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Exploratory research of the role and regulation of alveolar nitric oxide on physical inactivity in COPD

Research Project

Project/Area Number 16K09542
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionYamaguchi University

Principal Investigator

HIRANO Tsunahiko  山口大学, 医学部附属病院, 准教授 (00382333)

Co-Investigator(Kenkyū-buntansha) 松永 和人  山口大学, 大学院医学系研究科, 教授 (20347602)
椎木 健裕  山口大学, 医学部附属病院, 講師 (30610456)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords身体活動性障害 / 窒素化ストレス / COPD / 抹消気道 / 気管支喘息 / 末梢気道
Outline of Final Research Achievements

In obstructive lung disease (OLD),it is suggested that physical activity is correlated with not only intra- pulmonary factors such as airflow limitation, pulmonary hyperinflation and breathless in daily behavior but also extra-pulmonary factors such as vital function and active motivation to exercises. Moreover, we showed that function small airway and air trap detected by CT imaging is related with physical activity. The consequence assumed that quantitative inspiratory-to-expiratory CT imaging can be biomarker to detect physical activity levels. Next we assessed the relationship between airway inflammation and physical activity in asthma. The result was that physical inactivity in asthma might be related to the exercise intolerance by small airway inflammation.

Academic Significance and Societal Importance of the Research Achievements

本研究で使用したシステムは、身体活動性の維持や改善のための的確な治療薬の処方、効果判定や維持量の調節などの閉塞性肺疾患の管理効率の向上に寄与するばかりでなく、閉塞性肺疾患以外の呼吸器疾患の身体活動性障害の制御に応用できる点に学術的意義がある。本研究は 閉塞性肺疾患の日常生活の制限からの開放といった QOL の改善はもとより、全身併存症の悪化や増悪抑制による医療費の削減にも貢献できる点に社会的意義がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (73 results)

All 2018 2017 2016

All Journal Article (20 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (39 results) (of which Int'l Joint Research: 9 results,  Invited: 14 results) Book (14 results)

  • [Journal Article] Deep Sternal Wound Tuberculosis with Hypo-gamma-globulinemia2018

    • Author(s)
      Hamada K, Oishi K, Uehara S, Suetake R, Yamaji Y, Asami-Noyama M, Edakuni N, Hirano T, Sakamoto K, Matsumoto T, Matsunaga K
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 17 Pages: 2563-2566

    • DOI

      10.2169/internalmedicine.0617-17

    • NAID

      130007479994

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-09-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late-onset asthma: current perspectives.2018

    • Author(s)
      Hirano T, Matsunaga K
    • Journal Title

      J Asthma Allergy

      Volume: 11 Pages: 19-27

    • DOI

      10.2147/jaa.s125948

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swyer-James Syndrome2018

    • Author(s)
      Hamada Kazuki、Oishi Keiji、Hirano Tsunahiko、Shiinoki Takehiro、Shibuya Keiko、Matsunaga Kazuto
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 197 Issue: 1 Pages: 130-131

    • DOI

      10.1164/rccm.201708-1691im

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-step algorithm for biological therapy targeted IgE and IL-5 in severe asthma2018

    • Author(s)
      Oishi Keiji、Matsunaga Kazuto
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: 6 Issue: 3 Pages: 374-376

    • DOI

      10.1002/iid3.233

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Obesity and severe asthma in Japan: Similarities and differences with Western countries.2018

    • Author(s)
      Matsunaga K
    • Journal Title

      Respir Investig

      Volume: 56(6) Issue: 6 Pages: 430-431

    • DOI

      10.1016/j.resinv.2018.08.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of 2017 GOLD COPD group A: a multicenter cross-sectional CAP study in Japan2018

    • Author(s)
      Oishi Keiji、Hirano Tsunahiko、Hamada Kazuki、Uehara Sho、Suetake Ryo、Yamaji Yoshikazu、Ito Kosuke、Asami-Noyama Maki、Edakuni Nobutaka、Matsunaga Kazuto
    • Journal Title

      International Journal of Chronic Obstructive Pulmonary Disease

      Volume: Volume 13 Pages: 3901-3907

    • DOI

      10.2147/copd.s181938

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Determinants of Incomplete Asthma Control in Patients with Allergic Rhinitis and Asthma.2017

    • Author(s)
      Oka A, Hirano T, Yamaji Y, Ito K, Oishi K, Edakuni N, Kawano R, Matsunaga K
    • Journal Title

