Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation

• Project/Area Number: 16K09498
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: NAKAGAWA YASUAKI 京都大学, 医学研究科, 助教 (70452357)
• Co-Investigator(Kenkyū-buntansha): 桑原 宏一郎 信州大学, 学術研究院医学系, 教授 (30402887) ; 錦見 俊雄 京都大学, 医学研究科, 非常勤講師 (80291946)
• Research Collaborator: MINAMINO NAOTO 国立研究開発法人 国立循環器病研究センター
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 糖鎖修飾 / proBNP / 糖鎖 / 分子心臓病学 / 循環器・高血圧

Outline of Final Research Achievements

BNP is secreted from the heart and is a cardioprotective peptide, but its precursor proBNP is present in the blood and its biological activity is extremely weak compared to BNP. However, the secretion mechanism of this proBNP was unknown. In this study, we suggested that miR-30, a microRNA abundant in the heart, regulates the gene expression of the O-linked glycosyltransferases, GALNT1 and GALNT2, in a repressive manner, thereby regulating the glycosylation of proBNP by GALNT1 and GANT2, and that miR-30-GALNT pathway is involved in the glycosylation-dependent regulation of the processing and secretion of proBNP.

Academic Significance and Societal Importance of the Research Achievements

本研究により、低活性のproBNP分泌メカニズムの一端が明らかとなり、これらの分子メカニズムを修飾することで、心不全の新たな診断法や、活性の強いBNPの分泌が促進されるような新たな心不全治療の開発につながる可能性が有る意義のある研究成果が得られたと考える。

Research Products

• [Journal Article] Atrial and brain natriuretic peptides: Hormones secreted from the heart (2019)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K.
  • Journal Title: Peptides Volume: 111 Pages: 18-25
  • DOI: 10.1016/j.peptides.2018.05.012
  • NAID: 120006817603
  • Peer Reviewed / Open Access
• [Journal Article] Cutting Edge of Brain Natriuretic Peptide (BNP) Research ― The Diversity of BNP Immunoreactivity and Its Clinical Relevance ― (2018)
  • Author(s): Kuwahara K, Nakagawa Y, Nishikimi T.
  • Journal Title: Circulation Journal Volume: 82 Issue: 10 Pages: 2455-2461
  • DOI: 10.1253/circj.CJ-18-0824
  • NAID: 130007489414
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-09-25
  • Peer Reviewed / Open Access
• [Journal Article] Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method. (2018)
  • Author(s): Kuwabara J, Kuwahara K, Kuwabara Y, Yasuno S, Nakagawa Y, Ueshima K, Kimura T
  • Journal Title: PLoS One. Volume: 13 Issue: 11 Pages: e0206945-e0206945
  • DOI: 10.1371/journal.pone.0206945
  • NAID: 120006539573
  • Peer Reviewed / Open Access
• [Journal Article] Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure (2018)
  • Author(s): Takahama Hiroyuki、Takashio Seiji、Nishikimi Toshio、Hayashi Tomohiro、Nagai-Okatani Chiaki、Nakagawa Yasuaki、Amaki Makoto、Ohara Takahiro、Hasegawa Takuya、Sugano Yasuo、Kanzaki Hideaki、Yasuda Satoshi、Kangawa Kenji、Minamino Naoto、Anzai Toshihisa
  • Journal Title: International Journal of Cardiology Volume: 258 Pages: 165-171
  • DOI: 10.1016/j.ijcard.2017.12.047
  • Peer Reviewed
• [Journal Article] Adrenomedullin as a Biomarker (2018)
  • Author(s): Nishikimi T, Nakagawa Y
  • Journal Title: Heart Fail Clin Volume: 14 Issue: 1 Pages: 49-55
  • DOI: 10.1016/j.hfc.2017.08.006
  • Peer Reviewed
• [Journal Article] Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP:Case report. (2017)
  • Author(s): Nakagawa Y, Nishikimi T, Sakai H, Ohno S, Kinoshita H, Inazumi H, Moriuchi K, Kuwahara K, Horie M, Kimura T.
