Exploratory research of the role and regulation of alveolar nitric oxide on physical inactivity in COPD
Project/Area Number |
16K09542
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Yamaguchi University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松永 和人 山口大学, 大学院医学系研究科, 教授 (20347602)
椎木 健裕 山口大学, 医学部附属病院, 講師 (30610456)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 身体活動性障害 / 窒素化ストレス / COPD / 抹消気道 / 気管支喘息 / 末梢気道 |
Outline of Final Research Achievements |
In obstructive lung disease (OLD),it is suggested that physical activity is correlated with not only intra- pulmonary factors such as airflow limitation, pulmonary hyperinflation and breathless in daily behavior but also extra-pulmonary factors such as vital function and active motivation to exercises. Moreover, we showed that function small airway and air trap detected by CT imaging is related with physical activity. The consequence assumed that quantitative inspiratory-to-expiratory CT imaging can be biomarker to detect physical activity levels. Next we assessed the relationship between airway inflammation and physical activity in asthma. The result was that physical inactivity in asthma might be related to the exercise intolerance by small airway inflammation.
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Academic Significance and Societal Importance of the Research Achievements |
本研究で使用したシステムは、身体活動性の維持や改善のための的確な治療薬の処方、効果判定や維持量の調節などの閉塞性肺疾患の管理効率の向上に寄与するばかりでなく、閉塞性肺疾患以外の呼吸器疾患の身体活動性障害の制御に応用できる点に学術的意義がある。本研究は 閉塞性肺疾患の日常生活の制限からの開放といった QOL の改善はもとより、全身併存症の悪化や増悪抑制による医療費の削減にも貢献できる点に社会的意義がある。
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Deep Sternal Wound Tuberculosis with Hypo-gamma-globulinemia2018
Author(s)
Hamada K, Oishi K, Uehara S, Suetake R, Yamaji Y, Asami-Noyama M, Edakuni N, Hirano T, Sakamoto K, Matsumoto T, Matsunaga K
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Journal Title
Internal Medicine
Volume: 57
Issue: 17
Pages: 2563-2566
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-09-01
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Peer Reviewed
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[Presentation] Medication Persistence Rates and Factors of Anti-Fibrotic Agents for Idiopathic Pulmonary Fibrosis: A Real-World Observational Study.2018
Author(s)
Oishi K, Hirano T, Hamada K, Uehara S, Suetake R, Yamaji Y, Asami M, Edakuni N, Matsumoto T, Yano M, Matsunaga K
Organizer
American Thoracic Society International Conference 2018
Related Report
Int'l Joint Research
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[Presentation] Multimodal imagingが診断と病態生理の理解に有用と考えられたSwyer-James症候群の31歳女性例2018
Author(s)
濱田和希, 大石景士, 上原翔, 末竹諒, 山路義和, 浅見麻紀, 枝國信貴, 平野綱彦, 椎木健裕, 澁谷景子, 松永和人
Organizer
第58回日本呼吸器学会学術講演会
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[Presentation] 呼気NO濃度の経時的な測定が診断・病勢評価に有用であった急性好酸球性肺炎の19歳男性例2017
Author(s)
末竹諒, 大畑秀一郎, 山路義和, 枝國信貴, 平野綱彦, 松永和人, 大石景士, 久保誠, 石井文彩, 池田栄二
Organizer
第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
Related Report
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[Presentation] Dual-energy perfusion CTが診断に有用と考えられたSwyer-James症候群の31歳女性例2017
Author(s)
濱田和希, 大石景士, 末竹諒, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 椎木健裕, 澁谷景子, 松永和人
Organizer
第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
Related Report
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[Presentation] 総IgE上昇を認めなかったスエヒロタケ(Schizophyllumcommune)によるアレルギー性気管支肺真菌症2017
Author(s)
伊達直人, 大石景士, 末竹諒, 濱田和希, 上原翔, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 松永和人
Organizer
第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
Related Report
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[Presentation] 腫瘍随伴性天疱瘡に伴う閉塞性細気管支炎様肺病変をきたした63歳女性剖検例2017
Author(s)
吉野佑, 大石景士, 末竹諒, 大畑秀一郎, 山路義和, 野山麻紀, 枝國信貴, 平野綱彦, 伊藤浩史, 松永和人
Organizer
第57回日本呼吸器学会中国・四国地方会, 高知市(文化プラザかるぽーと)
Related Report
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