      The Journal of Allergy and Clinical Immunology

      Volume: 5(1) Issue: 1 Pages: 160-164

    • DOI

      10.1016/j.jaip.2016.08.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A trial of oral corticosteroids for persistent systemic and airway inflammation in severe asthma.2017

    • Author(s)
      Oishi K, Hirano T, Suetake R, Ohata S, Yamaji Y, Ito K, Edakuni N, Matsunaga K
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: 5(3) Issue: 3 Pages: 261-264

    • DOI

      10.1002/iid3.166

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exhaled nitric oxide measurements in patients with acute-onset interstitial lung disease.2017

    • Author(s)
      Oishi K, Hirano T, Suetake R, Ohata S, Yamaji Y, Ito K, Edakuni N, Matsunaga K
    • Journal Title

      Journal of Breath Research

      Volume: 11(3) Issue: 3 Pages: 036001-036001

    • DOI

      10.1088/1752-7163/aa6c4b

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of immunoglobulin G4 and free light chain with idiopathic pleural effusion.2017

    • Author(s)
      4.Murata Y, Aoe K, Mimura-Kimura Y, Murakami T, Oishi K, Matsumoto T, Ueoka H, Matsunaga K, Yano M, Mimura Y
    • Journal Title

      Clin Exp Immunol

      Volume: 190(1) Issue: 1 Pages: 133-142

    • DOI

      10.1111/cei.12999

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 吸入ステロイド薬の進歩-治療戦略を中心に. 喘息・COPD吸入治療の新しい展開2017

    • Author(s)
      平野綱彦, 松永和人
    • Journal Title

      医学のあゆみ

      Volume: 261(3) Pages: 234-238

    • Related Report
      2017 Research-status Report
  • [Journal Article] 気道リモデリングと重症化2017

    • Author(s)
      平野綱彦, 松永和人
    • Journal Title

      喘息・アレルギー

      Volume: 30(1) Pages: 40-44

    • Related Report
      2017 Research-status Report
  • [Journal Article] DPIの立場から(吸入療法の第1選択はpMDIか,DPIか).2017

    • Author(s)
      枝國信貴, 松永和人
    • Journal Title

      喘息・アレルギー

      Volume: 30(1) Pages: 101-105

    • Related Report
      2017 Research-status Report
  • [Journal Article] 気道の炎症をめぐって Ⅷ. One airway, one disease.2017

    • Author(s)
      大石景士, 松永和人
    • Journal Title

      アレルギー・免疫

      Volume: 24(4) Pages: 72-80

    • Related Report
      2017 Research-status Report
  • [Journal Article] 肺高血圧症・右心不全に至った症例の管理の注意点2017

    • Author(s)
      國近尚美, 大石景士, 松永和人
    • Journal Title

      Mebio

      Volume: 34(9) Pages: 48-55

    • Related Report
      2017 Research-status Report
  • [Journal Article] 喘息の診療:最新治療.2017

    • Author(s)
      大石景士, 平野綱彦, 松永和人
    • Journal Title

      臨牀と研究

      Volume: 94(11) Pages: 48-55

    • Related Report
      2017 Research-status Report
  • [Journal Article] 肺炎2017

    • Author(s)
      枝國信貴, 松永和人
    • Journal Title

      薬局

      Volume: 68(13) Pages: 45-50

    • Related Report
      2017 Research-status Report
  • [Journal Article] 成人喘息のバイオマーカーとしての呼気NO.2017

    • Author(s)
      村田順之, 松永和人
    • Journal Title

      アレルギーの臨床

      Volume: 68(13) Pages: 17-21

    • Related Report
      2017 Research-status Report
  • [Journal Article] Persistently high exhaled nitric oxide and loss of lung function in controlled asthma2016

    • Author(s)
      Kazuto Matsunaga Tsunahiko Hirano Asako Oka kousuke Ito Nobutaka Edakuni
    • Journal Title

      Allergology International

      Volume: 65 Issue: 3 Pages: 266-271

    • DOI

      10.1016/j.alit.2015.12.006

    • NAID

      130005165877

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in physical activity according to mMRC grade in patients with COPD.2016

    • Author(s)
      Hayata A, Minakata Y, Matsunaga K, Nakanishi M, Yamamoto N
    • Journal Title

      International Journal of COPD

      Volume: 11 Pages: 2203-2208

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Detection of Biomarkers of Steroid Response in COPD(De-Stress Study).2018

    • Author(s)
      Yamaji Y, Oishi K, Uehara S, Hamada K, Suetake R, Ito K, Asami M, Edakuni N, Hirano T, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of Type 2 inflammation in obstructive lung disease.2018

