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Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation

Research Project

Project/Area Number 16K09498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

NAKAGAWA YASUAKI  京都大学, 医学研究科, 助教 (70452357)

Co-Investigator(Kenkyū-buntansha) 桑原 宏一郎  信州大学, 学術研究院医学系, 教授 (30402887)
錦見 俊雄  京都大学, 医学研究科, 非常勤講師 (80291946)
Research Collaborator MINAMINO NAOTO  国立研究開発法人 国立循環器病研究センター
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糖鎖修飾 / proBNP / 糖鎖 / 分子心臓病学 / 循環器・高血圧
Outline of Final Research Achievements

BNP is secreted from the heart and is a cardioprotective peptide, but its precursor proBNP is present in the blood and its biological activity is extremely weak compared to BNP. However, the secretion mechanism of this proBNP was unknown. In this study, we suggested that miR-30, a microRNA abundant in the heart, regulates the gene expression of the O-linked glycosyltransferases, GALNT1 and GALNT2, in a repressive manner, thereby regulating the glycosylation of proBNP by GALNT1 and GANT2, and that miR-30-GALNT pathway is involved in the glycosylation-dependent regulation of the processing and secretion of proBNP.

Academic Significance and Societal Importance of the Research Achievements

本研究により、低活性のproBNP分泌メカニズムの一端が明らかとなり、これらの分子メカニズムを修飾することで、心不全の新たな診断法や、活性の強いBNPの分泌が促進されるような新たな心不全治療の開発につながる可能性が有る意義のある研究成果が得られたと考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (58 results)

All 2019 2018 2017 2016 Other

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (45 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Atrial and brain natriuretic peptides: Hormones secreted from the heart2019

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K.
    • Journal Title

      Peptides

      Volume: 111 Pages: 18-25

    • DOI

      10.1016/j.peptides.2018.05.012

    • NAID

      120006817603

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cutting Edge of Brain Natriuretic Peptide (BNP) Research ― The Diversity of BNP Immunoreactivity and Its Clinical Relevance ―2018

    • Author(s)
      Kuwahara K, Nakagawa Y, Nishikimi T.
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 10 Pages: 2455-2461

    • DOI

      10.1253/circj.CJ-18-0824

    • NAID

      130007489414

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-09-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method.2018

    • Author(s)
      Kuwabara J, Kuwahara K, Kuwabara Y, Yasuno S, Nakagawa Y, Ueshima K, Kimura T
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 11 Pages: e0206945-e0206945

    • DOI

      10.1371/journal.pone.0206945

    • NAID

      120006539573

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure2018

    • Author(s)
      Takahama Hiroyuki、Takashio Seiji、Nishikimi Toshio、Hayashi Tomohiro、Nagai-Okatani Chiaki、Nakagawa Yasuaki、Amaki Makoto、Ohara Takahiro、Hasegawa Takuya、Sugano Yasuo、Kanzaki Hideaki、Yasuda Satoshi、Kangawa Kenji、Minamino Naoto、Anzai Toshihisa
    • Journal Title

      International Journal of Cardiology

      Volume: 258 Pages: 165-171

    • DOI

      10.1016/j.ijcard.2017.12.047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin as a Biomarker2018

    • Author(s)
      Nishikimi T, Nakagawa Y
    • Journal Title

      Heart Fail Clin

      Volume: 14 Issue: 1 Pages: 49-55

    • DOI

      10.1016/j.hfc.2017.08.006

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP:Case report.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T.
    • Journal Title

      Clinical Biochemistry

      Volume: 52 Pages: 148-152

    • DOI

      10.1016/j.clinbiochem.2017.10.019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.2017

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Journal Title

      J Am Heart Assoc.

      Volume: 6 Issue: 2

    • DOI

      10.1161/jaha.116.003601

    • NAID

      120007100125

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity.2017

    • Author(s)
      Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
    • Journal Title

      Hypertension.

