PET imaging for oxidative stress in patients with Alzheimer's disease
| Project/Area Number |
16K09712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | University of Fukui |
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Principal Investigator |
Ikawa Masamichi 福井大学, 学術研究院医学系部門, 講師 (60444212)
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| Co-Investigator(Kenkyū-buntansha) |
岡沢 秀彦 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
米田 誠 福井県立大学, 看護福祉学部, 教授 (70270551)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルツハイマー病 / 酸化ストレス / PETイメージング / 認知症 / 脳神経疾患 / 痴呆 / 放射線 |
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| Outline of Final Research Achievements |
Oxidative stress is assumed to be the pathogenic mechanisms underlying Alzheimer's disease (AD). In this study, we applied [Cu-64]ATSM PET/MRI to image cerebral oxidative stress in living patients with AD. PET imaging successfully demonstrated the increased uptake in brain patients with AD. The uptake correlated with disease severity, indicating that oxidative stress is associated with the neurodegenerative process in AD. [Cu-64]ATSM PET/MRI imaging for oxidative stress has improved our insights into the pathological mechanisms of neurodegenerative diseases including AD and may be a promising tool for monitoring further antioxidant therapies.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，これまで基礎研究やモデル動物のみで示されていた，アルツハイマー病（AD）の病態における酸化ストレス増強を，実際の患者生体で明らかにすることができた点に大きな学術的意義がある．本研究の成果によって，[Cu-64]ATSM PET/MRIの酸化ストレスイメージングとしての有用性が示され，さらに酸化ストレスの抑制がADに対して有効である可能性が示唆された．ADに対する予防・予測および創薬につながる成果であると考えられる．
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Arterial spin labeling MR imaging for the clinical detection of cerebellar hypoperfusion in patients with spinocerebellar degeneration.2018
Author(s)
Ikawa M, Kimura, H, Kitazaki Y, Sugimoto K, Matsunaga A, Hayashi K, Yamamura O, Tsujikawa T, Hamano T, Yoneda M, Okazawa H, Nakamoto Y.
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Journal Title
J Neurol Sci
Volume: 394
Pages: 58-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison of four 11C-labeled PET ligands to quantify translocator protein 18?kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176?based on recent publications that measured specific-to-non-displaceable ratios2017
Author(s)
Fujita M, Kobayashi M, Ikawa M, Gunn RN,, Rabiner EA, Owen DR, Zoghbi SS, Haskali MB, Telu S, Pike VW, Innis RB
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Journal Title
EJNMMI Research
Volume: 7
Issue: 1
Pages: 84-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain2017
Author(s)
Ikawa M, Lohith TG, Shrestha S, Telu S, Zoghbi SS, Castellano S, Taliani S, Da Settimo F, Fujita M, Pike VW, Innis RB; Biomarkers Consortium Radioligand Project Team
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Journal Title
J Nucl Med
Volume: 58
Issue: 2
Pages: 320-325
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Book] 脳内環境辞典2017
Author(s)
米田 誠, 井川 正道, 岡沢 秀彦
Total Pages
2
Publisher
メディカルドゥ
Related Report