    • Author(s)
      Matsunaga K
    • Organizer
      Vietnam Respiratory Society 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exhaled Nitric Oxide (FeNO) Measurement in the Auxiliary Diagnosis of Late-Onset Asthma.2018

    • Author(s)
      Suetake R, Asami M, Hirano T, Hamada K, Uehara S, Oishi K, Yamaji Y, Edakuni N, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medication Persistence Rates and Factors of Anti-Fibrotic Agents for Idiopathic Pulmonary Fibrosis: A Real-World Observational Study.2018

    • Author(s)
      Oishi K, Hirano T, Hamada K, Uehara S, Suetake R, Yamaji Y, Asami M, Edakuni N, Matsumoto T, Yano M, Matsunaga K
    • Organizer
      American Thoracic Society International Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鼻副鼻腔炎と喘息の関連機序2018

    • Author(s)
      松永和人
    • Organizer
      第36回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 気道炎症の観点からみたOne airway , One disease2018

    • Author(s)
      平野綱彦
    • Organizer
      第36回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 増悪リスクのトータルマネジメント2018

    • Author(s)
      松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 呼気NO測定の意義と解釈 up-to-date2018

    • Author(s)
      松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Multimodal imagingが診断と病態生理の理解に有用と考えられたSwyer-James症候群の31歳女性例2018

    • Author(s)
      濱田和希, 大石景士, 上原翔, 末竹諒, 山路義和, 浅見麻紀, 枝國信貴, 平野綱彦, 椎木健裕, 澁谷景子, 松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 晩期発症喘息の補助診断における呼気NO濃度測定2018

    • Author(s)
      末竹諒, 浅見麻紀, 平野綱彦, 濱田和希, 上原翔, 大石景士, 山路義和, 枝國信貴, 松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] COPDにおける吸入ステロイド薬の反応性を予測するパラメータの探索2018

    • Author(s)
      山路義和, 大石景士, 上原翔, 濱田和希, 末竹諒, 伊藤光佑, 浅見麻紀, 枝國信貴, 平野綱彦, 松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 実臨床における抗線維化薬の治療継続に関する予測因子の検討2018

    • Author(s)
      大石景士, 平野綱彦, 濱田和希, 上原翔, 末竹諒, 山路義和, 浅見麻紀, 枝國信貴, 松本常男, 松永和人
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺癌薬物療法2018~免疫療法と細胞障害性抗癌剤の役割~2018

    • Author(s)
      松永和人
    • Organizer
      第57回日本肺癌学会中国・四国支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] EXHALED NITRIC OXIDE MEASUREMENTS IN PATIENTS WITH ACUTE-ONSET INTERSTITIAL LUNG DISEASE.2017

    • Author(s)
      Oishi K, Hirano T, Suetake R, Ohata S, Yamaji Y, Ito K, Edakuni N, Yano M, Matsunaga K
    • Organizer
      ERS INTERNATIONAL CONGRESS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] COPD:増悪の抑制に向けた新たな展開.2017

    • Author(s)
      松永和人
    • Organizer
      第92回日本結核病学会総会, 東京都千代田区(東京国際フォーラム)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 呼気NO濃度測定の意義と評価2017

    • Author(s)
      松永和人
    • Organizer
      第57回日本呼吸器学会学術講演会教育講演, 東京都千代田区(東京国際フォーラム)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] COPDと循環器疾患2017

    • Author(s)
      松永和人
    • Organizer
      第57回日本呼吸器学会学術講演会, 東京都千代田区(東京国際フォーラム)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 非専門医のための喘息治療の基本戦略2017

    • Author(s)
      松永和人
    • Organizer
      第79回耳鼻咽喉科臨床学会, 下関市(海峡メッセ下関)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 喘息管理における呼気NOモニタリングの展望2017

    • Author(s)
      松永和人
    • Organizer
      第78回日本呼吸器学会・日本結核病学会 九州支部春季学術講演会, 福岡市(福岡国際医療福祉学院)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] COPDの診断と治療~最近の進歩~2017

    • Author(s)
      松永和人
    • Organizer
      第116日本内科学会中国地方会第56回中国支部主催生涯教育講演会, 宇部市(山口大学医学部)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 高齢者喘息UPDATE2017

    • Author(s)
      松永和人
    • Organizer
      第79回日本呼吸器学会・日本結核病学会・日本サルコイドーシス/肉芽腫性疾患学会九州支部秋季学術講演会, 別府市
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Streptococcus agalactiaeによる肺化膿症に化膿性脊椎炎が合併した1例.2017