      Volume: 69 Issue: 2 Pages: 286-296

    • DOI

      10.1161/hypertensionaha.116.08219

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy2016

    • Author(s)
      Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
    • Journal Title

      Cardiovascular Research

      Volume: 109 Issue: 1 Pages: 162-173

    • DOI

      10.1093/cvr/cvv248

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Pro-B type natriuretic peptide (BNP) to total BNP ratio is involved in the pathphysiology of acute and chronic heart failure: elucidateon of molecura mechanism.2018

    • Author(s)
      Toshio Nikishikimi, Yasuaki Nakagawa, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriutchi, Hiromu Yanagisawa, Koichiro Kuwahara, Hiroyuki Takahama, Naoto Minamino, Takeshi Kimura
    • Organizer
      ISH(Internal Society of Hypertension) 2018 Scientific Meeting.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possibility of proBNP measurement as a new methods for evaluating the heart disease2018

    • Author(s)
      Yasuaki Nakagawa
    • Organizer
      第82回 日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] G蛋白サブユニットGαoのCa2+ handling恒常性および心収縮能維持における意義の解明.2018

    • Author(s)
      稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、錦見俊雄、呉林なごみ、山田充彦、柏原俊英、中尾一和、木村剛
    • Organizer
      第55回日本臨床分子医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心不全モデルマウスにおけるG蛋白サブユニットGαoの発現亢進はCa2+ handlingの異常をきたし心収縮能低下に関与する.2018

    • Author(s)
      稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、錦見俊雄、呉林なごみ、山田充彦、中尾一和、木村剛.
    • Organizer
      第91回 日本内分泌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 左心疾患を合併した強皮症関連肺動脈性肺高血圧症の臨床的特徴2018

    • Author(s)
      柳澤 洋, 木下 秀之, 吉藤 元, 森内 健史, 稲住 英明, 斎藤 成達, 中川 靖章, 尾野 亘, 桑原 宏一郎, 木村 剛
    • Organizer
      第3回 日本肺高血圧・肺循環学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Increased Gαo expression underlies cardiac dysfunction accompanied with abnormal Ca2+ handling.2018

    • Author(s)
      Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Oya M, Nishikimi T, Kurebayashi N, Yamada M, Nakao K Kimura T.
    • Organizer
      第2回日本循環器学会基礎研究フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺移植実施施設からみた病診・病病連携の重要性2018

    • Author(s)
      木下秀之、柳澤洋、森内健治、稲住英明、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺動脈性肺高血圧症に対する肺移植術における循環器内科の役割2018

    • Author(s)
      木下秀之、柳澤洋、森内健治、稲住英明、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺高血圧症に伴う得心不全の診断と治療2018

    • Author(s)
      木下秀之、柳澤洋、森内健治、稲住英明、加藤貴雄、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A case of left heart failure and pulmonary hypertension during treatment of nintedanib for idiopathic pulmonary fibrosiss2018

    • Author(s)
      Munekazu Tanaka, Hideyuki Kinoshita, Takunori Aizawa, Hiromu Yangisawa, Kenji Moriuchi, Hideyuki Inazumi, Takao kato, Naritatsu Saito, Yasuaki Nakagawa, Koh Ono, Koichiro Kuwahara, Takeshi Kimura
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clinical features of the Systemic Sclerosis Associated Pulmonar Arterial Hypertension in the Elderly2018

    • Author(s)
      Masaharu Yoshida, Hideyuki Kinoshita, Munekazu Tanaka, Kazuki Kitano, Hiromu Yangisawa, Kenji Moriuchi, Hideyuki Inazumi, Takao kato, Naritatsu Saito, Yasuaki Nakagawa, Koh Ono, Koichiro Kuwahara, Takeshi Kimura
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナトリウム利尿ペプチドを知る~BNPの最近の話題を中心に~2018

    • Author(s)
      中川靖章
    • Organizer
      第28回臨床内分泌代謝Update
    • Related Report
      2018 Annual Research Report
  • [Presentation] Adipocyte-derived adrenomedullin suppresses age-and obesity-related increase in blood pressure2017