  • Journal Title: Clinical Biochemistry Volume: 52 Pages: 148-152
  • DOI: 10.1016/j.clinbiochem.2017.10.019
  • Peer Reviewed
• [Journal Article] MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts. (2017)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
  • Journal Title: J Am Heart Assoc. Volume: 6 Issue: 2
  • DOI: 10.1161/jaha.116.003601
  • NAID: 120007100125
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity. (2017)
  • Author(s): Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
  • Journal Title: Hypertension. Volume: 69 Issue: 2 Pages: 286-296
  • DOI: 10.1161/hypertensionaha.116.08219
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy (2016)
  • Author(s): Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
  • Journal Title: Cardiovascular Research Volume: 109 Issue: 1 Pages: 162-173
  • DOI: 10.1093/cvr/cvv248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Pro-B type natriuretic peptide (BNP) to total BNP ratio is involved in the pathphysiology of acute and chronic heart failure: elucidateon of molecura mechanism. (2018)
  • Author(s): Toshio Nikishikimi, Yasuaki Nakagawa, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriutchi, Hiromu Yanagisawa, Koichiro Kuwahara, Hiroyuki Takahama, Naoto Minamino, Takeshi Kimura
  • Organizer: ISH(Internal Society of Hypertension) 2018 Scientific Meeting.
  • Int'l Joint Research
• [Presentation] Possibility of proBNP measurement as a new methods for evaluating the heart disease (2018)
  • Author(s): Yasuaki Nakagawa
  • Organizer: 第82回 日本循環器学会学術集会
• [Presentation] G蛋白サブユニットGαoのCa2+ handling恒常性および心収縮能維持における意義の解明. (2018)
  • Author(s): 稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、錦見俊雄、呉林なごみ、山田充彦、柏原俊英、中尾一和、木村剛
  • Organizer: 第55回日本臨床分子医学会学術集会
• [Presentation] 心不全モデルマウスにおけるＧ蛋白サブユニットＧαoの発現亢進はCa2+ handlingの異常をきたし心収縮能低下に関与する. (2018)
  • Author(s): 稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、錦見俊雄、呉林なごみ、山田充彦、中尾一和、木村剛.
  • Organizer: 第91回 日本内分泌学会学術集会
• [Presentation] 左心疾患を合併した強皮症関連肺動脈性肺高血圧症の臨床的特徴 (2018)
  • Author(s): 柳澤 洋, 木下 秀之, 吉藤 元, 森内 健史, 稲住 英明, 斎藤 成達, 中川 靖章, 尾野 亘, 桑原 宏一郎, 木村 剛
  • Organizer: 第3回 日本肺高血圧・肺循環学会学術集会
• [Presentation] Increased Gαo expression underlies cardiac dysfunction accompanied with abnormal Ca2+ handling. (2018)
  • Author(s): Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Oya M, Nishikimi T, Kurebayashi N, Yamada M, Nakao K Kimura T.
  • Organizer: 第2回日本循環器学会基礎研究フォーラム
• [Presentation] 肺移植実施施設からみた病診・病病連携の重要性 (2018)
  • Author(s): 木下秀之、柳澤洋、森内健治、稲住英明、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] 肺動脈性肺高血圧症に対する肺移植術における循環器内科の役割 (2018)
  • Author(s): 木下秀之、柳澤洋、森内健治、稲住英明、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] 肺高血圧症に伴う得心不全の診断と治療 (2018)
  • Author(s): 木下秀之、柳澤洋、森内健治、稲住英明、加藤貴雄、中川靖章、桑原宏一郎、陳豊史、伊達洋至、木村剛
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] A case of left heart failure and pulmonary hypertension during treatment of nintedanib for idiopathic pulmonary fibrosiss (2018)
  • Author(s): Munekazu Tanaka, Hideyuki Kinoshita, Takunori Aizawa, Hiromu Yangisawa, Kenji Moriuchi, Hideyuki Inazumi, Takao kato, Naritatsu Saito, Yasuaki Nakagawa, Koh Ono, Koichiro Kuwahara, Takeshi Kimura
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] Clinical features of the Systemic Sclerosis Associated Pulmonar Arterial Hypertension in the Elderly (2018)
  • Author(s): Masaharu Yoshida, Hideyuki Kinoshita, Munekazu Tanaka, Kazuki Kitano, Hiromu Yangisawa, Kenji Moriuchi, Hideyuki Inazumi, Takao kato, Naritatsu Saito, Yasuaki Nakagawa, Koh Ono, Koichiro Kuwahara, Takeshi Kimura
