| Project/Area Number |
16K09572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
Matsui Hiroki 群馬大学, 大学院保健学研究科, 講師 (20431710)
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| Co-Investigator(Kenkyū-buntansha) |
横山 知行 群馬大学, 大学院保健学研究科, 教授 (70312890)
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| Research Collaborator |
KURABAYASHI MASAHIKO
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂肪酸組成 / 肺気腫 / 喫煙 / 触媒酵素 / 肺線維症 / Elovl6 / 飽和脂肪酸 / 不飽和脂肪酸 / 脂肪酸分画 / 酵素 / 脂肪酸 / 呼吸器疾患 / 肺サーファクタント |
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| Outline of Final Research Achievements |
Pulmonary surfactant is essential for the maintenance of proper pulmonary function. It consists of approximately 90 percent of lipids and 10 percent of proteins. However, little is known about the change of lipid composition in the pathogenesis of lung diseases. Then, we focused on the elongase of long chain fatty acids 6, Elovl6, which catalyzes the elongation of long-chain fatty acid. Our data showed deterioration of cigarette smoke-induced pulmonary emphysema in Elovl6-deficient mice. These mice also showed decrease in expression of catalytic enzyme that regulate lipid composition of pulmonary surfactant, or decrease in expression of protein that regulate development of pulmonary emphysema. Our results suggest that deranged fatty acid composition modulated by Elovl6 has a key role in the development of pulmonary emphysema.
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| Academic Significance and Societal Importance of the Research Achievements |
肺サーファクタントの合成・機能異常により、肺気腫を呈することが報告されているが、これまで肺サーファクタントタンパクを中心に研究が進んでおり、脂質の病態意義に関しては明らかにされてこなかった。我々の結果から、喫煙刺激によってElovl6の発現や活性が変化し、その変化に伴って肺局所の脂肪酸組成が変化し、肺気腫の病態に影響することから、新たな病態機序の解明や創薬、治療応用へつながることが期待される。
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