    • Author(s)
      大畑秀一郎, 山路義和, 末竹諒, 伊藤光佑, 枝國信貴, 平野綱彦, 松永和人, 大石景士
    • Organizer
      第116日本内科学会中国地方会第56回中国支部主催生涯教育講演会, 宇部市(山口大学医学部)
    • Related Report
      2017 Research-status Report
  • [Presentation] 特発性肺線維症に対する抗線維化薬の大規模臨床試験と実臨床離の検討.2017

    • Author(s)
      大石景士, 矢野雅文, 平野綱彦, 松永和人, 松本常男
    • Organizer
      第116日本内科学会中国地方会第56回中国支部主催生涯教育講演会, 宇部市(山口大学医学部)
    • Related Report
      2017 Research-status Report
  • [Presentation] 呼気NO濃度の経時的な測定が診断・病勢評価に有用であった急性好酸球性肺炎の19歳男性例2017

    • Author(s)
      末竹諒, 大畑秀一郎, 山路義和, 枝國信貴, 平野綱彦, 松永和人, 大石景士, 久保誠, 石井文彩, 池田栄二
    • Organizer
      第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
    • Related Report
      2017 Research-status Report
  • [Presentation] Dual-energy perfusion CTが診断に有用と考えられたSwyer-James症候群の31歳女性例2017

    • Author(s)
      濱田和希, 大石景士, 末竹諒, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 椎木健裕, 澁谷景子, 松永和人
    • Organizer
      第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
    • Related Report
      2017 Research-status Report
  • [Presentation] 総IgE上昇を認めなかったスエヒロタケ(Schizophyllumcommune)によるアレルギー性気管支肺真菌症2017

    • Author(s)
      伊達直人, 大石景士, 末竹諒, 濱田和希, 上原翔, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 松永和人
    • Organizer
      第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
    • Related Report
      2017 Research-status Report
  • [Presentation] 腫瘍随伴性天疱瘡に伴う閉塞性細気管支炎様肺病変をきたした63歳女性剖検例2017

    • Author(s)
      吉野佑, 大石景士, 末竹諒, 大畑秀一郎, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 伊藤浩史, 松永和人
    • Organizer
      第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
    • Related Report
      2017 Research-status Report
  • [Presentation] 洗浄後ファイバースコープの微生物汚染の実態と対策2017

    • Author(s)
      枝國信貴, 松永和人
    • Organizer
      第87回日本感染症学会西日本地方会学術集会, 長崎市(長崎ブリックホール)
    • Related Report
      2017 Research-status Report
  • [Presentation] 非結核性抗酸菌の吸入によって発症した過敏性肺炎疑いの1例2017

    • Author(s)
      岩本夏彦, 上原翔, 山路義和, 濱田和希, 末竹諒, 大石景士, 浅見麻紀, 枝國信貴, 平野綱彦, 松永和人
    • Organizer
      第58回日本呼吸器学会中国・四国地方会(広島大学東千田未来創生センター)
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗Th/To抗体( 抗7-2RNA ) が陽性となった強皮症合併間質性肺炎の1例2017

    • Author(s)
      上原翔, 山路義和, 濱田和希, 末竹諒, 大石景士, 浅見麻紀, 枝國信貴, 平野綱彦, 松永和人
    • Organizer
      第58回日本呼吸器学会中国・四国地方会(広島大学東千田未来創生センター
    • Related Report
      2017 Research-status Report
  • [Presentation] FeNOと抗炎症治療2016

    • Author(s)
      松永和人
    • Organizer
      第26回国際喘息学会日本・北アジア部会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Survival from acute exacerbation of idiopathic pulmonary fibrosis with or without direct hemoperfusion with polymyxin B-immobilized fiber column:A retrospective analysis.2016

    • Author(s)
      Keiji Oishi, Keisuke Aoe, Yusuke Mimura, Yoriyuki Murata, Kenji Sakamoto, Wataru Koutoku, Tsuneo Matsumoto, Hiroshi Ueoka, Kazuto Mastunaga, Masafumi Yano
    • Organizer
      ERS INTERNATIONAL CONGRESS 2016
    • Place of Presentation
      LONDON(United Kingdom)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cross-talk between TNF-LIGHT and nitrosative stress in the airway remodeling of asthma.2016