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] ナトリウム利尿ペプチドを知る～BNPの最近の話題を中心に～ (2018)
  • Author(s): 中川靖章
  • Organizer: 第28回臨床内分泌代謝Update
• [Presentation] Adipocyte-derived adrenomedullin suppresses age-and obesity-related increase in blood pressure (2017)
  • Author(s): Kosai Cho, Takeya Minami, Koichiro Kuwahara, Toshio Nishikimi, Hideaki Kinoshita, Kenji Moriuti, Kaoru Koike, Kenji Naoto Minamino, KangawaYasuaki Nakagawa, Hideyuki Kinoshita, Kazuwa Nakao, Takeshi Kimura
  • Organizer: The81st Annual Scientific Meeting of the Japanese Circulation Sciety
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] 僧帽弁逆流の成因解明にストレインエコーが有用であった心サルコイドーシスの一症例 (2017)
  • Author(s): 米田智也、木下秀之、中島康弘、相澤卓範、岡林真梨恵、中川靖章、桑原宏一郎、木村剛
  • Organizer: The81st Annual Scientific Meeting of the Japanese Circulation Sciety
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] Prediction of poor otcome after PAH targeted therapy in pulmonary arterial hypertension patients with lung disease (2017)
  • Author(s): Hideyuki Kinoshita, Takanari Fujita, HiromuYanagisawa, Kenji Moriuchi, Hideaki Inazumi, Narituatsu Saitoh, Yasuaki Nakagawa, Koichiro Kuwahara, Koh Ono, Takeshi Kimura
  • Organizer: The81st Annual Scientific Meeting of the Japanese Circulation Sciety
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] O-linked oligosaccharide atachment underestimates N-terminal proBNP(NT-proBNP) levels in heart failure (HF) and chronic renal failure (CRF) on hemodyalysis (HD) (2017)
  • Author(s): Toshio Nishikimi, Yasuaki Nakagawa, Koichiro Kuwahara, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Kazuwa Nakao, Takeshi Kimura
  • Organizer: The81st Annual Scientific Meeting of the Japanese Circulation Sciety
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] BNPを識る、そして病態を読む (2017)
  • Author(s): 中川靖章
  • Organizer: The81st Annual Scientific Meeting of the Japanese Circulation Sciety
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] 基礎から考えるBNP検査の臨床応用 (2017)
  • Author(s): 中川靖章
  • Organizer: STROKE2017
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] O-linked oligosaccharaide attachment underestimates N-treminal proBNP-76(NT-proBNP) levels in heart failure(HF) and chronic renal failure (CRF) on hemodialysis (HD) (2017)
  • Author(s): Nishikimi T, Nakagawa Y, Kinoshita H, Moriuchi K, Inazumi H, Kuwahara K, Nakao K, Kimura T.
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] Adipocyte-derived adrenomedullin suppresses age-and obesity-related increase in blood pressure (2017)
  • Author(s): Cho Kozai, Takeya Minami, Toshio Nishikimi, Yasuaki Nakagawa, Kazuwa Nakao, Koichiro Kuwahara, Kaoru Koike, Takeshi Kimura
  • Organizer: ESC Congress 2017
  • Int'l Joint Research
• [Presentation] Impact of continuous reduction in B-type natriuretic peptide bioactivity during hospitalization in patients with advanced heart failure (2017)
  • Author(s): Takahama H, Takashio S, Hayashi T, Okatani-Nagai C, Nishikimi T, Nakagawa Y, Amaki M, Ohara T, Hasegawa T, Sugano Y, Kanzaki H, Yaduda S, Kangawa K, Minamino N, Anzai T
  • Organizer: AHA Scientific Session 2017
  • Int'l Joint Research
• [Presentation] Molar ratio of N-terminal fragment of pro-B-type natriuretic peptide(BNP) to proBNP predicts occurrence of acute kiney injury in patients with acute heart failure (2017)
  • Author(s): Takahama H, Takashio S, Hayashi T, Nishikimi T, Nakagawa Y, Amaki M, Hasegawa T, Sugano Y, Kanzaki H, Yaduda S, Kangawa K, Minamino N, Anzai T.
