が提供できたものと考える。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples.2017
Author(s)
Hourai R, Kasashima S, Sohmiya K, Yamauchi Y, Ozawa H, Hirose Y, Ogino Y, Katsumata T, Daimon M, Fujita SI, Hoshiga M, Ishizaka N.
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Journal Title
BMC Cardiovasc Disord
Volume: 17（1）
Issue: 1
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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