| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Intestinal epithelial cell-specific mineralocorticoid receptor (MR) knockout mice were generated through crossbreeding of MR-flox mice with villin-Cre mice. This model exhibited high fecal excretion of sodium and resistance to DOCA/salt-induced blood pressure elevation, in which the regulation of epithelial Na channel (ENaC) expression was mainly involved. It was also demonstrated that this model exhibited severe dehydration probably due to fecal sodium loss, which lead to significantly lower blood pressure compared with control mice. These findings were published in J Am Heart assoc.
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