  • Organizer: AHA Scientific Session 2017
  • Int'l Joint Research
• [Presentation] 脂肪由来のアドレノメデュリンは加齢および肥満に伴う血圧上昇を抑制する (2017)
  • Author(s): 趙晃済、桑原宏一郎、南丈也、錦見俊雄、南野直人、中川靖章、木下秀之、稲住英明、森内健史、寒川賢治、中尾一和、木村剛
  • Organizer: 第５４回日本臨床分子医学会学術集会
• [Presentation] 心臓サルコイドーシスにおける診断と免疫抑制療法 (2017)
  • Author(s): 柳澤洋、加藤 貴雄, 木下 秀之, 中川 靖章, 猪子 森明, 木村 剛
  • Organizer: 第3回 日本心筋症研究会
• [Presentation] サルコイドーシスにおける診断モダリティとステロイド治療. (2017)
  • Author(s): 柳澤洋、加藤 貴雄, 木下 秀之, 中川 靖章, 猪子 森明, 木村 剛
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] 当院における左心疾患を合併した強皮症関連肺動脈性廃屋血圧症の臨床的特徴 (2017)
  • Author(s): 柳澤洋、木下秀之、北野一樹、田中宗和、今田一彰、吉田雅晴、辰島正二郎、森内健史、稲住英明、齋藤成達、中川靖章、尾野亘、木村剛
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] 呼吸器疾患を合併した肺動脈性肺高血圧症患者に対するイロプロスト吸入薬の急性効果の検討 (2017)
  • Author(s): 田中宗和、木下秀之、柳澤洋、今田一彰、吉田雅晴、森内健史、齋藤成達、中川靖章、尾野亘、木村剛
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] A case of Macro-pro-B-Type Natriuretic Peptide (proBNP) (2017)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Hiroshi Sakai, Seiko Ohno, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Koichiro Kuwahara, Minoru Horie, Takeshi kimura
  • Organizer: 第21回日本心不全学会学術集会
• [Presentation] マクロproBNP血症の一例 (2017)
  • Author(s): 中川靖章、錦見俊雄、酒井宏、大野聖子、木下秀之、稲住英明、森内健史、柳澤洋、桑原宏一郎、堀江稔、木村剛
  • Organizer: 第21回心血管内分泌代謝学会(CVMW2017)
• [Presentation] アドレノメデュリンは加齢や肥満に伴う高血圧を抑制する (2017)
  • Author(s): 趙晃済、桑原宏一郎、錦見俊雄、中川靖章、木下秀之、南丈也、稲住英明、森内健史、大矢未来、南野直人、木村剛、寒川賢治、中尾一和
  • Organizer: 脳心血管抗加齢研究会2017
• [Presentation] Possibility of proBNP measurement as a new method for evaluating the heart disease (2017)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Hideyuki, Kinoshita, Hideaki Inazumi, Kenji Moriuchi, HIromu Yanagisawa, Naoto Minamino, kazuwa Nakao, Koichiro Kuwahara, Takeshi Kimura
  • Organizer: 第82日本循環器学科学術集会
• [Presentation] 病的心筋におけるmiR30-GALNT経路による糖鎖修飾を介したproBNP分泌制御 (2016)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
  • Organizer: 第20回日本心血管内分泌代謝学会総会(CVMW2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-12-16
• [Presentation] Secretion of proBNP is regulated by MiR30-GALNTs axis dependent O-linked glycosylation in the pathological myocardium. (2016)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Takao Kato, Naoto Minamino, Kazuwa Nakao, Takeshi Kimura
  • Organizer: AHA Scientific Session 2016
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Endogenous plasma NT-BNP is glycosylated and undetectable with the current NT-BNP assay system (2016)
  • Author(s): Toshio Nishikimi, Yasuaki Nakagawa, Koichiro Kuwahara, Hideyuki Kinoshita, Chinatsu Yamada, Takeshi Kimura, Kazuwa Nakao
  • Organizer: Hypertension Seoul 2016, The 26th Scientific meeting of the International Society of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-24
  • Int'l Joint Research
• [Presentation] MiR30-GALNT1/2 axis-mediatede glycosylation regulates the increase in inactive human pro-BNP secretion from failing heart. (2016)
  • Author(s): Koichiro Kuwahara, Yasuaki Nakagawa, Toshio Nishikimi, Hideyuki Kinoshita, Hiroyuki Okamoto, Takao Kato, Kenji Kangawa, Naoto Minamino, Kazuwa Nakao, Takeshi Kimura
  • Organizer: Hypertension Seoul 2016, The 26th Scientific meeting of the International Society of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-24
  • Int'l Joint Research
• [Presentation] 病的心筋からの脳性ナトリウム利尿ペプチド前駆体proBNP分泌はmiR-30-GALNT経路により制御されている (2016)