    • Author(s)
      Tsunahiko Hirano, Kosuke Ito, Nobutaka Edakuni, Kazuto Matsunaga
    • Organizer
      ERS INTERNATIONAL CONGRESS 2016
    • Place of Presentation
      LONDON(United Kingdom)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] One airway one diseaseと炎症性メディエーター:脂質メディエーターを中心に2016

    • Author(s)
      松永和人
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Enhancement to asthma management efficiency by FeNO measurement.2016

    • Author(s)
      Kazuto Matsunaga
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      SENDAI INTERNATIONAL CENTER(宮城県仙台市)
    • Year and Date
      2016-05-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 呼気NOによる喘息モニタリングの意義2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 喘息気道のリモデリング進展は防止できるか?2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 病像・病態からみた高齢者喘息2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] COPDでの臨床的知見の提示:呼吸機能低下と喫煙や急性増悪などの呼吸機能への影響2016

    • Author(s)
      平野綱彦
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 今日の治療指針 2018年版[デスク判]2018

    • Author(s)
      福井次矢, 松永和人
    • Total Pages
      2066
    • Publisher
      医学書院
    • ISBN
      9784260032339
    • Related Report
      2018 Annual Research Report
  • [Book] 第23回3学会合同呼吸療法認定士認定講習会テキスト2018

    • Author(s)
      遠藤一彦, 黒澤一, 桑平一郎, 滝澤始, 松永和人, 四元秀毅
    • Total Pages
      540
    • Publisher
      3学会合同呼吸療法認定士認定委員会
    • Related Report
      2018 Annual Research Report
  • [Book] 診断と治療のABC2018

    • Author(s)
      平田一人, 山路義和, 松永和人
    • Total Pages
      238
    • Publisher
      最新医学社
    • Related Report
      2018 Annual Research Report
  • [Book] 呼吸器内科Vol.34, Suppl.12018

    • Author(s)
      平野綱彦, 松永和人
    • Total Pages
      523
    • Publisher
      科学評論社
    • Related Report
      2018 Annual Research Report
  • [Book] 呼吸器内科Vol.34, No.12018

    • Author(s)
      村田順之, 松永和人
    • Total Pages
      102
    • Publisher
      科学評論社
    • Related Report
      2018 Annual Research Report
  • [Book] 日本内科学会雑誌第107巻, 第10号2018

    • Author(s)
      平野綱彦, 松永和人
    • Total Pages
      2217
    • Publisher
      一般社団法人日本内科学会
    • Related Report
      2018 Annual Research Report
  • [Book] COPD(慢性閉塞性肺疾患). 今日の診療のために ガイドライン外来診療2017

    • Author(s)
      大石景士, 松永和人
    • Total Pages
      650
    • Publisher
      日経メディカル開発
    • ISBN
      9784931400818
    • Related Report
      2017 Research-status Report
  • [Book] グッドパスチャー症候群. 今日の治療指針 私はこう治療している,2017

    • Author(s)
      松永和人
    • Total Pages
      1999
    • Publisher
      医学書院
    • ISBN
      9784260032346
    • Related Report
      2017 Research-status Report
  • [Book] 喘息・COPD・ACOSの鑑別はどう進める?. もう悩まない!喘息・COPD・ACOSの外来診療2016

    • Author(s)
      松永和人, 他
    • Total Pages
      205
    • Publisher
      羊土社
    • Related Report
      2016 Research-status Report
  • [Book] COPD・ACOS関連疾患. もう悩まない!喘息・COPD・ACOSの外来診療2016

    • Author(s)
      松永和人, 他
    • Total Pages
      205
    • Publisher
      羊土社
    • Related Report
      2016 Research-status Report
  • [Book] COPD(慢性閉塞性肺疾患). 今日の診療のためにガイドライン外来診療20162016

    • Author(s)
      大石景士, 松永和人
    • Total Pages
      605
    • Publisher
      日経メディカル開発
    • Related Report
      2016 Research-status Report
  • [Book] 喘息:呼気NO測定の活用法. 内科INTERNAL 122016

    • Author(s)
      大石景士, 松永和人
    • Total Pages
      1181
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report
  • [Book] 呼気検査. アレルギーの疾患のすべて2016

    • Author(s)
      松永和人, 他
    • Total Pages
      366
    • Publisher
      日本医師会雑誌
    • Related Report
      2016 Research-status Report
  • [Book] COPD治療におけるテオフィリン製剤の意義は?. EBM呼吸器疾患の治療〈2016-2017〉2016

    • Author(s)
      平野綱彦, 他
    • Total Pages
      495
    • Publisher
      中外医学社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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