    • Author(s)
      Kosai Cho, Takeya Minami, Koichiro Kuwahara, Toshio Nishikimi, Hideaki Kinoshita, Kenji Moriuti, Kaoru Koike, Kenji Naoto Minamino, KangawaYasuaki Nakagawa, Hideyuki Kinoshita, Kazuwa Nakao, Takeshi Kimura
    • Organizer
      The81st Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 僧帽弁逆流の成因解明にストレインエコーが有用であった心サルコイドーシスの一症例2017

    • Author(s)
      米田智也、木下秀之、中島康弘、相澤卓範、岡林真梨恵、中川靖章、桑原宏一郎、木村剛
    • Organizer
      The81st Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Prediction of poor otcome after PAH targeted therapy in pulmonary arterial hypertension patients with lung disease2017

    • Author(s)
      Hideyuki Kinoshita, Takanari Fujita, HiromuYanagisawa, Kenji Moriuchi, Hideaki Inazumi, Narituatsu Saitoh, Yasuaki Nakagawa, Koichiro Kuwahara, Koh Ono, Takeshi Kimura
    • Organizer
      The81st Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] O-linked oligosaccharide atachment underestimates N-terminal proBNP(NT-proBNP) levels in heart failure (HF) and chronic renal failure (CRF) on hemodyalysis (HD)2017

    • Author(s)
      Toshio Nishikimi, Yasuaki Nakagawa, Koichiro Kuwahara, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Kazuwa Nakao, Takeshi Kimura
    • Organizer
      The81st Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] BNPを識る、そして病態を読む2017

    • Author(s)
      中川靖章
    • Organizer
      The81st Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 基礎から考えるBNP検査の臨床応用2017

    • Author(s)
      中川靖章
    • Organizer
      STROKE2017
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] O-linked oligosaccharaide attachment underestimates N-treminal proBNP-76(NT-proBNP) levels in heart failure(HF) and chronic renal failure (CRF) on hemodialysis (HD)2017

    • Author(s)
      Nishikimi T, Nakagawa Y, Kinoshita H, Moriuchi K, Inazumi H, Kuwahara K, Nakao K, Kimura T.
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adipocyte-derived adrenomedullin suppresses age-and obesity-related increase in blood pressure2017

    • Author(s)
      Cho Kozai, Takeya Minami, Toshio Nishikimi, Yasuaki Nakagawa, Kazuwa Nakao, Koichiro Kuwahara, Kaoru Koike, Takeshi Kimura
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of continuous reduction in B-type natriuretic peptide bioactivity during hospitalization in patients with advanced heart failure2017

    • Author(s)
      Takahama H, Takashio S, Hayashi T, Okatani-Nagai C, Nishikimi T, Nakagawa Y, Amaki M, Ohara T, Hasegawa T, Sugano Y, Kanzaki H, Yaduda S, Kangawa K, Minamino N, Anzai T
    • Organizer
      AHA Scientific Session 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molar ratio of N-terminal fragment of pro-B-type natriuretic peptide(BNP) to proBNP predicts occurrence of acute kiney injury in patients with acute heart failure2017

    • Author(s)
      Takahama H, Takashio S, Hayashi T, Nishikimi T, Nakagawa Y, Amaki M, Hasegawa T, Sugano Y, Kanzaki H, Yaduda S, Kangawa K, Minamino N, Anzai T.
    • Organizer
      AHA Scientific Session 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脂肪由来のアドレノメデュリンは加齢および肥満に伴う血圧上昇を抑制する2017

    • Author(s)
      趙晃済、桑原宏一郎、南丈也、錦見俊雄、南野直人、中川靖章、木下秀之、稲住英明、森内健史、寒川賢治、中尾一和、木村剛
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 心臓サルコイドーシスにおける診断と免疫抑制療法2017

    • Author(s)
      柳澤洋、加藤 貴雄, 木下 秀之, 中川 靖章, 猪子 森明, 木村 剛
    • Organizer
      第3回 日本心筋症研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] サルコイドーシスにおける診断モダリティとステロイド治療.2017

    • Author(s)
      柳澤洋、加藤 貴雄, 木下 秀之, 中川 靖章, 猪子 森明, 木村 剛
    • Organizer
      第65回日本心臓病学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院における左心疾患を合併した強皮症関連肺動脈性廃屋血圧症の臨床的特徴2017