  • Author(s): 中川靖章、桑原宏一郎、錦見俊雄、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
  • Organizer: Molecular Cardiovascular Conference II 2016
  • Place of Presentation: 東京
  • Year and Date: 2016-09-03
• [Presentation] Unprocessed proBNP secretion is regulated by MiR30-GALNTs axis dependent O-glycosylation in the pathological myocardium.. (2016)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Hideyuki Kinoshita, Chinatsu Yamada, Hideaki Inazumi, Kazuwa Nakao, Takeshi Kimura
  • Organizer: AHA BCVS2016
  • Place of Presentation: Phoenix, Arizona, USA
  • Year and Date: 2016-07-18
  • Int'l Joint Research
• [Presentation] miR30-GALNT経路によるO型糖鎖修飾調節を介した病的心からのproBNP分泌亢進機序 (2016)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、稲住英明、森内健史、上嶋健治、南野直人、中尾一和、木村剛
  • Organizer: 第２回 国際心血管薬物療法学会日本部会(J-ICPS)
  • Place of Presentation: 徳島
  • Year and Date: 2016-06-25
• [Presentation] MiR30-GALNT1/2 axis-mediated glycosylation at threonine 48 and 71 plays an essential role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing hearts (2016)
  • Author(s): Kuwahara K, Nakagawa Y, Nishikimi T, Kangawa K, Minamino N, Nakao K, Kimura T.
  • Organizer: Heart Failure 2016
  • Place of Presentation: Florence, Italy
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] デュアルインピーダンス法により計測された内臓脂肪面積と自宅血圧の日間変動指標との関連の検討 (2016)
  • Author(s): 桒原純子，桑原宏一郎，堀井和子，桒原佳宏，保野慎治，保野明子，藤永有里子，中川靖章，木下秀之，山田千夏，横井秀基，曽根正勝，上嶋健治，中尾一和，木村剛
  • Organizer: 第5回 日本高血圧学会 臨床高血圧フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2016-05-14
• [Presentation] O型糖転移酵素GALNTのBNPプロセシング調節への関与 (2016)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、木下秀之、山田千夏、稲住英明、南野直人、中尾一和、木村剛
  • Organizer: 第89回 日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2016-04-21
• [Presentation] miR30-GALNT経路によるO型糖鎖修飾を介したBNPプロセシング調節が病的心筋からのproBNP分泌亢進に寄与する (2016)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、山田千夏、稲住英明、上嶋健治、南野直人、中尾一和、木村剛
  • Organizer: 第53回 日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-15
• [Presentation] MiR30-GALNTs axis-mediated O-glycosylation plays an important role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing heart (2016)
  • Author(s): Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Kazuwa Nakao and Takeshi Kimura
  • Organizer: Keystone symposia
  • Place of Presentation: Snowbird, Utah, ISA
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] miR-30-GALNT1,2経路による糖鎖修飾調節が病的心筋からのproBNP分泌に関与する (2016)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、木下秀之、稲住英明、森内健史、南野直人、中尾一和、木村剛
  • Organizer: 第26回 日本循環薬理学会
  • Place of Presentation: 松本
• [Presentation] Ｇ蛋白サブユニットＧαoの発現亢進が拡張型心筋症モデルマウスにおける心機能低下に関与する (2016)
  • Author(s): 稲住英明、桑原宏一郎、桒原佳宏、中川靖章、木下秀之、森内健史、錦見俊雄、呉林なごみ、柏原俊英、山田充彦、中尾一和、木村剛
  • Organizer: 第26回 日本循環薬理学会
  • Place of Presentation: 松本
• [Book] Endocrinology of the Heart in Health and Disease. Chapter 2 Adrenomedullin. (2017)
  • Author(s): T. Nishikimi, K. Kuwahara, Y. Nakagawa, K Kangawa, and K. Nakao
  • Total Pages: 18
  • Publisher: Elsevier Scinence
• [Remarks] 京都大学医学部附属病院 循環器内科 心血管内分泌代謝グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/cat236/
• [Remarks] 京都大学大学院医学研究科循環器内科心血管内分泌代謝グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/cat236/
• [Remarks] 京都大学医学部付属病院循環器内科 心血管内分泌代謝グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/cat236/