    • Author(s)
      柳澤洋、木下秀之、北野一樹、田中宗和、今田一彰、吉田雅晴、辰島正二郎、森内健史、稲住英明、齋藤成達、中川靖章、尾野亘、木村剛
    • Organizer
      第21回日本心不全学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 呼吸器疾患を合併した肺動脈性肺高血圧症患者に対するイロプロスト吸入薬の急性効果の検討2017

    • Author(s)
      田中宗和、木下秀之、柳澤洋、今田一彰、吉田雅晴、森内健史、齋藤成達、中川靖章、尾野亘、木村剛
    • Organizer
      第21回日本心不全学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] A case of Macro-pro-B-Type Natriuretic Peptide (proBNP)2017

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Hiroshi Sakai, Seiko Ohno, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Koichiro Kuwahara, Minoru Horie, Takeshi kimura
    • Organizer
      第21回日本心不全学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロproBNP血症の一例2017

    • Author(s)
      中川靖章、錦見俊雄、酒井宏、大野聖子、木下秀之、稲住英明、森内健史、柳澤洋、桑原宏一郎、堀江稔、木村剛
    • Organizer
      第21回心血管内分泌代謝学会(CVMW2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] アドレノメデュリンは加齢や肥満に伴う高血圧を抑制する2017

    • Author(s)
      趙晃済、桑原宏一郎、錦見俊雄、中川靖章、木下秀之、南丈也、稲住英明、森内健史、大矢未来、南野直人、木村剛、寒川賢治、中尾一和
    • Organizer
      脳心血管抗加齢研究会2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Possibility of proBNP measurement as a new method for evaluating the heart disease2017

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Hideyuki, Kinoshita, Hideaki Inazumi, Kenji Moriuchi, HIromu Yanagisawa, Naoto Minamino, kazuwa Nakao, Koichiro Kuwahara, Takeshi Kimura
    • Organizer
      第82日本循環器学科学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 病的心筋におけるmiR30-GALNT経路による糖鎖修飾を介したproBNP分泌制御2016

    • Author(s)
      中川靖章、錦見俊雄、桑原宏一郎、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
    • Organizer
      第20回日本心血管内分泌代謝学会総会(CVMW2016)
    • Place of Presentation
      東京
    • Year and Date
      2016-12-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Secretion of proBNP is regulated by MiR30-GALNTs axis dependent O-linked glycosylation in the pathological myocardium.2016

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Takao Kato, Naoto Minamino, Kazuwa Nakao, Takeshi Kimura
    • Organizer
      AHA Scientific Session 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Endogenous plasma NT-BNP is glycosylated and undetectable with the current NT-BNP assay system2016

    • Author(s)
      Toshio Nishikimi, Yasuaki Nakagawa, Koichiro Kuwahara, Hideyuki Kinoshita, Chinatsu Yamada, Takeshi Kimura, Kazuwa Nakao
    • Organizer
      Hypertension Seoul 2016, The 26th Scientific meeting of the International Society of Hypertension
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] MiR30-GALNT1/2 axis-mediatede glycosylation regulates the increase in inactive human pro-BNP secretion from failing heart.2016

    • Author(s)
      Koichiro Kuwahara, Yasuaki Nakagawa, Toshio Nishikimi, Hideyuki Kinoshita, Hiroyuki Okamoto, Takao Kato, Kenji Kangawa, Naoto Minamino, Kazuwa Nakao, Takeshi Kimura
    • Organizer
      Hypertension Seoul 2016, The 26th Scientific meeting of the International Society of Hypertension
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 病的心筋からの脳性ナトリウム利尿ペプチド前駆体proBNP分泌はmiR-30-GALNT経路により制御されている2016

    • Author(s)
      中川靖章、桑原宏一郎、錦見俊雄、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
    • Organizer
      Molecular Cardiovascular Conference II 2016
    • Place of Presentation
      東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Unprocessed proBNP secretion is regulated by MiR30-GALNTs axis dependent O-glycosylation in the pathological myocardium..2016

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Hideyuki Kinoshita, Chinatsu Yamada, Hideaki Inazumi, Kazuwa Nakao, Takeshi Kimura
    • Organizer
      AHA BCVS2016
    • Place of Presentation
      Phoenix, Arizona, USA
    • Year and Date
      2016-07-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] miR30-GALNT経路によるO型糖鎖修飾調節を介した病的心からのproBNP分泌亢進機序2016

    • Author(s)
      中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、稲住英明、森内健史、上嶋健治、南野直人、中尾一和、木村剛
    • Organizer
      第2回 国際心血管薬物療法学会日本部会(J-ICPS)
    • Place of Presentation
      徳島
    • Year and Date
      2016-06-25
    • Related Report
      2016 Research-status Report
  • [Presentation] MiR30-GALNT1/2 axis-mediated glycosylation at threonine 48 and 71 plays an essential role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing hearts2016

    • Author(s)
      Kuwahara K, Nakagawa Y, Nishikimi T, Kangawa K, Minamino N, Nakao K, Kimura T.
    • Organizer
      Heart Failure 2016
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] デュアルインピーダンス法により計測された内臓脂肪面積と自宅血圧の日間変動指標との関連の検討2016

    • Author(s)
      桒原純子,桑原宏一郎,堀井和子,桒原佳宏,保野慎治,保野明子,藤永有里子,中川靖章,木下秀之,山田千夏,横井秀基,曽根正勝,上嶋健治,中尾一和,木村剛
    • Organizer
      第5回 日本高血圧学会 臨床高血圧フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
  • [Presentation] O型糖転移酵素GALNTのBNPプロセシング調節への関与2016

    • Author(s)
      中川靖章、錦見俊雄、桑原宏一郎、木下秀之、山田千夏、稲住英明、南野直人、中尾一和、木村剛
    • Organizer
      第89回 日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] miR30-GALNT経路によるO型糖鎖修飾を介したBNPプロセシング調節が病的心筋からのproBNP分泌亢進に寄与する2016

    • Author(s)
      中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、山田千夏、稲住英明、上嶋健治、南野直人、中尾一和、木村剛
    • Organizer
      第53回 日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] MiR30-GALNTs axis-mediated O-glycosylation plays an important role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing heart2016

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Kazuwa Nakao and Takeshi Kimura
    • Organizer
      Keystone symposia
    • Place of Presentation
      Snowbird, Utah, ISA
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] miR-30-GALNT1,2経路による糖鎖修飾調節が病的心筋からのproBNP分泌に関与する2016

    • Author(s)
      中川靖章、錦見俊雄、桑原宏一郎、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
    • Organizer
      第26回 日本循環薬理学会
    • Place of Presentation
      松本
    • Related Report
      2016 Research-status Report
  • [Presentation] G蛋白サブユニットGαoの発現亢進が拡張型心筋症モデルマウスにおける心機能低下に関与する2016

    • Author(s)
      稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、森内健史、錦見俊雄、呉林なごみ、柏原俊英、山田充彦、中尾一和、木村剛
    • Organizer
      第26回 日本循環薬理学会
    • Place of Presentation
      松本
    • Related Report
      2016 Research-status Report
  • [Book] Endocrinology of the Heart in Health and Disease. Chapter 2 Adrenomedullin.2017

    • Author(s)
      T. Nishikimi, K. Kuwahara, Y. Nakagawa, K Kangawa, and K. Nakao
    • Total Pages
      18
    • Publisher
      Elsevier Scinence
    • Related Report
      2016 Research-status Report
  • [Remarks] 京都大学医学部附属病院 循環器内科 心血管内分泌代謝グループ

    • URL

      http://kyoto-u-cardio.jp/kisokenkyu/cat236/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 京都大学大学院医学研究科循環器内科心血管内分泌代謝グループ

    • URL

      http://kyoto-u-cardio.jp/kisokenkyu/cat236/

    • Related Report
      2017 Research-status Report
  • [Remarks] 京都大学医学部付属病院循環器内科 心血管内分泌代謝グループ

    • URL

      http://kyoto-u-cardio.jp/kisokenkyu/cat236/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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